SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 LEU A 110
LEU A 134
ARG A 133
SER A 131
ALA A  17
 None
 1.11A 1h9zA-3nwrA:
undetectable		 1h9zA-3nwrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 ASP A  18
LEU A 130
GLU A  65
ARG A 133
 None
 0.96A 1mt1A-3nwrA:
undetectable
1mt1F-3nwrA:
undetectable		 1mt1A-3nwrA:
8.00
1mt1F-3nwrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 5 GLU A  65
ARG A 133
ASP A  18
LEU A 130
 None
 0.92A 1n13B-3nwrA:
undetectable
1n13C-3nwrA:
undetectable		 1n13B-3nwrA:
12.53
1n13C-3nwrA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 8 ASP A  18
LEU A 130
GLU A  65
ARG A 133
 None
 0.91A 1n13A-3nwrA:
undetectable
1n13F-3nwrA:
undetectable		 1n13A-3nwrA:
8.00
1n13F-3nwrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 GLU A  65
ARG A 133
ASP A  18
LEU A 130
 None
 0.94A 1n13H-3nwrA:
undetectable
1n13K-3nwrA:
undetectable		 1n13H-3nwrA:
12.53
1n13K-3nwrA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 7 ASP A  18
LEU A 130
GLU A  65
ARG A 133
 None
 0.89A 1n13I-3nwrA:
undetectable
1n13L-3nwrA:
undetectable		 1n13I-3nwrA:
8.00
1n13L-3nwrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.22A 1usqB-3nwrA:
undetectable		 1usqB-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.23A 1usqC-3nwrA:
undetectable		 1usqC-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.22A 1usqD-3nwrA:
undetectable		 1usqD-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.21A 1usqE-3nwrA:
undetectable		 1usqE-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 7 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.21A 1usqF-3nwrA:
undetectable		 1usqF-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		3 / 3 ASP A 192
ARG A 399
ASP A 157
 SO4  A 434 ( 4.8A)
SO4  A 434 (-3.1A)
None
 0.60A 1vptA-3nwrA:
undetectable		 1vptA-3nwrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 PHE A 428
GLY A 383
LEU A 411
LEU A 421
ALA A 401
 GOL  A 437 ( 4.7A)
GOL  A 437 (-3.9A)
None
None
None
 0.97A 2egvA-3nwrA:
3.5		 2egvA-3nwrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 VAL A  33
MET A  34
ILE A  94
MET A 299
 None
 1.02A 2hyyC-3nwrA:
undetectable		 2hyyC-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.28A 2jkjA-3nwrA:
undetectable		 2jkjA-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.28A 2jkjB-3nwrA:
undetectable		 2jkjB-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.28A 2jkjC-3nwrA:
undetectable		 2jkjC-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 7 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.26A 2jkjE-3nwrA:
undetectable		 2jkjE-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 6 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.25A 2jklB-3nwrA:
undetectable		 2jklB-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 7 PRO A 388
GLY A 390
PRO A 391
ILE A 384
GLY A 394
 None
 1.24A 2jklE-3nwrA:
undetectable		 2jklE-3nwrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 ALA A 354
GLY A 165
ILE A 164
THR A 152
VAL A 149
 None
None
None
None
GOL  A 436 (-3.9A)
 0.95A 2nnpA-3nwrA:
undetectable		 2nnpA-3nwrA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 LEU A  15
LEU A 134
ARG A 133
LEU A 129
ASP A  18
 None
 0.91A 2q72A-3nwrA:
undetectable		 2q72A-3nwrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 LEU A  15
LEU A 134
ARG A 133
LEU A 129
ASP A  18
 None
 0.90A 2qeiA-3nwrA:
undetectable		 2qeiA-3nwrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 LEU A  15
LEU A 134
ARG A 133
LEU A 129
ASP A  18
 None
 0.90A 2qjuA-3nwrA:
undetectable		 2qjuA-3nwrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 10 LEU A 107
LEU A 110
LEU A 132
LEU A 307
ARG A 309
 None
 1.08A 2xn7A-3nwrA:
undetectable
2xn7B-3nwrA:
undetectable		 2xn7A-3nwrA:
21.52
2xn7B-3nwrA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 4 VAL A 127
ARG A  29
ILE A  64
THR A 125
 None
SO4  A 435 (-4.0A)
None
None
 1.34A 3cl9A-3nwrA:
undetectable		 3cl9A-3nwrA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 GLY A 165
LEU A 377
SER A 357
HIS A 319
ALA A 354
 None
None
SO4  A 433 ( 4.7A)
None
None
 1.27A 3d91A-3nwrA:
undetectable		 3d91A-3nwrA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		3 / 3 SER A 311
GLN A 271
PHE A 142
 None
 0.56A 3g4lC-3nwrA:
undetectable		 3g4lC-3nwrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 GLY A 394
VAL A 158
GLY A 165
SER A 380
ILE A 164
 None
 1.21A 3k13A-3nwrA:
7.7		 3k13A-3nwrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 GLY A 394
VAL A 158
GLY A 165
SER A 380
ILE A 164
 None
 1.20A 3k13B-3nwrA:
10.1		 3k13B-3nwrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 GLY A 394
VAL A 158
GLY A 165
SER A 380
ILE A 164
 None
 1.20A 3k13C-3nwrA:
6.6		 3k13C-3nwrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 7 PHE A 378
PHE A 355
GLY A 381
PHE A 368
 None
None
SO4  A 433 (-3.5A)
None
 1.13A 3ko0R-3nwrA:
undetectable
3ko0T-3nwrA:
undetectable		 3ko0R-3nwrA:
14.39
3ko0T-3nwrA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 8 LEU A  25
ARG A  90
ALA A  69
GLY A  84
 SO4  A 435 (-3.9A)
None
None
None
 0.81A 3ny4A-3nwrA:
undetectable		 3ny4A-3nwrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 ALA A 296
ASP A 294
LEU A  75
THR A 125
 None
 1.02A 3rozA-3nwrA:
undetectable		 3rozA-3nwrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		6 / 12 LEU A 376
LEU A 321
GLY A 320
PHE A 355
ILE A 333
ALA A 330
 None
None
None
None
GOL  A 440 (-4.4A)
None
 1.46A 3uwlB-3nwrA:
undetectable		 3uwlB-3nwrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		6 / 12 LEU A 376
LEU A 321
GLY A 320
PHE A 355
ILE A 333
ALA A 330
 None
None
None
None
GOL  A 440 (-4.4A)
None
 1.46A 3uwlD-3nwrA:
undetectable		 3uwlD-3nwrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 ARG A 153
SER A 373
VAL A 318
HIS A 317
HIS A 282
 None
None
None
KCX  A 195 ( 4.7A)
KCX  A 195 ( 4.6A)
 1.49A 3vt7A-3nwrA:
undetectable		 3vt7A-3nwrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		3 / 3 ASP A 192
ARG A 399
ASP A 157
 SO4  A 434 ( 4.8A)
SO4  A 434 (-3.1A)
None
 0.82A 4fzvA-3nwrA:
undetectable		 4fzvA-3nwrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 GLY A 382
GLY A 381
ALA A 386
LEU A 385
HIS A 387
 GOL  A 437 ( 3.6A)
SO4  A 433 (-3.5A)
None
None
None
 1.07A 4l8fB-3nwrA:
undetectable		 4l8fB-3nwrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 11 GLY A 382
GLY A 381
ALA A 386
LEU A 385
HIS A 387
 GOL  A 437 ( 3.6A)
SO4  A 433 (-3.5A)
None
None
None
 1.09A 4l8fD-3nwrA:
undetectable		 4l8fD-3nwrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		6 / 12 VAL A 114
LEU A  15
ALA A  59
SER A  60
LEU A  96
LEU A  62
 None
 1.10A 4m11B-3nwrA:
undetectable		 4m11B-3nwrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		3 / 3 ALA A 386
GLN A 359
GLY A 320
 None
 0.58A 4odoC-3nwrA:
1.4		 4odoC-3nwrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 7 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.94A 4w5oA-3nwrA:
undetectable		 4w5oA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		3 / 3 ASP A 389
ARG A 422
PRO A 419
 None
 0.70A 4wanC-3nwrA:
undetectable		 4wanC-3nwrA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 10 GLY A 126
ASP A 120
TYR A 119
LEU A 297
LEU A  75
 None
 1.11A 4xj7A-3nwrA:
undetectable
4xj7B-3nwrA:
undetectable		 4xj7A-3nwrA:
23.54
4xj7B-3nwrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 ASP A 238
THR A 277
PRO A 278
VAL A 258
 GOL  A 439 (-3.0A)
None
None
None
 1.08A 4yoaA-3nwrA:
undetectable		 4yoaA-3nwrA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 7 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.94A 4z4eA-3nwrA:
undetectable		 4z4eA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 7 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.93A 4z4gA-3nwrA:
2.1		 4z4gA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 5 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.96A 4z4hA-3nwrA:
undetectable		 4z4hA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 9 SER A 380
GLY A 165
ALA A 189
VAL A 191
ILE A 194
 None
None
None
None
KCX  A 195 ( 3.8A)
 1.22A 5i3cA-3nwrA:
undetectable		 5i3cA-3nwrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 10 SER A 380
GLY A 165
ALA A 189
VAL A 191
ILE A 194
 None
None
None
None
KCX  A 195 ( 3.8A)
 1.21A 5i3cB-3nwrA:
undetectable		 5i3cB-3nwrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 THR A 113
GLN A  38
VAL A  33
VAL A  30
SER A  40
 None
 1.37A 6bzoC-3nwrA:
undetectable		 6bzoC-3nwrA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		4 / 6 LEU A 307
LEU A  15
THR A 109
ARG A  58
 None
 1.06A 6ew0G-3nwrA:
undetectable		 6ew0G-3nwrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3nwr A RUBISCO-LIKE
PROTEIN
(Paraburkholderia
fungorum) 		5 / 12 LEU A 376
LEU A 321
GLY A 320
ILE A 333
ALA A 330
 None
None
None
GOL  A 440 (-4.4A)
None
 1.16A 6qxsD-3nwrA:
undetectable		 6qxsD-3nwrA:
21.78