SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 11 VAL A 106
ILE A 207
ILE A 279
VAL A 123
PHE A 161
 None
 1.33A 1gx9A-3nzeA:
undetectable		 1gx9A-3nzeA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 279
LEU A 120
GLY A 209
VAL A 123
ALA A 122
 None
 1.10A 1tlsA-3nzeA:
undetectable		 1tlsA-3nzeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 284
SER A 286
ALA A 285
GLY A 293
ARG A 312
 None
 1.01A 2vmyA-3nzeA:
undetectable		 2vmyA-3nzeA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 247
ASP A 243
HIS A 269
THR A 301
GLY A 209
 None
 1.31A 3j6pB-3nzeA:
undetectable		 3j6pB-3nzeA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 11 ILE A 207
GLY A 209
VAL A 210
VAL A  94
ILE A 304
 None
 1.01A 3oxxD-3nzeA:
undetectable		 3oxxD-3nzeA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
 None
 1.13A 3uvvB-3nzeA:
undetectable		 3uvvB-3nzeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 162
GLY A 166
LEU A 127
VAL A 137
VAL A 114
 None
 1.01A 4htfB-3nzeA:
2.7		 4htfB-3nzeA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		4 / 6 ASP A 228
ASN A 145
ALA A 176
ASP A 231
 None
 1.14A 4mdbA-3nzeA:
undetectable		 4mdbA-3nzeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 247
ASP A 243
HIS A 269
THR A 301
GLY A 209
 None
 1.26A 5ogcB-3nzeA:
undetectable		 5ogcB-3nzeA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		4 / 5 THR A 185
GLU A 262
THR A 259
HIS A 230
 None
 1.22A 5utuH-3nzeA:
3.7		 5utuH-3nzeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 10 VAL A 210
GLY A 211
ALA A 294
LEU A 291
ASN A 289
 None
 1.08A 5x6yB-3nzeA:
undetectable		 5x6yB-3nzeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
 None
 0.94A 6a5zD-3nzeA:
undetectable		 6a5zD-3nzeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
 None
 0.92A 6a5zL-3nzeA:
undetectable		 6a5zL-3nzeA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY
(Paenarthrobacter
aurescens) 		5 / 12 ILE A 279
ALA A  98
GLN A  97
ILE A 112
LEU A 120
 None
 1.02A 6a60D-3nzeA:
undetectable		 6a60D-3nzeA:
15.41