SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		4 / 6 LEU A 156
VAL A 210
VAL A 218
GLN A 221
 None
 0.92A 1e7aB-3nwpA:
undetectable		 1e7aB-3nwpA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		4 / 6 HIS A 211
ASP A 209
ASP A 208
PRO A 214
 None
 1.46A 1ilqA-3nwpA:
undetectable
1ilqC-3nwpA:
undetectable		 1ilqA-3nwpA:
13.76
1ilqC-3nwpA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.76A 1jffB-3nwpA:
undetectable		 1jffB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 7 TRP A  74
GLU A  72
ALA A 115
ASN A 106
ALA A 118
 None
 1.22A 2ejfA-3nwpA:
undetectable		 2ejfA-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		4 / 6 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.17A 2ejfB-3nwpA:
undetectable		 2ejfB-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		4 / 7 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.15A 2ejgA-3nwpA:
undetectable		 2ejgA-3nwpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		4 / 7 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.22A 2ejgB-3nwpA:
undetectable		 2ejgB-3nwpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.76A 2hxfB-3nwpA:
undetectable		 2hxfB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.76A 2hxhB-3nwpA:
undetectable		 2hxhB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.75A 2p4nB-3nwpA:
undetectable		 2p4nB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.75A 2wbeB-3nwpA:
undetectable		 2wbeB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 7 TRP A  74
GLU A  72
ALA A 115
ASN A 106
ALA A 118
 None
 1.22A 2zgwA-3nwpA:
undetectable		 2zgwA-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 6 TRP A  74
GLU A  72
ALA A 115
ASN A 106
ALA A 118
 None
 1.25A 2zgwB-3nwpA:
undetectable		 2zgwB-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.76A 3dcoB-3nwpA:
undetectable		 3dcoB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.75A 3edlB-3nwpA:
undetectable		 3edlB-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A 104
LEU A 177
THR A 176
ARG A  73
GLY A 135
 None
 0.72A 3iz0B-3nwpA:
undetectable		 3iz0B-3nwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 LEU A  28
VAL A  42
TYR A 189
PHE A  52
LEU A  55
 None
 1.49A 3meeA-3nwpA:
undetectable		 3meeA-3nwpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 11 PRO A 147
THR A 169
PRO A 171
ARG A 174
PRO A 167
 None
 1.26A 3t8nD-3nwpA:
undetectable
3t8nF-3nwpA:
undetectable		 3t8nD-3nwpA:
23.08
3t8nF-3nwpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 11 THR A 169
PRO A 171
ARG A 174
PRO A 167
PRO A 147
 None
 1.26A 3t8nD-3nwpA:
undetectable
3t8nF-3nwpA:
undetectable		 3t8nD-3nwpA:
23.08
3t8nF-3nwpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 ILE A 188
VAL A 132
LEU A 134
ALA A 181
LEU A 183
 None
 0.94A 4m11B-3nwpA:
undetectable		 4m11B-3nwpA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 11 ILE A 188
PHE A 129
VAL A 218
ASP A  71
ALA A 181
 None
 1.09A 5lg3A-3nwpA:
undetectable		 5lg3A-3nwpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nwp 6-PHOSPHOGLUCONOLACT
ONASE
(Shewanella
baltica) 		5 / 12 ILE A 188
PHE A 129
VAL A 218
ASP A  71
ALA A 181
 None
 1.11A 5lg3E-3nwpA:
undetectable		 5lg3E-3nwpA:
20.81