SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.22A 1t69A-3nyyA:
undetectable		 1t69A-3nyyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 ILE A 157
THR A 155
LEU A 265
VAL A 169
LEU A 205
 None
 1.22A 2jn3A-3nyyA:
undetectable		 2jn3A-3nyyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		4 / 5 HIS A 243
HIS A 204
ASP A 156
HIS A 245
 None
 1.01A 3c0zA-3nyyA:
undetectable		 3c0zA-3nyyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		4 / 6 HIS A 243
HIS A 204
ASP A 156
HIS A 245
 None
 1.02A 3c0zC-3nyyA:
undetectable		 3c0zC-3nyyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.25A 4bz6C-3nyyA:
undetectable		 4bz6C-3nyyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.20A 4lxzA-3nyyA:
undetectable		 4lxzA-3nyyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.18A 4lxzC-3nyyA:
undetectable		 4lxzC-3nyyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		4 / 6 ASN A 162
ALA A 159
TYR A 167
ASP A 206
 2PE  A 282 ( 3.9A)
None
None
None
 1.19A 4mdbA-3nyyA:
undetectable		 4mdbA-3nyyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.30A 4qa0A-3nyyA:
undetectable		 4qa0A-3nyyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.22A 4qa2A-3nyyA:
undetectable		 4qa2A-3nyyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.25A 4qa2B-3nyyA:
undetectable		 4qa2B-3nyyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 11 LEU A 250
GLY A 247
LEU A 246
ALA A 194
ASP A 117
 None
 1.36A 4wnuC-3nyyA:
undetectable		 4wnuC-3nyyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 LYS A 251
LEU A 250
ALA A 113
ALA A 194
ILE A 114
 2PE  A 281 (-2.9A)
None
None
None
None
 1.04A 4x1iD-3nyyA:
undetectable		 4x1iD-3nyyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		3 / 3 ARG A 112
ASP A  63
TYR A  95
 SO4  A 284 (-2.6A)
None
SO4  A 284 (-4.6A)
 0.85A 4yo9B-3nyyA:
undetectable		 4yo9B-3nyyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		4 / 5 PHE A  45
ASP A  44
PHE A  77
VAL A  39
 None
 1.14A 5a1rA-3nyyA:
undetectable		 5a1rA-3nyyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.27A 5eeiA-3nyyA:
undetectable		 5eeiA-3nyyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		5 / 12 HIS A 243
HIS A 204
GLY A 186
ASP A 156
HIS A 245
 None
 1.26A 5eeiB-3nyyA:
undetectable		 5eeiB-3nyyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM
([Ruminococcus]
gnavus) 		3 / 3 VAL A 170
GLN A 125
CYH A 275
 None
 0.84A 5icxC-3nyyA:
undetectable
5icxF-3nyyA:
undetectable		 5icxC-3nyyA:
20.08
5icxF-3nyyA:
3.97