SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 7 LEU A  40
THR A 229
ASN A  15
TYR A 218
 None
 1.14A 1afsA-3nzrA:
5.3		 1afsA-3nzrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 7 LEU A  40
THR A 229
ASN A  15
TYR A 218
 None
 1.14A 1afsB-3nzrA:
5.6		 1afsB-3nzrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 7 TYR A  44
VAL A  21
VAL A  65
VAL A  37
 None
 0.83A 2qbnA-3nzrA:
undetectable		 2qbnA-3nzrA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		5 / 12 ALA A 205
ILE A 201
THR A 190
ILE A 217
ILE A 214
 None
 1.22A 3clbB-3nzrA:
undetectable		 3clbB-3nzrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		3 / 3 ASP A 233
ASP A 223
ASP A 194
 None
None
MG  A 247 (-2.6A)
 0.77A 3douA-3nzrA:
undetectable		 3douA-3nzrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 7 ILE A 221
LEU A 237
ALA A  30
ALA A  31
 None
 0.80A 3r9tB-3nzrA:
undetectable		 3r9tB-3nzrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 5 THR A 122
GLY A 124
VAL A 144
PRO A 143
 None
 1.16A 4grkA-3nzrA:
undetectable		 4grkA-3nzrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 8 ILE A 213
VAL A 234
LEU A 237
ILE A 221
 None
 0.69A 4r38A-3nzrA:
undetectable		 4r38A-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 8 LEU A  17
VAL A 234
LEU A 237
ILE A 221
 None
 0.81A 4r38A-3nzrA:
undetectable		 4r38A-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		6 / 9 THR A 190
ILE A 213
LEU A  17
VAL A 234
LEU A 237
ILE A 221
 None
 1.07A 4r38C-3nzrA:
undetectable		 4r38C-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		4 / 6 GLY A  98
THR A  97
SER A  77
VAL A  95
 None
 1.04A 5ewuA-3nzrA:
undetectable		 5ewuA-3nzrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		5 / 12 VAL A 144
ILE A 148
ALA A 149
LYS A 152
PHE A 185
 None
 0.80A 5j2tC-3nzrA:
undetectable		 5j2tC-3nzrA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE
(Aliivibrio
fischeri) 		5 / 12 LEU A 187
GLY A 115
ILE A 112
SER A  66
PHE A 162
 None
 0.71A 6ecxA-3nzrA:
undetectable		 6ecxA-3nzrA:
20.54