SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A1194
VAL A1008
TRP A1181
 None
 0.70A 1bdwA-3nyfA:
undetectable
1bdwB-3nyfA:
undetectable		 1bdwA-3nyfA:
3.46
1bdwB-3nyfA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1047
LEU A1258
PRO A1261
ASN A1263
THR A1147
 None
 0.95A 2w3bB-3nyfA:
undetectable		 2w3bB-3nyfA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1047
LEU A1258
PRO A1261
ASN A1263
THR A1147
 None
 0.93A 2w3mA-3nyfA:
undetectable		 2w3mA-3nyfA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A1248
LEU A1244
ALA A1289
VAL A1127
VAL A1133
 None
 1.17A 3cwkA-3nyfA:
undetectable		 3cwkA-3nyfA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A1317
PHE A1325
VAL A1194
VAL A1327
 None
 0.99A 3kmoB-3nyfA:
undetectable		 3kmoB-3nyfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ASP A1095
GLU A1097
GLU A1098
ARG A1101
 None
 1.33A 3o0mA-3nyfA:
0.0		 3o0mA-3nyfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1354
PRO A1355
LEU A1358
 None
 0.48A 3w1wB-3nyfA:
undetectable		 3w1wB-3nyfA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A1008
ALA A1199
SER A1017
LEU A1155
VAL A1030
 None
FAD  A1500 (-3.8A)
None
None
None
 1.39A 4eilA-3nyfA:
undetectable		 4eilA-3nyfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A1008
ALA A1199
SER A1017
LEU A1155
VAL A1030
 None
FAD  A1500 (-3.8A)
None
None
None
 1.39A 4eilB-3nyfA:
undetectable		 4eilB-3nyfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A1008
ALA A1199
SER A1017
LEU A1155
VAL A1030
 None
FAD  A1500 (-3.8A)
None
None
None
 1.36A 4eilC-3nyfA:
undetectable		 4eilC-3nyfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A1008
ALA A1199
SER A1017
LEU A1155
VAL A1030
 None
FAD  A1500 (-3.8A)
None
None
None
 1.41A 4eilE-3nyfA:
undetectable		 4eilE-3nyfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A1334
ILE A1145
LEU A1150
PHE A1069
 FAD  A1500 (-3.3A)
None
None
None
 0.89A 4ejjD-3nyfA:
undetectable		 4ejjD-3nyfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A1198
GLY A1012
LEU A1061
LEU A1313
THR A1337
 None
FAD  A1500 (-3.5A)
None
None
None
 1.14A 4zmeA-3nyfA:
undetectable		 4zmeA-3nyfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A1125
LEU A1128
CYH A1235
LEU A1292
 None
 1.24A 5hrqB-3nyfA:
undetectable
5hrqI-3nyfA:
undetectable
5hrqJ-3nyfA:
undetectable		 5hrqB-3nyfA:
8.18
5hrqI-3nyfA:
5.48
5hrqJ-3nyfA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A1133
GLN A1120
CYH A1122
 None
 0.72A 5icxA-3nyfA:
undetectable
5icxE-3nyfA:
undetectable		 5icxA-3nyfA:
19.90
5icxE-3nyfA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A1030
GLU A1032
ALA A1016
THR A1337
GLY A1200
 None
FAD  A1500 (-2.6A)
None
None
FAD  A1500 (-3.5A)
 1.10A 5m5cB-3nyfA:
undetectable		 5m5cB-3nyfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A1030
GLU A1032
ALA A1016
THR A1337
GLY A1200
 None
FAD  A1500 (-2.6A)
None
None
FAD  A1500 (-3.5A)
 1.08A 5m5cE-3nyfA:
2.1		 5m5cE-3nyfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1145
ILE A1013
PHE A1069
SER A1065
THR A1042
 None
FAD  A1500 (-4.8A)
None
None
FAD  A1500 (-3.5A)
 1.22A 5tiwB-3nyfA:
undetectable		 5tiwB-3nyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A1153
THR A1042
GLY A1043
VAL A1030
ILE A1158
 None
FAD  A1500 (-3.5A)
None
None
None
 1.40A 5tuiB-3nyfA:
4.0		 5tuiB-3nyfA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3nyf D-ARGININE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A1177
LEU A1209
ARG A1176
ALA A1210
VAL A1212
 None
 1.36A 6c2mB-3nyfA:
undetectable		 6c2mB-3nyfA:
12.36