SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
3 / 3 SER A  23
GLU A  22
GLU A  21
None
0.68A 1eqbD-3nx4A:
undetectable
1eqbD-3nx4A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
3 / 3 SER A  23
GLU A  22
GLU A  21
None
0.68A 1eqbB-3nx4A:
undetectable
1eqbB-3nx4A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 GLY A 160
THR A 162
ALA A 294
GLY A 125
ALA A 295
None
0.97A 1gtnL-3nx4A:
undetectable
1gtnV-3nx4A:
undetectable
1gtnL-3nx4A:
13.89
1gtnV-3nx4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 ARG A 180
ASP A 199
ILE A 195
ALA A 192
ARG A 198
NAP  A 330 (-4.0A)
None
None
None
NAP  A 330 (-3.6A)
1.19A 1kijB-3nx4A:
undetectable
1kijB-3nx4A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 11 ILE A  53
LEU A  39
PRO A  61
LEU A   6
VAL A 315
None
1.29A 1mrlA-3nx4A:
undetectable
1mrlB-3nx4A:
undetectable
1mrlA-3nx4A:
20.53
1mrlB-3nx4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 ILE A  53
LEU A  39
PRO A  61
LEU A   6
VAL A 315
None
1.29A 1mrlB-3nx4A:
undetectable
1mrlC-3nx4A:
undetectable
1mrlB-3nx4A:
20.53
1mrlC-3nx4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 5 ASP A  43
LEU A   6
ALA A 307
LEU A  39
None
1.13A 1nh8A-3nx4A:
undetectable
1nh8A-3nx4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 11 GLY A 125
ALA A 295
GLY A 160
THR A 162
ALA A 294
None
1.03A 1utdP-3nx4A:
undetectable
1utdQ-3nx4A:
undetectable
1utdP-3nx4A:
13.89
1utdQ-3nx4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 8 THR A 319
GLY A 125
THR A 126
ALA A 127
None
None
NAP  A 330 (-4.7A)
NAP  A 330 ( 4.2A)
0.77A 2a1hA-3nx4A:
undetectable
2a1hB-3nx4A:
undetectable
2a1hA-3nx4A:
24.49
2a1hB-3nx4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 6 LEU A  20
LEU A  25
MET A   1
GLU A 100
None
1.22A 2kuhA-3nx4A:
undetectable
2kuhA-3nx4A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 8 VAL A 152
ARG A 318
GLY A 317
ALA A 294
None
0.92A 2xfsA-3nx4A:
undetectable
2xfsA-3nx4A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 8 VAL A 152
ARG A 318
GLY A 317
ALA A 294
None
0.91A 2xh9A-3nx4A:
undetectable
2xh9A-3nx4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 9 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
None
NAP  A 330 (-3.4A)
NAP  A 330 (-3.2A)
None
None
0.93A 2z0yA-3nx4A:
2.5
2z0yA-3nx4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 9 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
None
NAP  A 330 (-3.4A)
NAP  A 330 (-3.2A)
None
None
0.94A 2z0yB-3nx4A:
2.8
2z0yB-3nx4A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 7 GLY A  62
ALA A 102
ALA A  99
VAL A 104
None
0.78A 3a2qA-3nx4A:
undetectable
3a2qA-3nx4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
3 / 3 GLY A  97
GLY A  91
GLY A  62
None
0.42A 3bogC-3nx4A:
undetectable
3bogC-3nx4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 11 LEU A   4
ILE A  60
PRO A  61
GLY A  97
SER A  37
None
1.40A 3bpxA-3nx4A:
undetectable
3bpxB-3nx4A:
undetectable
3bpxA-3nx4A:
16.82
3bpxB-3nx4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 4 ARG A  76
ASP A  29
ASP A  74
PRO A  75
None
1.08A 3fgrB-3nx4A:
undetectable
3fgrB-3nx4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 GLY A 157
GLY A 317
ILE A 195
SER A 182
SER A 178
NAP  A 330 (-3.2A)
None
None
None
NAP  A 330 (-2.4A)
1.06A 3nk7A-3nx4A:
2.4
3nk7A-3nx4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 9 ILE A  47
ALA A   3
LEU A   4
LEU A  39
ALA A  44
None
1.05A 3ozvB-3nx4A:
4.5
3ozvB-3nx4A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
3 / 3 ASN A  40
ALA A 127
ARG A 318
None
NAP  A 330 ( 4.2A)
None
0.82A 3tj7C-3nx4A:
undetectable
3tj7D-3nx4A:
undetectable
3tj7C-3nx4A:
19.51
3tj7D-3nx4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 6 ARG A  76
VAL A 104
PHE A  77
GLU A  73
None
1.46A 3ufrA-3nx4A:
undetectable
3ufrB-3nx4A:
undetectable
3ufrA-3nx4A:
21.77
3ufrB-3nx4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 LEU A  14
ALA A  15
LEU A  98
ILE A  60
GLY A  62
None
1.07A 4dm8B-3nx4A:
undetectable
4dm8B-3nx4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 4 SER A 117
TYR A 291
GLY A 115
PRO A 113
None
1.48A 4e3aA-3nx4A:
3.2
4e3aA-3nx4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A  34
ALA A  99
LEU A  25
PHE A  65
LEU A 109
None
1.21A 4eckA-3nx4A:
undetectable
4eckA-3nx4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A  34
ALA A  99
LEU A  25
PHE A  65
LEU A 109
None
1.16A 4eckB-3nx4A:
undetectable
4eckB-3nx4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A  34
ALA A  99
PHE A  65
LEU A 109
VAL A  32
None
1.03A 4eckB-3nx4A:
undetectable
4eckB-3nx4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 LEU A  98
GLY A  96
MET A  59
LEU A   6
THR A 126
None
None
None
None
NAP  A 330 (-4.7A)
1.45A 4p6xE-3nx4A:
undetectable
4p6xE-3nx4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 ASP A  64
SER A 118
LEU A 109
PHE A  65
GLY A  67
None
1.30A 4pevC-3nx4A:
3.9
4pevC-3nx4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 ALA A 176
VAL A 152
LEU A 282
ALA A 165
LEU A 170
None
1.12A 4qrcA-3nx4A:
undetectable
4qrcA-3nx4A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 GLY A  91
GLY A  96
GLY A  97
LEU A  98
ASP A  43
None
0.97A 5c0oF-3nx4A:
6.2
5c0oF-3nx4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
None
NAP  A 330 (-3.5A)
NAP  A 330 (-3.8A)
None
None
1.08A 5kirA-3nx4A:
undetectable
5kirA-3nx4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
None
NAP  A 330 (-3.5A)
NAP  A 330 (-3.8A)
None
None
1.07A 5kirB-3nx4A:
undetectable
5kirB-3nx4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 THR A 296
GLY A 317
ILE A 298
SER A  38
LEU A  39
None
1.04A 5l0zA-3nx4A:
undetectable
5l0zA-3nx4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 GLY A 317
GLY A 128
GLY A 157
THR A 130
ILE A 124
None
None
NAP  A 330 (-3.2A)
NAP  A 330 (-3.3A)
None
1.03A 5wz1A-3nx4A:
3.5
5wz1A-3nx4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
5 / 12 VAL A 321
GLY A  62
ILE A  53
GLU A  92
ALA A  44
None
1.00A 5x7fA-3nx4A:
7.2
5x7fA-3nx4A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 5 GLY A 220
ASP A 221
ARG A 198
GLN A 230
None
None
NAP  A 330 (-3.6A)
None
1.26A 5zrfB-3nx4A:
undetectable
5zrfB-3nx4A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 7 ILE A   5
LEU A   6
ILE A 323
ALA A 307
None
0.84A 6b5vA-3nx4A:
undetectable
6b5vC-3nx4A:
undetectable
6b5vA-3nx4A:
14.24
6b5vC-3nx4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 7 ILE A   5
LEU A   6
ILE A 323
ALA A 307
None
0.84A 6b5vC-3nx4A:
undetectable
6b5vD-3nx4A:
undetectable
6b5vC-3nx4A:
14.24
6b5vD-3nx4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica)
4 / 7 ALA A 307
ILE A   5
LEU A   6
ILE A 323
None
0.85A 6b5vB-3nx4A:
undetectable
6b5vD-3nx4A:
undetectable
6b5vB-3nx4A:
14.24
6b5vD-3nx4A:
14.24