SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 200
GLU A 169
LEU A 195
LEU A 135
GLY A 132
 None
 1.44A 1d4fB-3o07A:
undetectable		 1d4fB-3o07A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 217
ALA A 219
ASP A 220
LEU A 223
LEU A 265
 None
 1.17A 1errA-3o07A:
undetectable		 1errA-3o07A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 140
LYS A 117
ASP A 130
GLU A 102
 None
 1.11A 1knyA-3o07A:
undetectable
1knyB-3o07A:
undetectable		 1knyA-3o07A:
22.22
1knyB-3o07A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  88
LYS A  80
VAL A  81
 None
 0.95A 1l2iA-3o07A:
undetectable		 1l2iA-3o07A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 166
GLY A 132
GLU A 133
ALA A 134
THR A 147
 None
 1.37A 2dtjA-3o07A:
undetectable
2dtjB-3o07A:
undetectable		 2dtjA-3o07A:
20.34
2dtjB-3o07A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 255
ALA A 254
ALA A 221
VAL A 234
GLY A  37
 None
 0.96A 2f16K-3o07A:
undetectable
2f16L-3o07A:
undetectable		 2f16K-3o07A:
22.76
2f16L-3o07A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 255
ALA A 254
ALA A 221
VAL A 234
GLY A  37
 None
 0.96A 2f16Y-3o07A:
undetectable
2f16Z-3o07A:
undetectable		 2f16Y-3o07A:
22.76
2f16Z-3o07A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 205
PRO A 206
ARG A 137
 None
 0.53A 2qd4B-3o07A:
2.0		 2qd4B-3o07A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 205
PRO A 206
ARG A 137
 None
 0.66A 2qd5A-3o07A:
1.8		 2qd5A-3o07A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 128
ILE A 166
PRO A 206
VAL A 207
ILE A 145
 None
 0.96A 3lzvB-3o07A:
undetectable		 3lzvB-3o07A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 166
GLY A 132
PRO A 206
VAL A 207
ILE A 145
 None
 1.00A 3nu6A-3o07A:
undetectable		 3nu6A-3o07A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 166
GLY A 132
PRO A 206
VAL A 207
ILE A 145
 None
 1.12A 3nuoA-3o07A:
undetectable		 3nuoA-3o07A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 128
ILE A 166
PRO A 206
VAL A 207
ILE A 145
 None
 0.93A 3oxvB-3o07A:
undetectable		 3oxvB-3o07A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 166
GLY A 132
PRO A 206
VAL A 207
ILE A 145
 None
 1.03A 3oxvB-3o07A:
undetectable		 3oxvB-3o07A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  23
LEU A  44
ASP A 101
GLU A 104
ARG A 146
 None
 1.48A 4b9zA-3o07A:
undetectable		 4b9zA-3o07A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  71
ASP A  68
ILE A  69
ALA A  30
VAL A  24
 None
 1.15A 4dx5B-3o07A:
undetectable		 4dx5B-3o07A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 6 SER A 103
ARG A 146
GLY A 214
GLY A 152
 None
 0.89A 4koeA-3o07A:
undetectable
4koeB-3o07A:
undetectable
4koeC-3o07A:
undetectable		 4koeA-3o07A:
21.91
4koeB-3o07A:
21.91
4koeC-3o07A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 146
SER A 103
GLY A 214
GLY A 152
 None
 0.89A 4koeA-3o07A:
undetectable
4koeB-3o07A:
undetectable
4koeD-3o07A:
undetectable		 4koeA-3o07A:
21.91
4koeB-3o07A:
21.91
4koeD-3o07A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  71
ASP A  68
ILE A  69
ALA A  30
VAL A  24
 None
 1.16A 4u8vB-3o07A:
undetectable		 4u8vB-3o07A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  71
ASP A  68
ILE A  69
ALA A  30
VAL A  24
 None
 1.14A 4u8yB-3o07A:
undetectable		 4u8yB-3o07A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  71
ASP A  68
ILE A  69
ALA A  30
VAL A  24
 None
 1.15A 4u95B-3o07A:
undetectable		 4u95B-3o07A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 217
ALA A 219
ASP A 220
LEU A 223
LEU A 265
 None
 1.20A 4xi3A-3o07A:
undetectable		 4xi3A-3o07A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 214
GLY A 152
SER A 103
ARG A 146
 None
 0.82A 4z53A-3o07A:
undetectable
4z53B-3o07A:
undetectable		 4z53A-3o07A:
18.06
4z53B-3o07A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 146
GLY A 214
GLY A 152
SER A 103
 None
 0.84A 4z53A-3o07A:
undetectable
4z53B-3o07A:
undetectable		 4z53A-3o07A:
18.06
4z53B-3o07A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 160
ALA A 159
GLY A 213
GLY A 154
 None
 0.91A 5e26C-3o07A:
undetectable
5e26D-3o07A:
undetectable		 5e26C-3o07A:
21.52
5e26D-3o07A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 254
ALA A 221
VAL A 232
LEU A 247
VAL A 234
 None
 1.08A 5eb5A-3o07A:
undetectable		 5eb5A-3o07A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 254
ALA A 221
VAL A 232
LEU A 247
VAL A 234
 None
 1.12A 5eb5B-3o07A:
undetectable		 5eb5B-3o07A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 214
PHE A 233
VAL A 232
ILE A  47
ALA A  49
 None
 1.02A 5n0xA-3o07A:
undetectable		 5n0xA-3o07A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 165
LYS A 161
ARG A  52
 None
 1.27A 6c06D-3o07A:
undetectable		 6c06D-3o07A:
undetectable