SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 HIS A 457
SER A 595
VAL A 613
GLY A 626
 None
 0.49A 1aq7A-3nxpA:
23.2		 1aq7A-3nxpA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.43A 1ceaA-3nxpA:
undetectable
1ceaB-3nxpA:
undetectable		 1ceaA-3nxpA:
11.00
1ceaB-3nxpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.40A 1ceaB-3nxpA:
undetectable		 1ceaB-3nxpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.48A 1cebA-3nxpA:
undetectable		 1cebA-3nxpA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 7 ASP A 223
ASP A 225
TRP A 230
TYR A 232
 None
 0.50A 1cebB-3nxpA:
undetectable		 1cebB-3nxpA:
11.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 9 HIS A 457
TYR A 460
ILE A 574
SER A 595
GLY A 626
 None
 0.85A 1dwcH-3nxpA:
29.3		 1dwcH-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 12 HIS A 457
TYR A 460
LEU A 499
VAL A 613
GLY A 626
 None
 0.57A 1etrH-3nxpA:
29.6		 1etrH-3nxpA:
87.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 GLU A 309
LYS A 602
GLU A 305
GLU A 300
 None
 1.00A 1knyA-3nxpA:
undetectable
1knyB-3nxpA:
undetectable		 1knyA-3nxpA:
19.86
1knyB-3nxpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 SER A 595
ILE A 612
GLY A 611
GLY A 626
 None
 0.78A 1me7A-3nxpA:
undetectable		 1me7A-3nxpA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		3 / 3 LEU A 505
LEU A 453
SER A 445
 None
 0.64A 1tlmA-3nxpA:
undetectable		 1tlmA-3nxpA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		6 / 11 HIS A 491
ARG A 493
TRP A 637
LYS A 640
VAL A 641
GLN A 644
 None
None
GOL  A 704 (-4.4A)
None
GOL  A 704 ( 4.4A)
GOL  A 704 (-3.0A)
 0.98A 2h9tH-3nxpA:
29.6		 2h9tH-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		7 / 11 HIS A 491
ARG A 493
ARG A 501
TRP A 637
LYS A 640
VAL A 641
GLN A 644
 None
None
None
GOL  A 704 (-4.4A)
None
GOL  A 704 ( 4.4A)
GOL  A 704 (-3.0A)
 1.01A 3bf6H-3nxpA:
29.8		 3bf6H-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		6 / 11 HIS A 491
ARG A 501
TRP A 637
VAL A 641
GLN A 644
GLU A 647
 None
None
GOL  A 704 (-4.4A)
GOL  A 704 ( 4.4A)
GOL  A 704 (-3.0A)
None
 1.09A 3bf6H-3nxpA:
29.8		 3bf6H-3nxpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 12 LEU A 560
ASN A 559
GLY A 536
TRP A 607
VAL A 417
 None
 1.50A 3gn8B-3nxpA:
undetectable		 3gn8B-3nxpA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 9 ASP A 223
ASP A 225
TRP A 230
TYR A 232
PHE A 240
 None
None
None
None
GOL  A 704 (-3.8A)
 0.62A 4bvvA-3nxpA:
0.0		 4bvvA-3nxpA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.84A 4fglD-3nxpA:
undetectable		 4fglD-3nxpA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 7 ASN A 221
GLY A 224
PHE A 280
PHE A 281
 None
 0.85A 4fglC-3nxpA:
undetectable		 4fglC-3nxpA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 12 HIS A 457
TYR A 460
TRP A 460
LEU A 499
GLY A 616
 None
 1.16A 4hfpB-3nxpA:
29.8		 4hfpB-3nxpA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		6 / 12 HIS A 457
TYR A 460
TRP A 460
LEU A 499
ILE A 574
GLY A 626
 None
 1.05A 4hfpB-3nxpA:
29.8		 4hfpB-3nxpA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		7 / 12 HIS A 457
TYR A 460
TRP A 460
LEU A 499
ILE A 574
VAL A 613
GLY A 626
 None
 0.73A 4hfpD-3nxpA:
29.6		 4hfpD-3nxpA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		6 / 10 ALA A 455
THR A 454
ALA A 504
ALA A 456
GLY A 611
THR A 629
 None
 1.45A 4qvyK-3nxpA:
undetectable
4qvyL-3nxpA:
undetectable		 4qvyK-3nxpA:
17.86
4qvyL-3nxpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		6 / 10 ALA A 455
THR A 454
ALA A 504
ALA A 456
GLY A 611
THR A 629
 None
 1.45A 4qvyY-3nxpA:
undetectable
4qvyZ-3nxpA:
undetectable		 4qvyY-3nxpA:
17.86
4qvyZ-3nxpA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 12 HIS A 457
TYR A 460
LEU A 499
VAL A 613
GLY A 626
 None
 0.50A 4rn6B-3nxpA:
36.6		 4rn6B-3nxpA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		5 / 12 HIS A 457
TYR A 460
TRP A 460
LEU A 499
GLY A 626
 None
 0.88A 4rn6B-3nxpA:
36.6		 4rn6B-3nxpA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 4 THR A 629
LEU A 499
HIS A 457
GLY A 616
 None
 1.46A 5gwyA-3nxpA:
9.0		 5gwyA-3nxpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 7 VAL A 600
VAL A 631
PRO A 524
TYR A 608
 None
 1.00A 5x80C-3nxpA:
undetectable
5x80D-3nxpA:
undetectable		 5x80C-3nxpA:
16.67
5x80D-3nxpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 5 GLY A 228
ASN A 221
ASP A 225
ARG A 633
 None
 1.33A 6dwdB-3nxpA:
undetectable
6dwdD-3nxpA:
undetectable		 6dwdB-3nxpA:
22.48
6dwdD-3nxpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 5 ARG A 633
GLY A 228
ASN A 221
ASP A 225
 None
 1.32A 6dwjB-3nxpA:
undetectable
6dwjD-3nxpA:
undetectable		 6dwjB-3nxpA:
22.48
6dwjD-3nxpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 ASP A 578
HIS A 491
ASP A 500
GLU A 497
 None
None
None
TRS  A 702 ( 3.9A)
 1.15A 6mn4B-3nxpA:
undetectable		 6mn4B-3nxpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3nxp PRETHROMBIN-1
(Homo
sapiens) 		4 / 8 ASP A 578
HIS A 491
ASP A 500
GLU A 497
 None
None
None
TRS  A 702 ( 3.9A)
 0.89A 6mn4C-3nxpA:
undetectable		 6mn4C-3nxpA:
20.96