SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 172
LEU A 174
GLY A  58
SER A  68
MET A 238
 None
None
None
GDP  A 327 (-2.7A)
None
 1.18A 1fdsA-3nxsA:
4.8		 1fdsA-3nxsA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 144
GLU A 137
ALA A  25
LEU A  22
VAL A   7
 None
 1.23A 1ictA-3nxsA:
undetectable
1ictC-3nxsA:
undetectable		 1ictA-3nxsA:
19.40
1ictC-3nxsA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 150
LEU A 142
GLY A 146
ALA A 117
ALA A  86
 None
 0.99A 2oc8A-3nxsA:
undetectable		 2oc8A-3nxsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 246
VAL A 259
LEU A 260
ARG A 232
 None
 0.90A 2oiqA-3nxsA:
undetectable		 2oiqA-3nxsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 142
LEU A  88
ILE A  14
PRO A 123
VAL A  29
 None
 1.20A 2po5A-3nxsA:
3.4		 2po5A-3nxsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  22
TYR A 118
ARG A 120
ILE A  26
 None
 0.79A 2q8hA-3nxsA:
undetectable		 2q8hA-3nxsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 196
ALA A 214
VAL A  57
ILE A  59
THR A 170
 None
 1.03A 3czhA-3nxsA:
undetectable		 3czhA-3nxsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ILE A 299
VAL A 303
ARG A 306
 None
 0.77A 3p73A-3nxsA:
undetectable		 3p73A-3nxsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 141
LEU A 142
TYR A 147
ALA A  21
ALA A  25
 None
 1.05A 3vw7A-3nxsA:
undetectable		 3vw7A-3nxsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A 292
ARG A 300
MET A 291
HIS A 293
 None
 1.42A 4g5jA-3nxsA:
undetectable		 4g5jA-3nxsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  58
GLU A 153
THR A 154
 None
 0.53A 4kouA-3nxsA:
1.6		 4kouA-3nxsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 151
VAL A 172
VAL A 168
TRP A 250
LEU A  74
 None
 1.35A 4q0bC-3nxsA:
0.5		 4q0bC-3nxsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A  40
GLN A  39
LEU A  44
LEU A  10
 None
 1.20A 4xoyA-3nxsA:
undetectable		 4xoyA-3nxsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  43
ALA A  25
ALA A  21
ALA A 144
 None
 0.66A 4z90F-3nxsA:
undetectable
4z90G-3nxsA:
undetectable
4z90H-3nxsA:
undetectable
4z90J-3nxsA:
undetectable		 4z90F-3nxsA:
21.20
4z90G-3nxsA:
21.20
4z90H-3nxsA:
21.20
4z90J-3nxsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		6 / 9 LEU A  47
LEU A  43
ALA A  25
LEU A  10
ALA A  21
ALA A 144
 None
 0.96A 4z91F-3nxsA:
undetectable
4z91G-3nxsA:
undetectable
4z91H-3nxsA:
undetectable
4z91I-3nxsA:
undetectable
4z91J-3nxsA:
undetectable		 4z91F-3nxsA:
21.20
4z91G-3nxsA:
21.20
4z91H-3nxsA:
21.20
4z91I-3nxsA:
21.20
4z91J-3nxsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 132
THR A 135
GLU A 137
ALA A 165
GLY A 166
 None
 1.15A 5lf3H-3nxsA:
undetectable
5lf3I-3nxsA:
undetectable		 5lf3H-3nxsA:
23.81
5lf3I-3nxsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3nxs LAO/AO TRANSPORT
SYSTEM ATPASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 132
THR A 135
GLU A 137
ALA A 165
GLY A 166
 None
 1.15A 5lf3V-3nxsA:
undetectable
5lf3W-3nxsA:
undetectable		 5lf3V-3nxsA:
23.81
5lf3W-3nxsA:
22.66