SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.97A 1ax9A-3nwoA:
13.8		 1ax9A-3nwoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.60A 1dx6A-3nwoA:
13.8		 1dx6A-3nwoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 HIS A 283
ASP A 199
ASP A 202
PRO A 197
 None
 1.28A 1ilqA-3nwoA:
undetectable
1ilqC-3nwoA:
undetectable		 1ilqA-3nwoA:
10.67
1ilqC-3nwoA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.74A 1maaD-3nwoA:
14.0		 1maaD-3nwoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 271
GLN A 296
HIS A 108
SER A 132
 None
 1.22A 1nx9A-3nwoA:
13.3		 1nx9A-3nwoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 271
GLN A 296
HIS A 108
SER A 132
 None
 1.20A 1nx9B-3nwoA:
15.2		 1nx9B-3nwoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 271
GLN A 296
HIS A 108
SER A 132
 None
 1.21A 1nx9C-3nwoA:
13.2		 1nx9C-3nwoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 271
GLN A 296
HIS A 108
SER A 132
 None
 1.20A 1nx9D-3nwoA:
15.2		 1nx9D-3nwoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 274
ALA A 249
HIS A 280
 None
None
EDO  A 312 (-4.7A)
 0.76A 1q23C-3nwoA:
undetectable		 1q23C-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 274
ALA A 249
HIS A 280
 None
None
EDO  A 312 (-4.7A)
 0.70A 1q23H-3nwoA:
undetectable		 1q23H-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 274
ALA A 249
HIS A 280
 None
None
EDO  A 312 (-4.7A)
 0.75A 1q23G-3nwoA:
undetectable		 1q23G-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.64A 1qtiA-3nwoA:
13.8		 1qtiA-3nwoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 GLY A 111
GLY A 119
MET A 117
LEU A 118
SER A 138
 None
None
GOL  A 311 ( 3.8A)
None
None
 1.30A 1qzzA-3nwoA:
undetectable		 1qzzA-3nwoA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.58A 1w6rA-3nwoA:
14.0		 1w6rA-3nwoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.60A 1w76B-3nwoA:
13.4		 1w76B-3nwoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 1.02A 2ackA-3nwoA:
2.4		 2ackA-3nwoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 116
GLY A 115
GLY A  41
SER A 138
 None
None
EDO  A 312 ( 4.5A)
None
 0.52A 3d41A-3nwoA:
undetectable		 3d41A-3nwoA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A  48
ALA A 209
GLY A  44
THR A  19
 None
 0.92A 3dl9A-3nwoA:
undetectable		 3dl9A-3nwoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 229
TRP A 114
GLY A  41
PRO A  43
 GOL  A 311 (-4.4A)
None
EDO  A 312 ( 4.5A)
GOL  A 311 (-4.8A)
 0.89A 3ny4A-3nwoA:
undetectable		 3ny4A-3nwoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  95
CYH A  99
HIS A  96
 None
 1.15A 3u9fF-3nwoA:
undetectable		 3u9fF-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  95
CYH A  99
HIS A  96
 None
 1.21A 3u9fG-3nwoA:
undetectable		 3u9fG-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A  95
CYH A  99
HIS A  96
 None
 1.20A 3u9fL-3nwoA:
undetectable		 3u9fL-3nwoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.60A 4ey6A-3nwoA:
14.2		 4ey6A-3nwoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  41
GLY A  42
TYR A 214
SER A 113
HIS A 280
 EDO  A 312 ( 4.5A)
EDO  A 312 (-3.7A)
None
GOL  A 311 (-2.8A)
EDO  A 312 (-4.7A)
 0.60A 4ey6B-3nwoA:
14.0		 4ey6B-3nwoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  73
GLY A 129
LEU A  39
HIS A  40
PHE A  91
 None
 1.13A 5eqbA-3nwoA:
undetectable		 5eqbA-3nwoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  39
GLY A  41
GLY A  44
ILE A 122
GLY A 115
 None
EDO  A 312 ( 4.5A)
None
None
None
 1.02A 5wyqA-3nwoA:
undetectable		 5wyqA-3nwoA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3nwo PROLINE
IMINOPEPTIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 275
PRO A 276
GLY A 277
THR A 278
 None
 0.63A 5x24A-3nwoA:
undetectable		 5x24A-3nwoA:
21.37