SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 193
LEU A 191
ALA A  67
VAL A 188
LEU A 160
 None
None
None
MCA  A 486 ( 4.1A)
None
 0.95A 1kt7A-3nyqA:
undetectable		 1kt7A-3nyqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 ARG A 200
LEU A 191
PHE A   5
LEU A 139
LEU A 167
 None
 1.12A 1og5A-3nyqA:
undetectable		 1og5A-3nyqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 310
LEU A 167
ILE A 281
LEU A 256
ARG A 255
 None
 1.15A 1qzfC-3nyqA:
undetectable		 1qzfC-3nyqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 310
LEU A 167
ILE A 281
LEU A 256
ARG A 255
 None
 1.14A 1qzfE-3nyqA:
undetectable		 1qzfE-3nyqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 5 LEU A 164
LEU A   4
LEU A   8
LEU A 160
 None
 0.99A 1yajD-3nyqA:
undetectable		 1yajD-3nyqA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 192
LEU A 196
LEU A 290
PHE A   5
ALA A 138
 None
 1.07A 2aylA-3nyqA:
undetectable		 2aylA-3nyqA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 11 ALA A 138
LEU A 160
ALA A 159
LEU A 191
VAL A 192
 None
 0.99A 2bxeB-3nyqA:
undetectable		 2bxeB-3nyqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 8 ALA A 138
ALA A 159
LEU A 191
VAL A 192
 None
 0.79A 2bxgA-3nyqA:
undetectable		 2bxgA-3nyqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 10 ALA A 138
LEU A 160
ALA A 159
LEU A 191
VAL A 192
 None
 0.98A 2bxgB-3nyqA:
undetectable		 2bxgB-3nyqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 209
LEU A 183
SER A 212
GLY A 215
GLU A 219
 None
MCA  A 486 ( 4.3A)
None
None
None
 1.04A 3g2oB-3nyqA:
undetectable		 3g2oB-3nyqA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 VAL A 280
LEU A 257
LEU A 264
GLY A 277
ALA A 273
 None
 1.29A 3pghA-3nyqA:
undetectable		 3pghA-3nyqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 160
LEU A 167
ILE A 155
SER A 294
THR A 293
 None
 1.07A 4f4dB-3nyqA:
undetectable		 4f4dB-3nyqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 HIS A 187
ALA A 455
ILE A 389
GLU A  86
GLY A 145
 MCA  A 486 ( 4.2A)
CL  A 498 ( 3.7A)
None
None
None
 1.12A 4hfpB-3nyqA:
undetectable		 4hfpB-3nyqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 6 PHE A 228
GLY A 229
ILE A 237
LEU A 220
 None
 0.77A 4o8fB-3nyqA:
undetectable		 4o8fB-3nyqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 VAL A  53
LEU A 100
LEU A  70
VAL A  63
LEU A 191
 None
 1.02A 4otyA-3nyqA:
undetectable		 4otyA-3nyqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 7 LEU A 139
LEU A 160
ARG A 200
LEU A 196
 None
 0.78A 4wg0B-3nyqA:
undetectable
4wg0C-3nyqA:
undetectable		 4wg0B-3nyqA:
2.18
4wg0C-3nyqA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 7 LEU A 160
ARG A 200
LEU A 196
LEU A 139
 None
 0.75A 4wg0L-3nyqA:
undetectable
4wg0M-3nyqA:
undetectable		 4wg0L-3nyqA:
2.18
4wg0M-3nyqA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 THR A 293
THR A 366
GLY A 340
PRO A 341
ALA A 159
 None
 1.11A 4ypmA-3nyqA:
undetectable		 4ypmA-3nyqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 285
MET A 286
PHE A  24
GLY A  62
LEU A 196
 MCA  A 486 ( 3.7A)
AMP  A 487 ( 3.8A)
CL  A 497 (-4.7A)
None
None
 1.29A 4ze1A-3nyqA:
undetectable		 4ze1A-3nyqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 376
THR A 293
ASP A 375
ARG A 302
LEU A 328
 None
 1.02A 5bw4A-3nyqA:
undetectable		 5bw4A-3nyqA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		3 / 3 TRP A 171
ARG A 283
LEU A 179
 None
MCA  A 486 ( 3.0A)
None
 0.85A 5dbyA-3nyqA:
undetectable		 5dbyA-3nyqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 GLY A  83
SER A  82
ASP A  84
GLY A 148
HIS A  89
 None
 1.25A 5hikA-3nyqA:
undetectable		 5hikA-3nyqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 GLY A  62
VAL A  53
LEU A  34
VAL A  66
LEU A   8
 None
 1.18A 5ubbA-3nyqA:
2.8		 5ubbA-3nyqA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 ILE A 389
ASP A 421
LEU A 424
GLY A 425
VAL A 462
 None
 1.14A 5x66F-3nyqA:
undetectable		 5x66F-3nyqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 ILE A 396
ASP A 421
LEU A 424
GLY A 425
VAL A 462
 None
 1.12A 5x66F-3nyqA:
undetectable		 5x66F-3nyqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 4 PHE A 228
LEU A 160
LEU A 167
VAL A 188
 None
None
None
MCA  A 486 ( 4.1A)
 0.96A 5xxiA-3nyqA:
undetectable		 5xxiA-3nyqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 6 SER A 259
ARG A 302
ARG A 279
ASP A 375
 None
 1.22A 5zw4A-3nyqA:
undetectable		 5zw4A-3nyqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_A_NCTA501_1
(AMINE OXIDASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 241
GLU A 246
THR A 276
ALA A 217
ASN A 221
 None
 1.40A 6c71A-3nyqA:
0.0		 6c71A-3nyqA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		5 / 12 ARG A  23
GLY A 215
ALA A 216
LEU A 257
VAL A 180
 None
 1.06A 6dh0B-3nyqA:
undetectable		 6dh0B-3nyqA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3nyq MALONYL-COA LIGASE
(Streptomyces
coelicolor) 		4 / 6 ARG A 271
ALA A 238
LEU A 241
ALA A 275
 None
 1.23A 6fosB-3nyqA:
undetectable		 6fosB-3nyqA:
10.88