SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 204
LEU A 257
VAL A 294
ILE A 292
 None
 0.87A 1fm6D-3nybA:
undetectable		 1fm6D-3nybA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 183
GLN A 327
LEU A 232
ALA A 331
ILE A 324
 None
 1.11A 1g5yB-3nybA:
2.7		 1g5yB-3nybA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 373
LEU A 321
ILE A 324
ILE A 474
LEU A 475
 None
 1.18A 1kyvA-3nybA:
undetectable
1kyvE-3nybA:
undetectable		 1kyvA-3nybA:
17.37
1kyvE-3nybA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 474
LEU A 475
GLY A 373
LEU A 321
ILE A 324
 None
 1.19A 1kyvB-3nybA:
undetectable
1kyvC-3nybA:
undetectable		 1kyvB-3nybA:
17.37
1kyvC-3nybA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 443
PHE A 379
PHE A 380
ILE A 347
 None
 1.09A 2hjhA-3nybA:
undetectable		 2hjhA-3nybA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
PROTEIN AIR2
(Saccharomyces
cerevisiae) 		5 / 6 LEU B 145
VAL A 351
VAL A 374
ILE A 361
ARG A 319
 None
 1.42A 2hyyA-3nybB:
undetectable		 2hyyA-3nybB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 350
LEU A 342
VAL A 325
SER A 434
GLY A 384
 None
 1.39A 2vmyB-3nybA:
undetectable		 2vmyB-3nybA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 329
PHE A 447
LEU A 421
ILE A 440
SER A 437
 None
 1.45A 2ydoA-3nybA:
undetectable		 2ydoA-3nybA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
PROTEIN AIR2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 179
TRP B 140
LEU A 372
ASP A 177
 None
 1.33A 4aqlA-3nybA:
undetectable		 4aqlA-3nybA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
PROTEIN AIR2
(Saccharomyces
cerevisiae) 		4 / 6 ASP B 189
GLU A 381
ILE A 175
HIS A 462
 None
 1.10A 4xi3C-3nybB:
undetectable		 4xi3C-3nybB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 447
ILE A 443
PHE A 379
LEU A 394
PHE A 345
 None
 1.38A 5v5zA-3nybA:
undetectable		 5v5zA-3nybA:
21.50