SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 THR A 139
THR A 105
THR A  92
HIS A 127
 None
None
None
GOL  A 300 (-4.1A)
 1.05A 1d4fB-3o0kA:
undetectable		 1d4fB-3o0kA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 11 LEU A 278
THR A 276
THR A 219
ILE A 234
VAL A 231
 None
 1.02A 1pkvA-3o0kA:
undetectable
1pkvB-3o0kA:
undetectable		 1pkvA-3o0kA:
20.20
1pkvB-3o0kA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 11 ILE A 234
VAL A 231
LEU A 278
THR A 276
THR A 219
 None
 1.02A 1pkvA-3o0kA:
undetectable
1pkvB-3o0kA:
undetectable		 1pkvA-3o0kA:
20.20
1pkvB-3o0kA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 TRP A  41
TYR A  69
HIS A 127
TRP A 128
 GOL  A 300 (-4.5A)
GOL  A 300 (-4.7A)
GOL  A 300 (-4.1A)
GOL  A 300 ( 4.8A)
 0.91A 2ineA-3o0kA:
35.2		 2ineA-3o0kA:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 TRP A  41
TYR A  69
HIS A 127
TRP A 128
 GOL  A 300 (-4.5A)
GOL  A 300 (-4.7A)
GOL  A 300 (-4.1A)
GOL  A 300 ( 4.8A)
 0.97A 2isfA-3o0kA:
35.1		 2isfA-3o0kA:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 12 LEU A  36
GLU A 258
LEU A 209
ILE A 235
HIS A 239
 None
 1.40A 2ydoA-3o0kA:
undetectable		 2ydoA-3o0kA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 7 TRP A  41
TYR A  69
HIS A 127
TRP A 128
 GOL  A 300 (-4.5A)
GOL  A 300 (-4.7A)
GOL  A 300 (-4.1A)
GOL  A 300 ( 4.8A)
 0.90A 3s3gA-3o0kA:
35.3		 3s3gA-3o0kA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 9 ALA A 202
ILE A  33
GLY A 156
ILE A 247
ILE A 245
 None
 0.95A 3s43A-3o0kA:
undetectable		 3s43A-3o0kA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 ILE A 247
SER A 250
LYS A 249
GLY A  39
 None
 1.15A 3tkdB-3o0kA:
undetectable		 3tkdB-3o0kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 ILE A 247
SER A 250
LYS A 249
GLY A  39
 None
 1.14A 3tkdA-3o0kA:
undetectable		 3tkdA-3o0kA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 8 TRP A  41
TRP A  96
HIS A 127
TRP A 128
 GOL  A 300 (-4.5A)
None
GOL  A 300 (-4.1A)
GOL  A 300 ( 4.8A)
 0.70A 3v35A-3o0kA:
35.6		 3v35A-3o0kA:
36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 PHE A  90
LEU A 178
GLY A 156
VAL A 152
 None
 0.90A 3wrkD-3o0kA:
undetectable		 3wrkD-3o0kA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 LEU A 165
TRP A 140
ILE A 155
ASN A  31
 None
 1.49A 4i00A-3o0kA:
undetectable		 4i00A-3o0kA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 9 PHE A 109
SER A 112
THR A 118
VAL A 152
LEU A  91
 None
 1.21A 4wnvA-3o0kA:
undetectable		 4wnvA-3o0kA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 12 TYR A  69
TRP A  96
HIS A 127
MET A 130
ASN A 159
 GOL  A 300 (-4.7A)
None
GOL  A 300 (-4.1A)
None
GOL  A 300 ( 3.5A)
 0.65A 4yvxB-3o0kA:
35.7		 4yvxB-3o0kA:
39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 9 TYR A  69
TRP A  96
HIS A 127
MET A 130
ASN A 159
 GOL  A 300 (-4.7A)
None
GOL  A 300 (-4.1A)
None
GOL  A 300 ( 3.5A)
 0.64A 4zfcB-3o0kA:
36.0		 4zfcB-3o0kA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 ARG A 151
GLY A 150
GLU A 149
ARG A  86
 None
 1.08A 5cdqA-3o0kA:
undetectable
5cdqB-3o0kA:
undetectable
5cdqC-3o0kA:
undetectable		 5cdqA-3o0kA:
23.09
5cdqB-3o0kA:
21.74
5cdqC-3o0kA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 5 THR A  65
ALA A  66
THR A  93
TYR A 124
 None
 1.10A 5ecmA-3o0kA:
undetectable		 5ecmA-3o0kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 6 THR A  65
ALA A  66
THR A  93
TYR A 124
 None
 1.02A 5ecoA-3o0kA:
2.0		 5ecoA-3o0kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 12 ALA A 232
LEU A 236
GLY A 210
SER A 207
PRO A 248
 None
 1.38A 5jglB-3o0kA:
undetectable		 5jglB-3o0kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 9 PHE A 187
THR A 203
ASN A 179
ILE A 181
 None
None
None
EDO  A 301 ( 4.3A)
 0.93A 5lg3I-3o0kA:
undetectable		 5lg3I-3o0kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 8 SER A 154
ASN A  31
HIS A  32
LEU A  27
 None
 0.96A 5m8rB-3o0kA:
undetectable		 5m8rB-3o0kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		4 / 8 SER A 154
ASN A  31
HIS A  32
LEU A  27
 None
 0.95A 5m8rD-3o0kA:
undetectable		 5m8rD-3o0kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3o0k ALDO/KETO REDUCTASE
(Brucella
abortus) 		5 / 12 THR A  65
ALA A  66
ILE A 247
GLY A  39
LEU A 125
 None
 0.87A 5nfjA-3o0kA:
undetectable		 5nfjA-3o0kA:
22.30