SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 10 VAL A 184
VAL A 201
ILE A  85
PRO A 182
GLY A 172
 None
 1.29A 13gsA-3o0dA:
undetectable		 13gsA-3o0dA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 9 VAL A 184
VAL A 201
ILE A  85
PRO A 182
GLY A 172
 None
 1.29A 13gsB-3o0dA:
undetectable		 13gsB-3o0dA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 12 GLY A  32
HIS A  60
ILE A 140
LEU A 144
LEU A  55
 None
None
None
NAG  A 302 ( 4.9A)
None
 0.98A 1r30B-3o0dA:
undetectable		 1r30B-3o0dA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		4 / 7 TYR A  82
GLN A 155
TYR A 154
ILE A  56
 None
 1.18A 2ph9A-3o0dA:
undetectable
2ph9B-3o0dA:
undetectable		 2ph9A-3o0dA:
23.66
2ph9B-3o0dA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_2
(GLUCOCORTICOID
RECEPTOR)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		4 / 5 LEU A 175
ASN A 178
TRP A 200
TYR A 133
 NAG  A 302 (-4.8A)
NAG  A 302 (-3.4A)
None
None
 1.11A 3h52D-3o0dA:
0.0		 3h52D-3o0dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 10 VAL A 201
ILE A 173
ALA A 166
ILE A 130
VAL A 125
 None
None
None
NAG  A 303 (-4.5A)
None
 1.07A 3me6A-3o0dA:
undetectable		 3me6A-3o0dA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		4 / 6 PHE A 108
PHE A 197
ALA A 167
THR A 136
 None
 1.16A 3t3sB-3o0dA:
undetectable		 3t3sB-3o0dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		6 / 12 LEU A 170
LEU A 169
ILE A 173
ASN A 199
GLY A 193
VAL A 192
 None
None
None
None
None
K  A 308 ( 4.6A)
 1.19A 4an2A-3o0dA:
undetectable		 4an2A-3o0dA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 12 LEU A  83
PHE A  59
ASP A  61
ASP A  67
GLY A  87
 None
 1.30A 4j7xF-3o0dA:
2.4		 4j7xF-3o0dA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 12 GLY A 172
TYR A 133
GLU A  57
SER A 146
ILE A 148
 None
 1.42A 5igwA-3o0dA:
undetectable		 5igwA-3o0dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3o0d TRIACYLGLYCEROL
LIPASE
(Yarrowia
lipolytica) 		5 / 11 VAL A 158
VAL A 147
LEU A 144
ALA A 167
PHE A  59
 None
None
NAG  A 302 ( 4.9A)
None
None
 1.32A 6dryA-3o0dA:
undetectable		 6dryA-3o0dA:
22.49