SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 PRO A 506
VAL A 507
VAL A 565
ILE A 376
GLY A 561
 None
 1.30A 13gsA-3nzqA:
undetectable		 13gsA-3nzqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 9 PRO A 506
VAL A 507
VAL A 565
ILE A 376
GLY A 561
 None
 1.30A 13gsB-3nzqA:
undetectable		 13gsB-3nzqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 SER A 236
SER A 235
GLY A 244
GLU A 239
GLY A 231
 None
 1.27A 1mehA-3nzqA:
8.6		 1mehA-3nzqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ASP A 464
ASN A 467
ARG A 414
ALA A 469
 None
 1.17A 1rqpA-3nzqA:
undetectable		 1rqpA-3nzqA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 107
TYR A 120
VAL A 309
GLY A 310
 None
 0.91A 1t88A-3nzqA:
undetectable		 1t88A-3nzqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A 107
TYR A 120
VAL A 309
GLY A 310
 None
 0.90A 2a1mA-3nzqA:
undetectable		 2a1mA-3nzqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 PHE A 107
TYR A 120
VAL A 309
GLY A 310
 None
 0.87A 2a1oA-3nzqA:
undetectable		 2a1oA-3nzqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLN A 460
LEU A 477
LEU A 463
SER A 416
LEU A 417
 None
 1.39A 2ceoB-3nzqA:
undetectable		 2ceoB-3nzqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 PHE A  92
VAL A  76
VAL A 585
VAL A 597
 None
 0.91A 2qbnA-3nzqA:
undetectable		 2qbnA-3nzqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ILE A 339
PHE A 271
GLY A 312
GLY A 311
 None
None
SO4  A 701 (-4.2A)
SO4  A 701 ( 3.8A)
 0.84A 2qx6A-3nzqA:
undetectable
2qx6B-3nzqA:
undetectable		 2qx6A-3nzqA:
15.90
2qx6B-3nzqA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 HIS A  98
SER A 102
ASP A  64
ALA A 105
 None
 1.33A 2rk8A-3nzqA:
2.4		 2rk8A-3nzqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 310
ILE A 358
LEU A 313
ALA A 364
VAL A 123
 None
 1.00A 2yqzA-3nzqA:
undetectable		 2yqzA-3nzqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 HIS A 270
LEU A 147
VAL A 128
ILE A 169
GLU A 360
 None
 1.10A 2yy8A-3nzqA:
2.0
2yy8B-3nzqA:
4.3		 2yy8A-3nzqA:
16.07
2yy8B-3nzqA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 THR A 366
VAL A 134
ILE A 126
GLU A 154
GLN A 130
 None
 1.24A 2yzqA-3nzqA:
undetectable		 2yzqA-3nzqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 THR A 366
VAL A 134
ILE A 135
ILE A 126
GLN A 130
 None
 1.30A 2yzqA-3nzqA:
undetectable		 2yzqA-3nzqA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 LEU A  89
GLN A 493
THR A 582
HIS A 369
 None
 1.35A 2zj0C-3nzqA:
undetectable		 2zj0C-3nzqA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 362
ALA A 367
ALA A 567
ILE A 103
 SO4  A 701 (-3.5A)
None
None
None
 0.75A 3a2qA-3nzqA:
undetectable		 3a2qA-3nzqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 ASP A 308
ILE A 103
ILE A 358
GLY A 310
 None
 0.87A 3bufA-3nzqA:
undetectable		 3bufA-3nzqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 LEU A  89
GLN A 493
THR A 582
HIS A 369
 None
 1.35A 3ce6B-3nzqA:
undetectable		 3ce6B-3nzqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		6 / 12 ARG A 133
ASP A  71
VAL A  59
ILE A  57
GLY A 561
LEU A 372
 None
 1.14A 3em6B-3nzqA:
undetectable		 3em6B-3nzqA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 VAL A 565
THR A 370
GLU A 583
SER A 600
ARG A 133
 None
 1.43A 3kp5A-3nzqA:
undetectable		 3kp5A-3nzqA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 296
GLU A 349
ASN A 350
 None
 0.75A 3lp9B-3nzqA:
undetectable
3lp9D-3nzqA:
undetectable		 3lp9B-3nzqA:
14.89
3lp9D-3nzqA:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N2O_A_AG2A1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		6 / 9 LYS A 127
HIS A 272
GLY A 274
SER A 275
ASP A 497
LEU A 572
 None
None
None
SO4  A 701 (-2.6A)
None
None
 0.98A 3n2oA-3nzqA:
43.2
3n2oB-3nzqA:
43.4		 3n2oA-3nzqA:
53.68
3n2oB-3nzqA:
53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		6 / 9 LYS A 127
HIS A 272
GLY A 274
SER A 275
TYR A 568
LEU A 572
 None
None
None
SO4  A 701 (-2.6A)
SO4  A 701 (-4.8A)
None
 0.94A 3n2oA-3nzqA:
43.2
3n2oB-3nzqA:
43.4		 3n2oA-3nzqA:
53.68
3n2oB-3nzqA:
53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 LYS A 127
HIS A 272
SER A 275
ASP A 497
 None
None
SO4  A 701 (-2.6A)
None
 0.78A 3n2oC-3nzqA:
43.3
3n2oD-3nzqA:
43.3		 3n2oC-3nzqA:
53.68
3n2oD-3nzqA:
53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 LYS A 127
HIS A 272
SER A 275
LEU A 572
 None
None
SO4  A 701 (-2.6A)
None
 0.98A 3n2oC-3nzqA:
43.3
3n2oD-3nzqA:
43.3		 3n2oC-3nzqA:
53.68
3n2oD-3nzqA:
53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		7 / 10 LYS A 127
HIS A 272
GLY A 274
ARG A 363
ASP A 497
TYR A 568
LEU A 572
 None
None
None
SO4  A 701 (-4.5A)
None
SO4  A 701 (-4.8A)
None
 0.84A 3n2oC-3nzqA:
43.3
3n2oD-3nzqA:
43.3		 3n2oC-3nzqA:
53.68
3n2oD-3nzqA:
53.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 LEU A  89
GLN A 493
THR A 582
HIS A 369
 None
 1.31A 3n58C-3nzqA:
2.7		 3n58C-3nzqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 PRO A 125
ASN A 104
ILE A 126
GLU A 360
ILE A 358
 None
 1.46A 3q5pA-3nzqA:
undetectable		 3q5pA-3nzqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 TYR A  49
PHE A 563
VAL A 585
VAL A  76
PHE A  92
 None
 1.41A 3u9fB-3nzqA:
undetectable
3u9fC-3nzqA:
undetectable		 3u9fB-3nzqA:
14.41
3u9fC-3nzqA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 PHE A  92
TYR A  49
PHE A 563
VAL A 585
VAL A  76
 None
 1.41A 3u9fD-3nzqA:
0.0
3u9fF-3nzqA:
0.0		 3u9fD-3nzqA:
14.41
3u9fF-3nzqA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 PHE A  92
TYR A  49
PHE A 563
VAL A 585
VAL A  76
 None
 1.38A 3u9fM-3nzqA:
undetectable
3u9fO-3nzqA:
undetectable		 3u9fM-3nzqA:
14.41
3u9fO-3nzqA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ASP A 483
VAL A 487
ASN A 556
PRO A 558
LEU A 560
 None
 1.25A 3v8vB-3nzqA:
2.5		 3v8vB-3nzqA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 4 PRO A 217
LEU A 184
ILE A 180
ARG A 177
 None
 0.97A 3w1wA-3nzqA:
undetectable		 3w1wA-3nzqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 GLY A 362
THR A 366
ILE A 135
VAL A 134
 SO4  A 701 (-3.5A)
None
None
None
 0.66A 3wriA-3nzqA:
undetectable		 3wriA-3nzqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 GLY A 362
THR A 366
ILE A 135
VAL A 134
 SO4  A 701 (-3.5A)
None
None
None
 0.66A 3wriB-3nzqA:
undetectable		 3wriB-3nzqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 346
ILE A 340
ILE A 339
VAL A 287
ILE A 283
 None
 0.97A 4ax8A-3nzqA:
2.4		 4ax8A-3nzqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ALA A 346
ILE A 340
ILE A 339
VAL A 287
ILE A 283
 None
 0.97A 4azvA-3nzqA:
2.9		 4azvA-3nzqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLU A 360
GLY A 146
TYR A 568
SER A 275
HIS A 272
 None
None
SO4  A 701 (-4.8A)
SO4  A 701 (-2.6A)
None
 1.46A 4ffwB-3nzqA:
2.9		 4ffwB-3nzqA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 5 GLY A 311
GLY A 312
MET A 277
GLU A 360
 SO4  A 701 ( 3.8A)
SO4  A 701 (-4.2A)
None
None
 1.22A 4fglC-3nzqA:
undetectable		 4fglC-3nzqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLY A 312
GLU A 360
THR A 359
 SO4  A 701 (-4.2A)
None
None
 0.59A 4kouA-3nzqA:
undetectable		 4kouA-3nzqA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 TYR A 116
ALA A 291
TYR A 294
VAL A 295
GLY A 344
 None
 1.18A 4mm4B-3nzqA:
undetectable		 4mm4B-3nzqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ILE A 185
ALA A 183
LEU A 213
ALA A 210
LEU A 159
 None
 1.15A 4nqaA-3nzqA:
undetectable		 4nqaA-3nzqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 344
PHE A 307
ILE A 339
PHE A 271
 None
 1.02A 4qogA-3nzqA:
undetectable
4qogB-3nzqA:
undetectable		 4qogA-3nzqA:
15.77
4qogB-3nzqA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ILE A 358
LEU A 147
ILE A 135
PHE A 121
 None
 0.77A 4r38A-3nzqA:
undetectable		 4r38A-3nzqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		5 / 9 ILE A 358
VAL A 158
LEU A 147
ILE A 135
PHE A 121
 None
 1.22A 4r38C-3nzqA:
undetectable		 4r38C-3nzqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 GLY A 310
SER A 361
SER A 275
HIS A 272
 None
None
SO4  A 701 (-2.6A)
None
 1.01A 4ws1A-3nzqA:
undetectable		 4ws1A-3nzqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 TYR A 120
TYR A 335
GLY A 311
LEU A 122
 None
None
SO4  A 701 ( 3.8A)
None
 1.16A 5bphB-3nzqA:
undetectable		 5bphB-3nzqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 TYR A 120
TYR A 335
GLY A 311
SER A 361
 None
None
SO4  A 701 ( 3.8A)
None
 0.99A 5bphB-3nzqA:
undetectable		 5bphB-3nzqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 ALA A 105
ASN A 333
ARG A 109
HIS A  98
 None
 1.28A 5db5A-3nzqA:
undetectable
5db5B-3nzqA:
undetectable		 5db5A-3nzqA:
20.99
5db5B-3nzqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 LEU A 524
PHE A 489
ILE A 534
 None
 0.72A 5dzk1-3nzqA:
undetectable
5dzkF-3nzqA:
undetectable
5dzkM-3nzqA:
undetectable		 5dzk1-3nzqA:
0.74
5dzkF-3nzqA:
16.38
5dzkM-3nzqA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASN A 574
ASP A 531
GLY A 532
 None
 0.50A 5fctB-3nzqA:
undetectable		 5fctB-3nzqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 HIS A  98
GLU A 143
ALA A 364
LEU A 313
 None
 1.02A 5igiA-3nzqA:
undetectable		 5igiA-3nzqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ASP A  64
PRO A  63
TYR A  48
SER A 141
 None
 1.02A 5l1fC-3nzqA:
undetectable		 5l1fC-3nzqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 187
HIS A 191
VAL A 193
 None
 0.90A 5trqB-3nzqA:
undetectable		 5trqB-3nzqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLU A 596
ASP A 592
PRO A 591
 None
 0.65A 6berA-3nzqA:
undetectable		 6berA-3nzqA:
2.72