SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 209
LEU A 364
ILE A 342
GLY A 341
LEU A 267
 None
 0.82A 1eqhA-3nwuA:
undetectable		 1eqhA-3nwuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 THR A 291
ILE A 342
GLY A 329
GLY A 204
ASN A 327
 None
 1.13A 1nv8A-3nwuA:
undetectable		 1nv8A-3nwuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 VAL A 333
VAL A 280
ASN A 334
GLU A 277
GLU A 338
 None
 1.15A 1t6zA-3nwuA:
2.2		 1t6zA-3nwuA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 9 ILE A 282
ALA A 173
VAL A 176
GLU A 177
 None
 0.86A 2vufA-3nwuA:
undetectable		 2vufA-3nwuA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 7 VAL A 221
HIS A 185
ILE A 342
ASN A 218
 None
None
None
SO4  A   1 (-3.0A)
 1.06A 3avpA-3nwuA:
undetectable		 3avpA-3nwuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 GLY A 276
THR A 319
ILE A 317
LEU A 273
THR A 300
 None
 1.33A 3bexC-3nwuA:
undetectable
3bexD-3nwuA:
undetectable		 3bexC-3nwuA:
23.97
3bexD-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 10 LEU A 273
THR A 300
GLY A 276
THR A 319
ILE A 317
 None
 1.33A 3bexC-3nwuA:
undetectable
3bexD-3nwuA:
undetectable		 3bexC-3nwuA:
23.97
3bexD-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 10 GLY A 276
THR A 319
ILE A 317
LEU A 273
THR A 300
 None
 1.34A 3bexE-3nwuA:
undetectable
3bexF-3nwuA:
undetectable		 3bexE-3nwuA:
23.97
3bexF-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 LEU A 273
THR A 300
GLY A 276
THR A 319
ILE A 317
 None
 1.33A 3bexE-3nwuA:
undetectable
3bexF-3nwuA:
undetectable		 3bexE-3nwuA:
23.97
3bexF-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 GLY A 276
THR A 319
ILE A 317
LEU A 273
THR A 300
 None
 1.37A 3bf1A-3nwuA:
undetectable
3bf1B-3nwuA:
undetectable		 3bf1A-3nwuA:
23.97
3bf1B-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 GLY A 276
THR A 319
ILE A 317
LEU A 273
THR A 300
 None
 1.32A 3bf1C-3nwuA:
undetectable
3bf1D-3nwuA:
undetectable		 3bf1C-3nwuA:
23.97
3bf1D-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 LEU A 273
THR A 300
GLY A 276
THR A 319
ILE A 317
 None
 1.36A 3bf1C-3nwuA:
undetectable
3bf1D-3nwuA:
undetectable		 3bf1C-3nwuA:
23.97
3bf1D-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 GLY A 276
THR A 319
ILE A 317
LEU A 273
THR A 300
 None
 1.34A 3bf1E-3nwuA:
undetectable
3bf1F-3nwuA:
undetectable		 3bf1E-3nwuA:
23.97
3bf1F-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 11 LEU A 273
THR A 300
GLY A 276
THR A 319
ILE A 317
 None
 1.33A 3bf1E-3nwuA:
undetectable
3bf1F-3nwuA:
undetectable		 3bf1E-3nwuA:
23.97
3bf1F-3nwuA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 4 THR A 293
VAL A 333
GLY A 329
THR A 217
 None
 0.90A 3cflA-3nwuA:
undetectable		 3cflA-3nwuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 209
LEU A 364
GLY A 341
SER A 357
LEU A 267
 None
 1.26A 3pghA-3nwuA:
undetectable		 3pghA-3nwuA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 ILE A 296
LEU A 265
GLY A 341
ASN A 343
ILE A 340
 None
 0.99A 4o1eB-3nwuA:
undetectable		 4o1eB-3nwuA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 9 ALA A 281
SER A 270
GLY A 341
ALA A 354
VAL A 297
 None
 1.21A 4r1zA-3nwuA:
undetectable		 4r1zA-3nwuA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 GLY A 295
LEU A 265
GLY A 341
ASN A 343
ILE A 340
 None
 1.07A 5vopA-3nwuA:
undetectable		 5vopA-3nwuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 ASN A 290
GLY A 206
ILE A 282
GLU A 231
VAL A 184
 None
 0.98A 6ectA-3nwuA:
undetectable		 6ectA-3nwuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3nwu SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 230
ILE A 186
SER A 210
VAL A 216
ILE A 254
 None
 1.39A 6gsdA-3nwuA:
undetectable		 6gsdA-3nwuA:
17.54