SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 8 TYR A 184
HIS A  36
GLY A 175
ILE A 174
 None
CO3  A 477 (-4.0A)
None
None
 0.82A 2zm9A-3nxlA:
undetectable		 2zm9A-3nxlA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 8 PRO A 205
ALA A 209
ALA A 212
GLU A 238
 None
 0.74A 3dtuC-3nxlA:
undetectable
3dtuD-3nxlA:
undetectable		 3dtuC-3nxlA:
21.96
3dtuD-3nxlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 9 HIS A 359
ASP A 386
HIS A 388
ASP A 255
GLU A 280
 MG  A 476 ( 4.5A)
None
CO3  A 477 (-4.0A)
MG  A 476 (-2.8A)
MG  A 476 (-3.3A)
 1.49A 3gn0A-3nxlA:
undetectable		 3gn0A-3nxlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 6 GLY A  55
GLN A 146
ILE A  46
VAL A  56
 None
 1.08A 3kvvC-3nxlA:
undetectable		 3kvvC-3nxlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 6 GLY A  55
GLN A 146
ILE A  46
VAL A  56
 None
 1.15A 3kvvF-3nxlA:
undetectable		 3kvvF-3nxlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 ILE A 390
ALA A 212
LEU A 226
ILE A 174
LEU A  29
 None
 1.19A 3ql0A-3nxlA:
undetectable		 3ql0A-3nxlA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		3 / 3 HIS A 359
SER A 367
ASN A 362
 MG  A 476 ( 4.5A)
None
CO3  A 477 ( 4.8A)
 0.90A 3s8pB-3nxlA:
0.0		 3s8pB-3nxlA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 5 ARG A  92
THR A 134
GLN A 340
GLU A 137
 None
 1.49A 4eahA-3nxlA:
0.0
4eahE-3nxlA:
0.0
4eahG-3nxlA:
0.9		 4eahA-3nxlA:
22.33
4eahE-3nxlA:
22.33
4eahG-3nxlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 VAL A 343
ALA A 138
LEU A 155
LEU A 156
LEU A  88
 None
 1.09A 4i1rA-3nxlA:
undetectable		 4i1rA-3nxlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 8 ILE A 382
ALA A 374
VAL A 165
PRO A 166
 None
 0.66A 4jltA-3nxlA:
undetectable		 4jltA-3nxlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 8 HIS A 335
PRO A 334
ASP A 333
SER A 358
 None
 1.05A 4l7iB-3nxlA:
undetectable		 4l7iB-3nxlA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 ILE A 390
ALA A 212
LEU A 226
ILE A 174
LEU A  29
 None
 1.19A 4qlgA-3nxlA:
undetectable		 4qlgA-3nxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 VAL A 152
LEU A 156
LEU A  88
TYR A  84
ALA A 138
 None
 1.02A 4rrxA-3nxlA:
undetectable		 4rrxA-3nxlA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 VAL A 152
LEU A 156
LEU A  88
TYR A  84
ALA A 138
 None
 1.09A 4rrxB-3nxlA:
undetectable		 4rrxB-3nxlA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 6 SER A 261
LEU A 262
ASP A 263
TYR A 289
 None
 0.97A 4wozA-3nxlA:
6.6
4wozB-3nxlA:
11.8		 4wozA-3nxlA:
21.51
4wozB-3nxlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 8 VAL A 152
LEU A 156
LEU A  88
ALA A 138
 None
 0.76A 5f1aA-3nxlA:
undetectable		 5f1aA-3nxlA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		3 / 3 TRP A 260
GLU A 236
ASP A 255
 None
None
MG  A 476 (-2.8A)
 0.50A 5gqbA-3nxlA:
5.1		 5gqbA-3nxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 ASN A  43
LEU A  69
GLY A  57
ALA A 138
LEU A  88
 None
 1.22A 5x23A-3nxlA:
undetectable		 5x23A-3nxlA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 7 ASN A 309
ASP A 281
GLY A 228
ASN A 257
 MG  A 476 (-2.4A)
None
None
MG  A 476 ( 4.3A)
 1.13A 5x7pA-3nxlA:
undetectable		 5x7pA-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 7 HIS A  36
ASP A 255
GLY A 228
ASN A  31
 CO3  A 477 (-4.0A)
MG  A 476 (-2.8A)
None
CO3  A 477 ( 3.8A)
 1.12A 5x7pA-3nxlA:
undetectable		 5x7pA-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 5 HIS A  36
ASP A 255
GLY A 228
ASN A  31
 CO3  A 477 (-4.0A)
MG  A 476 (-2.8A)
None
CO3  A 477 ( 3.8A)
 1.12A 5x7pB-3nxlA:
undetectable		 5x7pB-3nxlA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 4 GLY A  57
LEU A  44
VAL A 366
GLU A  58
 None
 1.28A 5yw0A-3nxlA:
undetectable		 5yw0A-3nxlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 4 GLN A 426
VAL A  22
ARG A 415
ARG A 397
 None
 1.05A 6brdA-3nxlA:
undetectable		 6brdA-3nxlA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 10 VAL A 230
LEU A  32
SER A 463
LEU A 451
GLY A 175
 None
 1.20A 6eu9B-3nxlA:
undetectable		 6eu9B-3nxlA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 5 LEU A 398
THR A  41
PRO A 183
ARG A 177
 None
 1.09A 6ew0F-3nxlA:
2.3		 6ew0F-3nxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		4 / 6 LEU A 398
THR A  41
PRO A 183
ARG A 177
 None
 1.08A 6ew0G-3nxlA:
2.3		 6ew0G-3nxlA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 ALA A 332
TRP A 356
GLY A 380
GLU A 158
TRP A 315
 None
 1.33A 6fhwA-3nxlA:
undetectable		 6fhwA-3nxlA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 3nxl GLUCARATE
DEHYDRATASE
(Burkholderia
lata) 		5 / 12 ALA A 332
TRP A 356
GLY A 380
GLU A 158
TRP A 315
 None
 1.33A 6fhwB-3nxlA:
undetectable		 6fhwB-3nxlA:
10.11