SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.79A 1a7yA-3nz4A:
undetectable		 1a7yA-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.74A 1a7yB-3nz4A:
undetectable		 1a7yB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.70A 1a7yB-3nz4A:
undetectable		 1a7yB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.79A 1fjaC-3nz4A:
undetectable		 1fjaC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.79A 1fjaD-3nz4A:
undetectable		 1fjaD-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 ILE A 185
TYR A 184
LEU A 109
LEU A 189
ILE A 190
 None
 1.10A 1fmlB-3nz4A:
undetectable		 1fmlB-3nz4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.79A 1i3wE-3nz4A:
undetectable		 1i3wE-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.77A 1i3wE-3nz4A:
undetectable		 1i3wE-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.78A 1i3wF-3nz4A:
undetectable		 1i3wF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.73A 1i3wG-3nz4A:
undetectable		 1i3wG-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.78A 1i3wG-3nz4A:
undetectable		 1i3wG-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.77A 1i3wH-3nz4A:
undetectable		 1i3wH-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 10 LEU A 529
ALA A 532
LEU A 528
LEU A 592
LEU A 588
 None
 1.35A 1ie4A-3nz4A:
undetectable
1ie4C-3nz4A:
undetectable		 1ie4A-3nz4A:
11.16
1ie4C-3nz4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.82A 1mnvD-3nz4A:
undetectable		 1mnvD-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.81A 1mnvD-3nz4A:
undetectable		 1mnvD-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 6 ASP A  30
GLY A  31
THR A  33
PRO A  34
 None
 0.74A 1n4fA-3nz4A:
undetectable		 1n4fA-3nz4A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 256
GLU A 263
ASP A 303
 None
 0.62A 1nt2A-3nz4A:
undetectable		 1nt2A-3nz4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.86A 1ovfB-3nz4A:
undetectable		 1ovfB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.81A 1qfiA-3nz4A:
undetectable		 1qfiA-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.74A 1qfiB-3nz4A:
undetectable		 1qfiB-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.71A 1unjF-3nz4A:
undetectable		 1unjF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.76A 1unjF-3nz4A:
undetectable		 1unjF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.73A 1unjL-3nz4A:
undetectable		 1unjL-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.76A 1unjL-3nz4A:
undetectable		 1unjL-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.78A 1unjR-3nz4A:
undetectable		 1unjR-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.75A 1unjR-3nz4A:
undetectable		 1unjR-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.79A 1unjW-3nz4A:
undetectable		 1unjW-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.73A 1unjX-3nz4A:
undetectable		 1unjX-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.76A 1unjX-3nz4A:
undetectable		 1unjX-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.76A 1unmE-3nz4A:
undetectable		 1unmE-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.77A 1unmE-3nz4A:
undetectable		 1unmE-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.76A 1unmF-3nz4A:
undetectable		 1unmF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.73A 1unmF-3nz4A:
undetectable		 1unmF-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 5 GLU A 404
TYR A 405
SER A 415
ASP A 430
 None
 1.49A 1vidA-3nz4A:
undetectable		 1vidA-3nz4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.72A 209dC-3nz4A:
undetectable		 209dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 127
THR A 129
PRO A 125
 None
 0.70A 209dC-3nz4A:
undetectable		 209dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 SER A 172
LYS A 178
SER A 463
VAL A 173
 MDO  A 176 ( 3.7A)
MDO  A 176 ( 3.3A)
MDO  A 176 ( 4.8A)
MDO  A 176 ( 4.6A)
 1.23A 2j9cA-3nz4A:
undetectable
2j9cB-3nz4A:
undetectable
2j9cC-3nz4A:
undetectable		 2j9cA-3nz4A:
9.90
2j9cB-3nz4A:
9.90
2j9cC-3nz4A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 GLY A 678
ILE A  14
ASP A  13
LEU A 673
LEU A 669
 None
 0.92A 2nxeA-3nz4A:
undetectable		 2nxeA-3nz4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 539
ASP A 312
SER A 310
 None
 0.71A 2nxeA-3nz4A:
undetectable		 2nxeA-3nz4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 539
ASP A 312
SER A 310
 None
 0.74A 2nxeB-3nz4A:
undetectable		 2nxeB-3nz4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 ASN A 248
LEU A 252
HIS A  10
 None
 0.65A 2q6fB-3nz4A:
undetectable		 2q6fB-3nz4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 VAL A 383
ALA A 341
PRO A 446
THR A 448
 None
 0.98A 2q6oA-3nz4A:
undetectable		 2q6oA-3nz4A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 VAL A 167
PRO A 168
VAL A 195
SER A 194
 None
 0.96A 2v32C-3nz4A:
undetectable
2v32D-3nz4A:
undetectable		 2v32C-3nz4A:
15.31
2v32D-3nz4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 11 THR A 141
VAL A  29
ASN A 138
VAL A 349
ASN A 350
 None
 1.46A 2w4xA-3nz4A:
undetectable		 2w4xA-3nz4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 THR A 141
VAL A  29
ASN A 138
VAL A 349
ASN A 350
 None
 1.43A 2x0yA-3nz4A:
3.0		 2x0yA-3nz4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 9 ALA A 240
VAL A 376
GLY A 377
LEU A 466
ALA A 236
 None
 0.98A 2z0yA-3nz4A:
undetectable		 2z0yA-3nz4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 9 ALA A 240
VAL A 376
ILE A 467
LEU A 466
ALA A 236
 None
 0.97A 2z0yA-3nz4A:
undetectable		 2z0yA-3nz4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.78A 316dC-3nz4A:
undetectable		 316dC-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 LEU A 429
LEU A 426
ARG A 645
 None
 0.64A 3hcnB-3nz4A:
undetectable		 3hcnB-3nz4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 11 LEU A 416
LEU A 499
LEU A 541
GLY A 412
LEU A 414
 None
 1.24A 3hm1B-3nz4A:
undetectable		 3hm1B-3nz4A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 6 LEU A 331
GLU A 255
SER A 327
PHE A 271
 None
 1.31A 3i9jB-3nz4A:
undetectable		 3i9jB-3nz4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 9 LEU A 159
SER A 161
ALA A 197
ALA A 126
THR A 129
 None
 1.10A 3mdtA-3nz4A:
undetectable		 3mdtA-3nz4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 TYR A 245
ALA A 247
SER A 241
ASP A 473
LEU A 476
 None
 1.18A 3ou6C-3nz4A:
undetectable		 3ou6C-3nz4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 TYR A 245
ALA A 247
SER A 241
ASP A 473
LEU A 476
 None
 1.20A 3ou6D-3nz4A:
undetectable		 3ou6D-3nz4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 TYR A 245
ALA A 247
SER A 241
ASP A 473
LEU A 476
 None
 1.21A 3ou7A-3nz4A:
undetectable		 3ou7A-3nz4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 TYR A 245
ALA A 247
SER A 241
ASP A 473
LEU A 476
 None
 1.21A 3ou7D-3nz4A:
undetectable		 3ou7D-3nz4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 6 TYR A 245
VAL A  51
VAL A  24
ILE A  35
 None
 1.04A 3pyyA-3nz4A:
undetectable		 3pyyA-3nz4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 VAL A 230
LEU A 108
GLN A 101
LEU A 100
 None
 0.99A 3qeoB-3nz4A:
undetectable		 3qeoB-3nz4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 PHE A 395
ILE A 385
GLY A 391
SER A 437
ALA A 444
 None
 0.97A 3sufB-3nz4A:
undetectable		 3sufB-3nz4A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 TRP A 294
MET A 260
ARG A 624
PRO A 300
 None
 1.19A 3ucbB-3nz4A:
undetectable		 3ucbB-3nz4A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 LEU A 250
ILE A  18
GLY A 663
ILE A 660
ARG A  46
 None
 0.91A 3uj6A-3nz4A:
undetectable		 3uj6A-3nz4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 LEU A 250
ILE A  18
GLY A 663
ILE A 660
ARG A  46
 None
 0.91A 3uj7A-3nz4A:
undetectable		 3uj7A-3nz4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 LEU A 135
ASN A 353
ALA A 352
ARG A  61
THR A 237
 None
 1.45A 3vhuA-3nz4A:
undetectable		 3vhuA-3nz4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 ARG A 664
ASP A 652
GLN A 647
 None
 0.75A 4azsA-3nz4A:
undetectable		 4azsA-3nz4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 THR A 129
PRO A 125
THR A 127
 None
 0.83A 4hivD-3nz4A:
undetectable		 4hivD-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 10 ARG A 664
ILE A 483
ALA A 484
THR A 488
VAL A 632
 None
 1.25A 4kq8A-3nz4A:
undetectable		 4kq8A-3nz4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 ASP A 178
SER A 172
ALA A 465
SER A 463
 MDO  A 176 ( 4.3A)
MDO  A 176 ( 3.7A)
None
MDO  A 176 ( 4.8A)
 0.94A 4lv9A-3nz4A:
undetectable
4lv9B-3nz4A:
undetectable		 4lv9A-3nz4A:
21.39
4lv9B-3nz4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 7 ASP A 178
SER A 172
ALA A 465
SER A 463
 MDO  A 176 ( 4.3A)
MDO  A 176 ( 3.7A)
None
MDO  A 176 ( 4.8A)
 0.95A 4lv9A-3nz4A:
undetectable
4lv9B-3nz4A:
undetectable		 4lv9A-3nz4A:
21.39
4lv9B-3nz4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 GLU A 346
THR A  20
HIS A  39
 None
 0.84A 4q15A-3nz4A:
undetectable		 4q15A-3nz4A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		3 / 3 GLU A 346
THR A  20
HIS A  39
 None
 0.82A 4q15B-3nz4A:
undetectable		 4q15B-3nz4A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 12 THR A  20
THR A 342
ILE A  35
ASN A 350
HIS A  39
 None
 1.36A 4s0vA-3nz4A:
undetectable		 4s0vA-3nz4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 5 GLN A 302
ARG A 268
CYH A 262
GLU A 263
 None
 1.27A 5fseC-3nz4A:
undetectable		 5fseC-3nz4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 5 ALA A 186
ALA A 183
ILE A 105
LEU A 104
 None
None
None
TCA  A 699 (-4.8A)
 0.81A 5jncD-3nz4A:
undetectable		 5jncD-3nz4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 SER A 351
MET A 152
ASP A 354
SER A 145
 None
 1.13A 5l5fY-3nz4A:
undetectable
5l5fZ-3nz4A:
undetectable		 5l5fY-3nz4A:
14.56
5l5fZ-3nz4A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 LEU A 476
ALA A  41
VAL A 387
MET A 244
 None
 0.96A 5nu7A-3nz4A:
undetectable		 5nu7A-3nz4A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 5 ARG A 130
LEU A  43
ASN A 160
VAL A  51
 None
 1.33A 5os7B-3nz4A:
undetectable		 5os7B-3nz4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 8 ILE A 185
LEU A 188
LEU A 211
MET A 133
 None
 1.00A 5u4sB-3nz4A:
undetectable		 5u4sB-3nz4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 9 LEU A 331
GLY A 259
LEU A 292
VAL A 254
CYH A 258
 None
 1.34A 6czmD-3nz4A:
undetectable
6czmE-3nz4A:
undetectable		 6czmD-3nz4A:
21.68
6czmE-3nz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		5 / 10 LEU A 331
GLY A 259
LEU A 292
VAL A 254
CYH A 258
 None
 1.31A 6czmE-3nz4A:
undetectable
6czmF-3nz4A:
undetectable		 6czmE-3nz4A:
21.68
6czmF-3nz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3nz4 PHENYLALANINE
AMMONIA-LYASE
(Taxus
canadensis) 		4 / 5 ARG A 130
LEU A  43
ASN A 160
VAL A  51
 None
 1.33A 6gmdA-3nz4A:
undetectable		 6gmdA-3nz4A:
18.22