SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 PHE A  42
LEU A 111
GLY A  38
ALA A 184
LEU A  35
 None
 1.14A 1e7bA-3nwyA:
undetectable		 1e7bA-3nwyA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  73
VAL A  57
LEU A 111
ILE A 246
LEU A  37
 None
 1.07A 1eqgA-3nwyA:
undetectable		 1eqgA-3nwyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  73
VAL A  57
LEU A 111
ILE A 246
LEU A  37
 None
 1.09A 1eqgB-3nwyA:
undetectable		 1eqgB-3nwyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 246
LEU A 111
VAL A  73
ILE A  71
 None
 0.91A 1fm6D-3nwyA:
undetectable		 1fm6D-3nwyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 155
ILE A 153
GLY A  38
THR A 168
ALA A 169
 None
 1.08A 1jg2A-3nwyA:
3.8		 1jg2A-3nwyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  77
GLY A  43
PHE A  42
LEU A  49
GLY A  48
 None
 1.30A 1l5mA-3nwyA:
undetectable		 1l5mA-3nwyA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 103
GLY A  43
PHE A  42
LEU A  49
GLY A  48
 None
 1.12A 1l5mA-3nwyA:
undetectable		 1l5mA-3nwyA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  78
SER A 108
VAL A  74
LEU A  37
GLY A  38
GLY A  39
 None
 1.18A 1uakA-3nwyA:
undetectable		 1uakA-3nwyA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 219
SER A 164
VAL A 181
HIS A 209
LEU A 258
 None
 1.29A 2hc4A-3nwyA:
undetectable		 2hc4A-3nwyA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  57
ALA A  58
VAL A  65
VAL A 151
VAL A  64
 None
 1.00A 2nnjA-3nwyA:
undetectable		 2nnjA-3nwyA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  79
GLY A  43
VAL A  57
LEU A 111
PHE A  80
 None
 1.34A 3mnoA-3nwyA:
undetectable		 3mnoA-3nwyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  79
GLY A  43
VAL A  57
LEU A 111
PHE A  80
 None
 1.30A 3mnpA-3nwyA:
undetectable		 3mnpA-3nwyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 184
LEU A  35
THR A 122
VAL A 124
VAL A 105
 None
 1.24A 3r9cA-3nwyA:
undetectable		 3r9cA-3nwyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 155
THR A 126
SER A 108
VAL A 105
 None
 0.68A 5ewuA-3nwyA:
undetectable		 5ewuA-3nwyA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 155
THR A 126
SER A 108
VAL A 105
 None
 0.88A 5ewuB-3nwyA:
undetectable		 5ewuB-3nwyA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3nwy URIDYLATE KINASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  78
SER A 108
VAL A  74
LEU A  37
GLY A  38
GLY A  39
 None
 1.16A 5zhmB-3nwyA:
undetectable		 5zhmB-3nwyA:
26.52