SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.71A 1c9sI-3o04A:
undetectable
1c9sJ-3o04A:
undetectable
1c9sI-3o04A:
12.22
1c9sJ-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.67A 1c9sU-3o04A:
undetectable
1c9sV-3o04A:
undetectable
1c9sU-3o04A:
12.22
1c9sV-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 6 LEU A 406
ARG A 358
TYR A 299
VAL A 238
None
1.07A 1db1A-3o04A:
undetectable
1db1A-3o04A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.72A 1gtnA-3o04A:
undetectable
1gtnB-3o04A:
undetectable
1gtnA-3o04A:
12.22
1gtnB-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 GLU A 113
ILE A 195
ILE A 231
ARG A  73
GLU A 233
None
1.45A 1ki7A-3o04A:
undetectable
1ki7A-3o04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 ILE A 195
ILE A 231
ALA A 344
ARG A  40
GLU A  53
None
1.44A 1ki7B-3o04A:
undetectable
1ki7B-3o04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 11 ILE A 105
ALA A  82
VAL A 147
ARG A 150
VAL A 101
None
1.26A 1n4hA-3o04A:
undetectable
1n4hA-3o04A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  78
None
1.32A 1nv8B-3o04A:
undetectable
1nv8B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  82
None
1.28A 1nv8B-3o04A:
undetectable
1nv8B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 11 ALA A 262
ALA A 286
VAL A 297
LEU A 329
MET A 283
None
1.10A 1rlbF-3o04A:
undetectable
1rlbF-3o04A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 PHE A  74
ILE A 187
ILE A 105
THR A  75
None
0.82A 1sbrA-3o04A:
undetectable
1sbrA-3o04A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 7 PHE A  74
ILE A 187
ILE A 105
THR A  75
None
0.78A 1sbrB-3o04A:
undetectable
1sbrB-3o04A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 4 THR A 305
GLY A 401
ASP A 265
ALA A 279
None
1.16A 1sg9A-3o04A:
undetectable
1sg9A-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  78
None
1.37A 1sg9B-3o04A:
undetectable
1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  82
None
1.24A 1sg9B-3o04A:
undetectable
1sg9B-3o04A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.80A 1utdB-3o04A:
undetectable
1utdC-3o04A:
undetectable
1utdB-3o04A:
12.22
1utdC-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.77A 1utdF-3o04A:
undetectable
1utdG-3o04A:
undetectable
1utdF-3o04A:
12.22
1utdG-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.76A 1utdI-3o04A:
undetectable
1utdJ-3o04A:
undetectable
1utdI-3o04A:
12.22
1utdJ-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 8 GLY A 143
ALA A  82
HIS A  76
ILE A 105
None
0.75A 1utdJ-3o04A:
undetectable
1utdK-3o04A:
undetectable
1utdJ-3o04A:
12.22
1utdK-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  78
None
1.38A 1vq1B-3o04A:
undetectable
1vq1B-3o04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ILE A 351
GLY A 236
GLY A 190
ILE A 171
VAL A  14
ALA A  82
None
1.16A 1vq1B-3o04A:
undetectable
1vq1B-3o04A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 ALA A  21
TYR A 254
ASP A 359
GLY A  12
ILE A  11
None
1.34A 2dcfA-3o04A:
undetectable
2dcfA-3o04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 8 GLY A 172
GLY A 261
THR A 405
ALA A 404
ALA A 262
None
0.97A 2ej3A-3o04A:
undetectable
2ej3A-3o04A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 10 GLY A 172
GLY A 261
THR A 405
ALA A 404
ALA A 262
None
0.94A 2ej3B-3o04A:
undetectable
2ej3B-3o04A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 HIS A 340
ALA A 208
GLY A 228
ASN A 212
LEU A 211
None
1.10A 2f8lA-3o04A:
undetectable
2f8lA-3o04A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 GLY A 347
GLY A 236
THR A 188
THR A  15
ALA A 350
None
0.99A 2gluB-3o04A:
undetectable
2gluB-3o04A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 ALA A 350
GLY A 347
GLY A 346
ALA A 404
GLY A 106
None
0.88A 2pkmA-3o04A:
undetectable
2pkmA-3o04A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 LEU A  91
GLY A 102
VAL A 238
ILE A 171
ILE A 239
None
0.87A 2pymB-3o04A:
undetectable
2pymB-3o04A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 LEU A  91
GLY A 102
VAL A 238
ILE A 171
ILE A 239
None
0.85A 2pynB-3o04A:
undetectable
2pynB-3o04A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 LEU A  91
GLY A 102
VAL A 238
ILE A 171
ILE A 239
None
0.88A 2q63B-3o04A:
undetectable
2q63B-3o04A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 LEU A  91
GLY A 102
VAL A 238
ILE A 171
ILE A 239
None
0.85A 2qakB-3o04A:
undetectable
2qakB-3o04A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 PHE A 408
VAL A 238
ALA A 350
SER A 396
ALA A 167
None
1.35A 2qm9A-3o04A:
undetectable
2qm9A-3o04A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 LEU A 354
ALA A  21
ASP A  20
ILE A 348
ALA A 350
ILE A 351
None
1.36A 2rkfB-3o04A:
undetectable
2rkfB-3o04A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 9 ALA A 191
ALA A  13
GLY A  12
GLY A 347
ILE A 348
None
1.24A 2v7bA-3o04A:
undetectable
2v7bA-3o04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 9 ALA A 191
ALA A  13
GLY A  12
GLY A 347
ILE A 348
None
1.25A 2v7bB-3o04A:
undetectable
2v7bB-3o04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 LEU A 406
GLY A 261
ALA A 262
ASN A 169
GLY A 189
None
0.95A 2vmyB-3o04A:
undetectable
2vmyB-3o04A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 10 ALA A  21
TYR A 254
ASP A 359
GLY A  12
ILE A  11
None
1.35A 2zm7A-3o04A:
0.0
2zm7A-3o04A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 11 ALA A  21
TYR A 254
ASP A 359
GLY A  12
ILE A  11
None
1.35A 2zmaA-3o04A:
undetectable
2zmaA-3o04A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 GLY A 339
GLY A 343
THR A 338
ASN A  33
VAL A  35
ILE A 230
None
1.24A 3elwA-3o04A:
undetectable
3elwA-3o04A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
3 / 3 SER A 170
GLY A 106
SER A 158
None
0.65A 3loqA-3o04A:
undetectable
3loqA-3o04A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 THR A 320
GLY A 276
ALA A 279
ALA A 282
ASN A 395
None
1.17A 3p5nA-3o04A:
undetectable
3p5nA-3o04A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 SER A 144
VAL A 161
ILE A 239
ILE A 237
PHE A  74
None
0.97A 3w67B-3o04A:
undetectable
3w67B-3o04A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 9 ALA A 191
ALA A  13
GLY A  12
GLY A 347
ILE A 348
None
1.14A 4eatB-3o04A:
undetectable
4eatB-3o04A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 6 ALA A 350
LEU A 406
VAL A 407
GLU A 256
None
0.97A 4g24A-3o04A:
undetectable
4g24A-3o04A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 VAL A  48
GLY A 232
GLY A 339
ILE A 195
LEU A 200
None
1.05A 4iv0A-3o04A:
undetectable
4iv0A-3o04A:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
11 / 12 GLY A 108
ALA A 163
CYH A 164
GLU A 192
SER A 199
PHE A 203
HIS A 303
THR A 305
HIS A 340
LEU A 342
GLY A 398
None
0.54A 4ls7A-3o04A:
74.5
4ls7A-3o04A:
68.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
8 / 12 GLY A 108
ALA A 163
GLU A 192
SER A 199
PHE A 203
LEU A 342
GLY A 398
PHE A 399
None
0.80A 4ls7A-3o04A:
74.5
4ls7A-3o04A:
68.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
9 / 12 ALA A 163
CYH A 164
SER A 199
PHE A 203
HIS A 303
THR A 305
HIS A 340
LEU A 342
GLY A 398
None
0.57A 4ls7A-3o04A:
74.5
4ls7B-3o04A:
74.0
4ls7A-3o04A:
68.31
4ls7B-3o04A:
68.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
6 / 12 ALA A 163
SER A 199
PHE A 203
LEU A 342
GLY A 398
PHE A 399
None
0.87A 4ls7A-3o04A:
74.5
4ls7B-3o04A:
74.0
4ls7A-3o04A:
68.31
4ls7B-3o04A:
68.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 ILE A 109
ALA A 163
CYH A 164
HIS A 303
GLY A 398
None
0.82A 4ls7A-3o04A:
74.5
4ls7B-3o04A:
74.0
4ls7A-3o04A:
68.31
4ls7B-3o04A:
68.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 VAL A  48
GLY A 232
GLY A 339
ILE A 195
LEU A 200
None
1.01A 4mwzB-3o04A:
undetectable
4mwzB-3o04A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 11 GLY A 102
VAL A 238
ILE A 171
THR A   9
ILE A 239
None
0.91A 4njvC-3o04A:
undetectable
4njvC-3o04A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 5 ILE A 331
ARG A 226
GLU A 314
VAL A 321
None
1.21A 4nkxC-3o04A:
undetectable
4nkxC-3o04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 5 ILE A 331
ARG A 226
GLU A 314
VAL A 321
None
1.20A 4nkxD-3o04A:
undetectable
4nkxD-3o04A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 6 ALA A  78
ILE A 109
SER A 170
ILE A 105
VAL A 161
None
1.40A 4r21A-3o04A:
undetectable
4r21A-3o04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 5 THR A 263
GLY A 278
GLU A 314
HIS A 303
None
1.16A 5c0oH-3o04A:
undetectable
5c0oH-3o04A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 GLY A 234
GLY A 347
GLU A 349
VAL A   8
ILE A  11
None
1.05A 5ehiC-3o04A:
undetectable
5ehiC-3o04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 12 GLY A 234
GLY A 347
SER A 345
GLY A  18
SER A  24
None
1.25A 5hikA-3o04A:
undetectable
5hikA-3o04A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 9 PHE A 408
GLU A 256
LEU A 406
ILE A 171
PHE A 175
None
1.47A 5i73A-3o04A:
undetectable
5i73A-3o04A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 5 THR A 217
HIS A 367
ALA A 218
ASP A 214
None
1.25A 5mfxA-3o04A:
undetectable
5mfxA-3o04A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 6 TYR A 313
ASP A 311
HIS A 303
TYR A 267
None
1.25A 5ov9A-3o04A:
undetectable
5ov9A-3o04A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 7 TYR A 313
ASP A 311
HIS A 303
TYR A 267
None
1.28A 5ov9B-3o04A:
undetectable
5ov9B-3o04A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
5 / 11 ASP A 173
VAL A 147
ILE A 105
THR A 159
ILE A 237
None
1.27A 5y80A-3o04A:
undetectable
5y80A-3o04A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes)
4 / 6 VAL A  86
ILE A 239
GLU A 241
ARG A 249
None
0.99A 5z3jA-3o04A:
undetectable
5z3jA-3o04A:
20.05