SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 12 GLY A  21
ASP A  45
ASP A  71
ASN A  98
ALA A  99
 NAP  A 273 (-3.7A)
NAP  A 273 (-2.9A)
NAP  A 273 (-3.4A)
NAP  A 273 (-3.2A)
NAP  A 273 (-3.6A)
 0.91A 2bm9E-3o03A:
5.8		 2bm9E-3o03A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 9 LEU A 235
ASP A 234
GLY A 260
ILE A 261
ILE A 191
 None
 0.97A 3s56B-3o03A:
undetectable		 3s56B-3o03A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 12 GLY A  90
ASP A  93
ILE A  63
ALA A  39
ALA A  35
 None
 0.98A 3sudC-3o03A:
undetectable		 3sudC-3o03A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		4 / 5 SER A 150
ILE A  26
TYR A 163
GLY A 194
 GCO  A 274 ( 2.6A)
NAP  A 273 (-3.8A)
GCO  A 274 ( 4.2A)
CA  A 272 (-4.5A)
 0.94A 3uboB-3o03A:
6.6		 3uboB-3o03A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		4 / 4 PHE A  43
ASP A  45
GLY A  67
SER A  23
 None
NAP  A 273 (-2.9A)
None
NAP  A 273 (-3.5A)
 1.42A 4xp9C-3o03A:
undetectable		 4xp9C-3o03A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 12 ALA A 243
LEU A  12
SER A 247
ALA A 246
LYS A 144
 None
 1.17A 4ypmA-3o03A:
2.3		 4ypmA-3o03A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 12 ILE A 148
ILE A 191
THR A 174
ASN A 251
ILE A 254
 NAP  A 273 (-4.2A)
None
None
None
None
 1.11A 5lg3E-3o03A:
undetectable		 5lg3E-3o03A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES
(Streptococcus
suis) 		5 / 12 ILE A 148
ILE A 191
THR A 174
ASN A 251
ILE A 254
 NAP  A 273 (-4.2A)
None
None
None
None
 1.06A 5lg3J-3o03A:
undetectable		 5lg3J-3o03A:
20.48