SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
VAL A 247
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.63A 1fmoE-3nyoA:
37.5		 1fmoE-3nyoA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 7 VAL A 247
MET A 266
ARG A 310
LEU A 318
 None
None
None
AMP  A 577 (-4.8A)
 0.78A 1iepB-3nyoA:
21.3		 1iepB-3nyoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.54A 1m17A-3nyoA:
24.5		 1m17A-3nyoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 PRO A 384
VAL A 401
TYR A 376
GLU A 406
 None
 1.41A 1m8dA-3nyoA:
undetectable		 1m8dA-3nyoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 PRO A 384
VAL A 401
TYR A 376
GLU A 406
 None
 1.43A 1m8dB-3nyoA:
undetectable		 1m8dB-3nyoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 PRO A 384
VAL A 401
TYR A 376
GLU A 406
 None
 1.41A 1m9jA-3nyoA:
undetectable		 1m9jA-3nyoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 PHE A 465
TYR A 473
PRO A 467
 None
 1.14A 1mcnA-3nyoA:
undetectable
1mcnB-3nyoA:
undetectable
1mcnP-3nyoA:
undetectable		 1mcnA-3nyoA:
16.17
1mcnB-3nyoA:
16.17
1mcnP-3nyoA:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 ARG A 440
ASP A 301
ASN A 242
 None
None
SO4  A 582 (-3.7A)
 0.66A 1nbhA-3nyoA:
undetectable		 1nbhA-3nyoA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 ARG A 440
ASP A 301
ASN A 242
 None
None
SO4  A 582 (-3.7A)
 0.66A 1nbhD-3nyoA:
undetectable		 1nbhD-3nyoA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
GLU A 234
LEU A 238
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 1.02A 1t46A-3nyoA:
21.4		 1t46A-3nyoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
AMP  A 577 (-4.8A)
 0.75A 1t46A-3nyoA:
21.4		 1t46A-3nyoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 9 LEU A 192
VAL A 200
ALA A 213
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.46A 1xbbA-3nyoA:
25.1		 1xbbA-3nyoA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
LEU A 238
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
None
None
AMP  A 577 ( 4.9A)
None
 1.17A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
LEU A 249
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
None
None
AMP  A 577 ( 4.9A)
None
 0.70A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 VAL A 200
LYS A 215
LEU A 249
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
 0.77A 1xkkA-3nyoA:
21.4		 1xkkA-3nyoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 10 LEU A 192
ALA A 213
LEU A 263
ASP A 270
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.77A 1yi4A-3nyoA:
27.8		 1yi4A-3nyoA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 200
VAL A 247
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 2eufB-3nyoA:
27.5		 2eufB-3nyoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.69A 2gqgA-3nyoA:
24.6		 2gqgA-3nyoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
 0.52A 2gqgB-3nyoA:
24.9		 2gqgB-3nyoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.54A 2itoA-3nyoA:
23.6		 2itoA-3nyoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.73A 2ityA-3nyoA:
19.9		 2ityA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.80A 2ityA-3nyoA:
19.9		 2ityA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.75A 2itzA-3nyoA:
19.9		 2itzA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 LEU A 261
LEU A 265
MET A 266
 None
AMP  A 577 ( 4.9A)
None
 0.44A 2itzA-3nyoA:
19.9		 2itzA-3nyoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
LYS A 215
GLU A 234
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.49A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
VAL A 200
LYS A 215
LEU A 238
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.45A 2ivuA-3nyoA:
25.8		 2ivuA-3nyoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 TRP A 368
TRP A 369
ARG A 431
LEU A 423
 None
 1.46A 2j2pD-3nyoA:
undetectable
2j2pF-3nyoA:
undetectable		 2j2pD-3nyoA:
16.03
2j2pF-3nyoA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 LEU A 371
ILE A 317
GLY A 298
HIS A 303
 None
 0.94A 2otfA-3nyoA:
undetectable		 2otfA-3nyoA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 GLU A 406
GLN A 422
ARG A 435
 None
 0.99A 2w3bB-3nyoA:
undetectable		 2w3bB-3nyoA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
ASP A 329
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.0A)
 0.82A 2wgjA-3nyoA:
22.4		 2wgjA-3nyoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 2xp2A-3nyoA:
7.5		 2xp2A-3nyoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.32A 2y7jA-3nyoA:
29.9		 2y7jA-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.37A 2y7jB-3nyoA:
30.6		 2y7jB-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.36A 2y7jC-3nyoA:
27.3		 2y7jC-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 200
ALA A 213
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.41A 2y7jD-3nyoA:
30.2		 2y7jD-3nyoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
AMP  A 577 (-4.8A)
 0.55A 2zvaA-3nyoA:
19.0		 2zvaA-3nyoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 10 ALA A 213
VAL A 247
LEU A 263
LEU A 265
MET A 266
GLY A 268
LEU A 318
 AMP  A 577 (-3.4A)
None
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 1.11A 3aoxA-3nyoA:
22.1		 3aoxA-3nyoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 10 ARG A 190
LEU A 192
ALA A 213
LYS A 215
LEU A 263
GLY A 269
LEU A 318
 None
AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
None
AMP  A 577 (-4.8A)
 1.18A 3aoxA-3nyoA:
22.1		 3aoxA-3nyoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 10 LEU A 192
ALA A 213
LYS A 215
VAL A 247
LEU A 263
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.60A 3aoxA-3nyoA:
22.1		 3aoxA-3nyoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 6 PRO A 354
GLY A 350
MET A 352
TRP A 369
 None
 1.40A 3aqiA-3nyoA:
undetectable		 3aqiA-3nyoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 6 PRO A 354
GLY A 350
MET A 352
TRP A 369
 None
 1.42A 3aqiB-3nyoA:
undetectable		 3aqiB-3nyoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
ALA A 213
LYS A 215
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.73A 3c7qA-3nyoA:
20.7		 3c7qA-3nyoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 11 LEU A 192
VAL A 200
ALA A 213
GLY A 269
ASP A 270
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.68A 3g0fA-3nyoA:
21.4		 3g0fA-3nyoA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
 0.56A 3g5dA-3nyoA:
23.1		 3g5dA-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.60A 3g5dB-3nyoA:
18.0		 3g5dB-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 7 VAL A 246
LEU A 261
LEU A 265
MET A 266
ILE A 327
 None
None
AMP  A 577 ( 4.9A)
None
None
 0.75A 3gp0A-3nyoA:
23.6		 3gp0A-3nyoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 ALA A 213
LYS A 215
GLU A 234
LEU A 238
LEU A 265
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
 0.54A 3hecA-3nyoA:
22.4		 3hecA-3nyoA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 4 LEU A 261
MET A 266
ILE A 307
ASP A 311
 None
 1.09A 3hecA-3nyoA:
22.6		 3hecA-3nyoA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.65A 3k54A-3nyoA:
22.1		 3k54A-3nyoA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 8 GLY A 193
MET A 278
PHE A 283
GLY A 269
 AMP  A 577 ( 3.7A)
None
None
None
 0.77A 3ko0O-3nyoA:
2.4
3ko0Q-3nyoA:
3.1		 3ko0O-3nyoA:
13.49
3ko0Q-3nyoA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 7 GLY A 269
GLY A 193
MET A 278
PHE A 283
 None
AMP  A 577 ( 3.7A)
None
None
 0.72A 3ko0M-3nyoA:
2.5
3ko0P-3nyoA:
2.5		 3ko0M-3nyoA:
13.49
3ko0P-3nyoA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 8 ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
MET A 266
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
 0.73A 3lfaA-3nyoA:
22.7		 3lfaA-3nyoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 9 ALA A 213
LYS A 215
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.71A 3miyB-3nyoA:
22.2		 3miyB-3nyoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.67A 3octA-3nyoA:
21.8		 3octA-3nyoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.62A 3qlgA-3nyoA:
22.3		 3qlgA-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
 0.50A 3qlgB-3nyoA:
22.8		 3qlgB-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.72A 3ue4A-3nyoA:
24.3		 3ue4A-3nyoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 265
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
 0.74A 3ug2A-3nyoA:
22.9		 3ug2A-3nyoA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 GLY A 196
GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
ASP A 329
 None
None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.0A)
 1.25A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
LEU A 318
 None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.89A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		3 / 3 LEU A 263
MET A 266
ASP A 270
 AMP  A 577 ( 4.7A)
None
AMP  A 577 (-3.6A)
 0.56A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 LEU A 192
VAL A 200
ALA A 213
LEU A 238
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
 0.47A 3wzdA-3nyoA:
21.4		 3wzdA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 ILE A 237
VAL A 247
LEU A 318
ASP A 329
 None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 1.06A 3wzdA-3nyoA:
21.4		 3wzdA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 302
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
 0.64A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 8 VAL A 246
VAL A 247
ILE A 327
ASP A 329
 None
None
None
AMP  A 577 (-4.0A)
 0.55A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 8 VAL A 246
VAL A 247
LEU A 318
ILE A 327
 None
None
AMP  A 577 (-4.8A)
None
 0.64A 3wzeA-3nyoA:
21.4		 3wzeA-3nyoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 ALA A 213
LEU A 263
LEU A 265
MET A 266
GLY A 269
ASP A 270
LEU A 318
ASP A 329
 AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.61A 3zbfA-3nyoA:
23.8		 3zbfA-3nyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LEU A 263
LEU A 265
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.68A 3zbfA-3nyoA:
23.8		 3zbfA-3nyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.80A 4ag8A-3nyoA:
21.4		 4ag8A-3nyoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.76A 4agcA-3nyoA:
21.1		 4agcA-3nyoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 11 LEU A 192
ALA A 213
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.52A 4agdA-3nyoA:
20.9		 4agdA-3nyoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.68A 4anqA-3nyoA:
22.6		 4anqA-3nyoA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 9 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.75A 4ansA-3nyoA:
22.6		 4ansA-3nyoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 302
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
 0.65A 4asdA-3nyoA:
21.2		 4asdA-3nyoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 11 LEU A 192
GLY A 193
GLY A 195
VAL A 200
ALA A 213
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-3.4A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.75A 4ckiA-3nyoA:
26.0		 4ckiA-3nyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.49A 4hjoA-3nyoA:
18.2		 4hjoA-3nyoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		9 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
LEU A 261
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.73A 4i22A-3nyoA:
21.0		 4i22A-3nyoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 200
ALA A 213
ASP A 270
ASP A 311
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 4i41A-3nyoA:
27.6		 4i41A-3nyoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 11 VAL A 200
ALA A 213
LEU A 263
ASP A 270
GLU A 315
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 (-3.6A)
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 1.00A 4iaaA-3nyoA:
27.6		 4iaaA-3nyoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 11 VAL A 200
ALA A 213
LYS A 215
LEU A 263
ASP A 270
GLU A 315
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
AMP  A 577 (-3.6A)
None
AMP  A 577 (-4.0A)
 0.93A 4iaaA-3nyoA:
27.6		 4iaaA-3nyoA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 249
LEU A 261
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.49A 4ifgA-3nyoA:
22.5		 4ifgA-3nyoA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 7 VAL A 200
ALA A 213
LEU A 217
MET A 266
ASP A 270
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.99A 4l9iA-3nyoA:
40.4		 4l9iA-3nyoA:
44.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 312
LEU A 299
ILE A 295
GLY A 372
LEU A 374
MET A 378
 None
 1.44A 4lmnA-3nyoA:
24.7		 4lmnA-3nyoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		11 / 12 LEU A 192
GLY A 195
VAL A 200
ALA A 213
LYS A 215
LEU A 263
LEU A 265
GLY A 269
ASP A 270
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.60A 4mkcA-3nyoA:
23.2		 4mkcA-3nyoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.87A 4mxoB-3nyoA:
23.5		 4mxoB-3nyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.88A 4mxxA-3nyoA:
17.9		 4mxxA-3nyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.82A 4mxxB-3nyoA:
21.6		 4mxxB-3nyoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.76A 4mxyA-3nyoA:
20.4		 4mxyA-3nyoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.81A 4mxyA-3nyoA:
20.4		 4mxyA-3nyoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.76A 4mxzA-3nyoA:
20.4		 4mxzA-3nyoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.81A 4mxzA-3nyoA:
20.4		 4mxzA-3nyoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 LEU A 171
LEU A  66
LEU A  49
ASN A 525
 None
 1.07A 4n09B-3nyoA:
undetectable		 4n09B-3nyoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 8 VAL A 200
ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 4ogrA-3nyoA:
28.3		 4ogrA-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 7 ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.53A 4ogrE-3nyoA:
27.4		 4ogrE-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 VAL A 200
ALA A 213
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 4ogrI-3nyoA:
28.1		 4ogrI-3nyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
GLY A 198
VAL A 200
ALA A 213
VAL A 247
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.59A 4otiA-3nyoA:
32.0		 4otiA-3nyoA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
LYS A 215
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.86A 4otwA-3nyoA:
20.5		 4otwA-3nyoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 GLU A 377
PRO A 384
ILE A 325
TYR A 376
TYR A 351
 None
 1.37A 4rfqA-3nyoA:
0.0		 4rfqA-3nyoA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.68A 4twpA-3nyoA:
24.1		 4twpA-3nyoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 4twpB-3nyoA:
24.5		 4twpB-3nyoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 11 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.50A 4u5jA-3nyoA:
18.2		 4u5jA-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.36A 4u5jB-3nyoA:
23.6		 4u5jB-3nyoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
LYS A 215
ARG A 310
LEU A 318
ILE A 327
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
AMP  A 577 (-4.8A)
None
 0.83A 4v01B-3nyoA:
21.5		 4v01B-3nyoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 11 LEU A 192
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
 0.65A 4wa9A-3nyoA:
20.8		 4wa9A-3nyoA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 8 LEU A 192
ALA A 213
ASN A 267
LEU A 318
SER A 328
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
None
 0.53A 4wboB-3nyoA:
40.2		 4wboB-3nyoA:
44.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 6 LEU A 192
ALA A 213
MET A 266
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.54A 4wboC-3nyoA:
39.7		 4wboC-3nyoA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.54A 4wkqA-3nyoA:
24.4		 4wkqA-3nyoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.66A 4xeyA-3nyoA:
23.9		 4xeyA-3nyoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
GLU A 234
VAL A 247
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
None
None
AMP  A 577 (-4.8A)
 0.55A 4xliA-3nyoA:
24.8		 4xliA-3nyoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.60A 4xliB-3nyoA:
24.9		 4xliB-3nyoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 6 ALA A 213
LEU A 265
MET A 266
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.38A 4xoyA-3nyoA:
26.8		 4xoyA-3nyoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 6 ALA A 213
LEU A 265
MET A 266
LEU A 318
 AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.39A 4xp3A-3nyoA:
27.5		 4xp3A-3nyoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.62A 5aaaA-3nyoA:
23.0		 5aaaA-3nyoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 10 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.60A 5aabA-3nyoA:
22.7		 5aabA-3nyoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 10 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 263
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
 0.68A 5aabA-3nyoA:
22.7		 5aabA-3nyoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 10 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 5aacA-3nyoA:
22.6		 5aacA-3nyoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 10 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 263
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
AMP  A 577 ( 4.7A)
None
None
AMP  A 577 (-4.8A)
 0.70A 5aacA-3nyoA:
22.6		 5aacA-3nyoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.53A 5h2uA-3nyoA:
21.5		 5h2uA-3nyoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.55A 5h2uB-3nyoA:
18.3		 5h2uB-3nyoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.50A 5h2uD-3nyoA:
18.3		 5h2uD-3nyoA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 7 GLY A 193
VAL A 200
LYS A 215
LEU A 217
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
 0.44A 5izjA-3nyoA:
36.3		 5izjA-3nyoA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 LEU A  56
TYR A  53
LEU A 162
TYR A 161
 None
 1.34A 5ki6A-3nyoA:
undetectable		 5ki6A-3nyoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 7 HIS A 303
HIS A 335
ILE A 307
VAL A 334
 None
 1.23A 5kkzC-3nyoA:
undetectable
5kkzE-3nyoA:
undetectable		 5kkzC-3nyoA:
16.20
5kkzE-3nyoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 GLY A 193
VAL A 200
ALA A 213
VAL A 247
ASP A 270
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
 0.58A 5l2iA-3nyoA:
7.8		 5l2iA-3nyoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 11 GLY A 193
VAL A 200
ALA A 213
VAL A 247
LEU A 263
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 ( 4.7A)
AMP  A 577 (-4.8A)
 0.58A 5lvnA-3nyoA:
34.5		 5lvnA-3nyoA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 11 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 263
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 (-4.8A)
 0.58A 5lvnA-3nyoA:
34.5		 5lvnA-3nyoA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 10 GLY A 193
VAL A 200
ALA A 213
LEU A 265
MET A 266
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
 0.43A 5lw1E-3nyoA:
24.4		 5lw1E-3nyoA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 9 GLY A 193
VAL A 200
ALA A 213
LEU A 265
MET A 266
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
 0.39A 5lw1H-3nyoA:
24.7		 5lw1H-3nyoA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 263
GLY A 269
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.7A)
None
 0.49A 5mafA-3nyoA:
29.1		 5mafA-3nyoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 1.18A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
VAL A 247
LEU A 261
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 0.82A 5vcvA-3nyoA:
24.6		 5vcvA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
 0.79A 5vcyA-3nyoA:
24.4		 5vcyA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 4 VAL A 247
LEU A 265
ASN A 316
ASP A 329
 None
AMP  A 577 ( 4.9A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.0A)
 0.85A 5vcyA-3nyoA:
24.4		 5vcyA-3nyoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 GLY A 459
GLY A 298
GLY A 457
ASP A 367
ILE A 327
 None
 0.98A 5wz1F-3nyoA:
undetectable		 5wz1F-3nyoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 GLY A 459
GLY A 298
GLY A 457
ASP A 367
ILE A 327
 None
 1.02A 5wz1H-3nyoA:
undetectable		 5wz1H-3nyoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
 0.83A 5y7zA-3nyoA:
24.7		 5y7zA-3nyoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
 0.83A 5y7zA-3nyoA:
24.7		 5y7zA-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
GLU A 234
LEU A 261
LEU A 265
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.83A 5y7zB-3nyoA:
24.7		 5y7zB-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
GLY A 269
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.0A)
 0.91A 5y7zB-3nyoA:
24.7		 5y7zB-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.0A)
 0.88A 5y80A-3nyoA:
23.9		 5y80A-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 (-4.8A)
 0.78A 5yu9A-3nyoA:
20.8		 5yu9A-3nyoA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 GLY A 193
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 (-4.8A)
 0.81A 5yu9B-3nyoA:
21.1		 5yu9B-3nyoA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
 0.71A 5zv2B-3nyoA:
21.5		 5zv2B-3nyoA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		5 / 12 LEU A  12
ILE A 472
LEU A 249
GLY A 268
LEU A 192
 None
None
None
None
AMP  A 577 ( 4.3A)
 0.96A 6a7pA-3nyoA:
2.3		 6a7pA-3nyoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 200
ALA A 213
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.73A 6bsdA-3nyoA:
20.8		 6bsdA-3nyoA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 200
ALA A 213
GLU A 234
MET A 266
GLY A 269
LEU A 318
SER A 328
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
None
 0.79A 6fnmA-3nyoA:
22.8		 6fnmA-3nyoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 200
ALA A 213
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.79A 6fnmA-3nyoA:
22.8		 6fnmA-3nyoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens) 		4 / 5 LEU A 192
ILE A 237
MET A 266
GLY A 269
 AMP  A 577 ( 4.3A)
None
None
None
 0.79A 6hd6A-3nyoA:
16.1		 6hd6A-3nyoA:
8.33