SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 SER A 160
ILE A 181
LEU A 206
PHE A 185
ALA A 343
 FAD  A 500 (-3.8A)
FAD  A 500 ( 4.3A)
None
None
None
 1.11A 1tlsA-3o0hA:
undetectable		 1tlsA-3o0hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 SER A 160
ILE A 181
LEU A 206
PHE A 185
ALA A 343
 FAD  A 500 (-3.8A)
FAD  A 500 ( 4.3A)
None
None
None
 1.08A 1tsnA-3o0hA:
undetectable		 1tsnA-3o0hA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 GLY A  17
GLY A  16
GLY A 304
PHE A   9
SER A  13
 None
FAD  A 500 (-3.5A)
FAD  A 500 (-3.3A)
None
FAD  A 500 ( 4.4A)
 1.20A 1wg8A-3o0hA:
3.6		 1wg8A-3o0hA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		4 / 4 ALA A 115
VAL A  10
PHE A 117
THR A 141
 FAD  A 500 (-4.1A)
None
None
FAD  A 500 (-3.9A)
 1.40A 2pkkA-3o0hA:
2.7		 2pkkA-3o0hA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 PHE A 117
VAL A 279
PHE A 323
PHE A 328
ALA A 134
 None
 1.14A 3apwA-3o0hA:
undetectable		 3apwA-3o0hA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		4 / 7 THR A 342
GLY A 351
VAL A 406
GLY A 403
 None
 0.81A 4forA-3o0hA:
undetectable		 4forA-3o0hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		4 / 7 PHE A   4
ASP A   5
THR A 122
ASP A 119
 None
 0.96A 4pcuA-3o0hA:
2.8		 4pcuA-3o0hA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		3 / 3 ASP A 338
LEU A 355
GLY A 354
 None
 0.44A 4xmfA-3o0hA:
undetectable		 4xmfA-3o0hA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		4 / 6 GLU A 112
GLY A 304
ASP A 305
GLY A  16
 None
FAD  A 500 (-3.3A)
FAD  A 500 (-2.7A)
FAD  A 500 (-3.5A)
 0.64A 5cdpA-3o0hA:
undetectable
5cdpB-3o0hA:
undetectable		 5cdpA-3o0hA:
21.85
5cdpB-3o0hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 TYR A  99
GLY A  40
PHE A 345
ILE A 414
GLY A 412
 None
 1.07A 5fsaB-3o0hA:
undetectable		 5fsaB-3o0hA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		3 / 3 PRO A 385
ARG A 375
GLU A 386
 None
 0.98A 5j6hA-3o0hA:
undetectable		 5j6hA-3o0hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 9 GLY A 142
VAL A 306
ALA A 302
LEU A 138
LEU A 272
 FAD  A 500 (-3.2A)
None
None
None
FAD  A 500 ( 4.5A)
 0.99A 5lw1H-3o0hA:
undetectable		 5lw1H-3o0hA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		4 / 8 THR A 333
PRO A 335
TYR A 337
VAL A 315
 None
 0.77A 5nzyA-3o0hA:
undetectable		 5nzyA-3o0hA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 10 HIS A 200
ILE A 175
GLY A 182
GLY A 179
LEU A 261
 None
 0.78A 5o96C-3o0hA:
3.0
5o96D-3o0hA:
2.7		 5o96C-3o0hA:
19.62
5o96D-3o0hA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 10 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 268
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.3A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.5A)
 0.81A 6exiA-3o0hA:
3.7		 6exiA-3o0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 10 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 268
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.3A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.5A)
 0.82A 6exiB-3o0hA:
3.6		 6exiB-3o0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 268
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.3A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.5A)
 0.83A 6exiC-3o0hA:
3.9
6exiD-3o0hA:
3.9		 6exiC-3o0hA:
10.96
6exiD-3o0hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3o0h GLUTATHIONE
REDUCTASE
(Bartonella
henselae) 		5 / 12 GLY A  12
GLY A  14
GLU A  35
THR A 141
ASN A 268
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.3A)
FAD  A 500 (-2.6A)
FAD  A 500 (-3.9A)
FAD  A 500 ( 4.5A)
 0.83A 6exiC-3o0hA:
3.9
6exiD-3o0hA:
3.9		 6exiC-3o0hA:
10.96
6exiD-3o0hA:
10.96