SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 7 VAL A 447
VAL A  20
ILE A 440
LEU A  26
 None
 0.93A 1iepB-3nztA:
undetectable		 1iepB-3nztA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 8 MET A 336
PHE A 142
PHE A 140
ILE A   7
 None
 1.15A 1pnlA-3nztA:
undetectable
1pnlB-3nztA:
undetectable		 1pnlA-3nztA:
18.47
1pnlB-3nztA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 5 TYR A 254
PHE A 251
TYR A 126
ARG A 125
 None
 1.43A 1qltA-3nztA:
undetectable		 1qltA-3nztA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 5 TYR A 254
PHE A 251
TYR A 126
ARG A 125
 None
 1.43A 1qltB-3nztA:
undetectable		 1qltB-3nztA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 7 GLU A 332
TYR A 405
LEU A 329
LYS A  65
 None
None
None
SO4  A 510 (-2.6A)
 1.01A 1rmtB-3nztA:
undetectable		 1rmtB-3nztA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 5 TYR A 254
PHE A 251
TYR A 126
ARG A 125
 None
 1.49A 1vaoA-3nztA:
undetectable		 1vaoA-3nztA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 5 TYR A 254
PHE A 251
TYR A 126
ARG A 125
 None
 1.48A 1vaoB-3nztA:
undetectable		 1vaoB-3nztA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 GLY A 181
ILE A 133
GLY A 135
ILE A 136
ALA A 283
 None
None
SO4  A 507 (-3.2A)
None
None
 0.88A 2b7zA-3nztA:
undetectable		 2b7zA-3nztA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 LYS A 287
ASP A  47
ASN A 278
 SO4  A 508 (-2.7A)
SO4  A 506 ( 4.0A)
SO4  A 508 ( 3.4A)
 1.09A 2bm9A-3nztA:
undetectable		 2bm9A-3nztA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 MET A 173
VAL A 409
GLU A 393
 None
 0.76A 2x9gA-3nztA:
undetectable		 2x9gA-3nztA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 ASN A   9
ARG A  11
PHE A 330
ASP A 407
PHE A 391
 None
 1.39A 3a25A-3nztA:
undetectable		 3a25A-3nztA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 LEU A 219
GLY A 220
SER A 217
ASN A 193
LEU A 198
 None
 1.10A 3cjtK-3nztA:
undetectable		 3cjtK-3nztA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 6 ASP A 487
ARG A 266
ILE A 484
ARG A 492
 None
 1.09A 3ckzA-3nztA:
undetectable		 3ckzA-3nztA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 GLY A 181
ILE A 133
GLY A 135
ILE A 136
ALA A 283
 None
None
SO4  A 507 (-3.2A)
None
None
 0.77A 3ekwB-3nztA:
undetectable		 3ekwB-3nztA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 ARG A 446
GLU A 319
TYR A  71
 None
 0.89A 3k37B-3nztA:
undetectable		 3k37B-3nztA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.71A 3pghA-3nztA:
undetectable		 3pghA-3nztA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.72A 3pghC-3nztA:
undetectable		 3pghC-3nztA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.86A 3rr3A-3nztA:
undetectable		 3rr3A-3nztA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.84A 3rr3B-3nztA:
undetectable		 3rr3B-3nztA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.85A 3rr3C-3nztA:
undetectable		 3rr3C-3nztA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.85A 3rr3D-3nztA:
undetectable		 3rr3D-3nztA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 6 SER A 134
LEU A  88
THR A  17
ARG A  15
 None
 1.49A 3thrB-3nztA:
undetectable		 3thrB-3nztA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 5 LEU A 269
ARG A 266
ILE A 484
ARG A 492
 None
 1.22A 3ticA-3nztA:
undetectable		 3ticA-3nztA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 7 ASN A  99
ILE A 101
PHE A  48
GLN A 102
 None
 1.26A 3tvxB-3nztA:
undetectable		 3tvxB-3nztA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 6 TYR A 118
ARG A 125
ASN A 270
TYR A 254
 None
 1.47A 3wfaA-3nztA:
undetectable
3wfaB-3nztA:
undetectable		 3wfaA-3nztA:
22.52
3wfaB-3nztA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 LYS A 115
TYR A 118
ARG A 119
 SO4  A 505 (-2.5A)
None
SO4  A 505 (-2.8A)
 1.27A 4gc9A-3nztA:
undetectable		 4gc9A-3nztA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_A_AICA401_1
(OUTER MEMBRANE
PROTEIN F)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 9 TYR A 254
GLY A 272
TYR A 281
SER A 282
ARG A 285
 None
None
None
None
SO4  A 506 (-2.9A)
 1.47A 4gcpA-3nztA:
0.0		 4gcpA-3nztA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GCP_B_AICB401_1
(OUTER MEMBRANE
PROTEIN F)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 9 TYR A 254
GLY A 272
TYR A 281
SER A 282
ARG A 285
 None
None
None
None
SO4  A 506 (-2.9A)
 1.47A 4gcpB-3nztA:
0.0		 4gcpB-3nztA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 8 ARG A 452
ASP A  84
ALA A  27
SER A  29
 None
 1.13A 4lv9A-3nztA:
undetectable
4lv9B-3nztA:
undetectable		 4lv9A-3nztA:
19.37
4lv9B-3nztA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 ALA A 283
GLY A 135
GLY A 181
LEU A 176
PRO A 177
 None
SO4  A 507 (-3.2A)
None
None
None
 1.30A 4uilH-3nztA:
undetectable
4uilL-3nztA:
undetectable		 4uilH-3nztA:
17.05
4uilL-3nztA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 8 ILE A 133
SER A  49
LEU A  26
ILE A 129
 None
 0.86A 4xtaB-3nztA:
undetectable		 4xtaB-3nztA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 9 GLN A 364
LEU A 370
LEU A 383
ALA A 211
ARG A 366
 None
 1.31A 5g44A-3nztA:
undetectable		 5g44A-3nztA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 6 VAL A  20
LEU A  88
CYH A  23
LEU A 441
 None
None
SO4  A 509 (-3.2A)
None
 1.22A 5hrqB-3nztA:
undetectable
5hrqI-3nztA:
undetectable
5hrqJ-3nztA:
undetectable		 5hrqB-3nztA:
5.15
5hrqI-3nztA:
3.06
5hrqJ-3nztA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 TYR A 494
LEU A 243
ALA A 246
ILE A 276
LEU A 259
 None
 1.31A 5ljbA-3nztA:
undetectable		 5ljbA-3nztA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 ARG A 215
ILE A 133
SER A  91
 SO4  A 507 (-3.8A)
None
None
 0.83A 5zw2A-3nztA:
undetectable		 5zw2A-3nztA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		3 / 3 ARG A 215
ILE A 133
SER A 134
 SO4  A 507 (-3.8A)
None
None
 0.83A 5zw2A-3nztA:
undetectable		 5zw2A-3nztA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		4 / 6 ASN A 278
TYR A 239
LEU A 274
SER A 282
 SO4  A 508 ( 3.4A)
None
None
None
 1.47A 6a7pB-3nztA:
undetectable		 6a7pB-3nztA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 GLY A  36
SER A 471
PHE A  76
ASN A  80
VAL A 461
 None
 1.31A 6a94A-3nztA:
undetectable		 6a94A-3nztA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 3nzt GLUTAMATE--CYSTEINE
LIGASE
(Francisella
tularensis) 		5 / 12 ILE A 276
GLU A 277
ARG A 295
GLU A 279
ARG A 125
 None
 1.25A 6ekuA-3nztA:
undetectable		 6ekuA-3nztA:
20.80