SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 0.76A 1fbyA-3o0mA:
undetectable		 1fbyA-3o0mA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 0.75A 1fbyB-3o0mA:
undetectable		 1fbyB-3o0mA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.63A 1fm6A-3o0mA:
undetectable		 1fm6A-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.19A 1fm9A-3o0mA:
undetectable		 1fm9A-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 1k74A-3o0mA:
undetectable		 1k74A-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.66A 1xdkE-3o0mA:
undetectable		 1xdkE-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.70A 1xiuA-3o0mA:
undetectable		 1xiuA-3o0mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 1.23A 1xiuB-3o0mA:
undetectable		 1xiuB-3o0mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.18A 1xlsA-3o0mA:
undetectable		 1xlsA-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.18A 1xlsB-3o0mA:
undetectable		 1xlsB-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.18A 1xlsC-3o0mA:
undetectable		 1xlsC-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.18A 1xlsD-3o0mA:
undetectable		 1xlsD-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 2aclG-3o0mA:
undetectable		 2aclG-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.56A 3falC-3o0mA:
undetectable		 3falC-3o0mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.53A 3fc6A-3o0mA:
undetectable		 3fc6A-3o0mA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A 124
GLU A 126
GLU A 127
ARG A 130
 ACT  A 146 (-2.8A)
None
None
ACT  A 146 (-2.9A)
 0.00A 3o0mA-3o0mA:
30.4		 3o0mA-3o0mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-3.8A)
AMP  A 155 (-4.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.37A 3o1cA-3o0mA:
14.6		 3o1cA-3o0mA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-3.8A)
AMP  A 155 (-4.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.34A 3o1xA-3o0mA:
14.6		 3o1xA-3o0mA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.70A 3oapA-3o0mA:
undetectable		 3oapA-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-3.8A)
AMP  A 155 (-4.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.38A 3qgzA-3o0mA:
14.7		 3qgzA-3o0mA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.54A 4k6iA-3o0mA:
undetectable		 4k6iA-3o0mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A  67
ALA A  71
LEU A 136
ALA A 135
HIS A 101
 None
None
None
None
AMP  A 155 (-3.8A)
 0.73A 4nqaA-3o0mA:
undetectable		 4nqaA-3o0mA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
HIS A 101
 None
None
None
None
AMP  A 155 (-3.8A)
 0.46A 4nqaH-3o0mA:
undetectable		 4nqaH-3o0mA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  -1
CYH A   6
CYH A   3
 None
ZN  A 151 (-2.3A)
ZN  A 151 (-2.2A)
 0.77A 5inzB-3o0mA:
undetectable		 5inzB-3o0mA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ASN A  86
ALA A  91
GLN A  93
HIS A  99
HIS A 101
 AMP  A 155 (-4.1A)
None
None
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 1.42A 5km8A-3o0mA:
11.5
5km8B-3o0mA:
14.4		 5km8A-3o0mA:
26.99
5km8B-3o0mA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		7 / 12 PHE A   5
ILE A   8
ASP A  29
LEU A  39
VAL A  95
HIS A  99
HIS A 101
 None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-4.8A)
AMP  A 155 (-4.5A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.37A 5km9B-3o0mA:
14.6		 5km9B-3o0mA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
 None
 0.64A 5uanA-3o0mA:
undetectable		 5uanA-3o0mA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 PHE A   5
ILE A   8
ILE A  30
THR A  94
VAL A  95
HIS A  99
 None
None
AMP  A 155 (-3.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-4.5A)
AMP  A 155 (-3.7A)
 1.42A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		11 / 12 VAL A   4
PHE A   5
ILE A   8
ILE A  27
ASP A  29
ILE A  30
LEU A  39
THR A  94
VAL A  95
HIS A  99
HIS A 101
 AMP  A 155 (-4.7A)
None
None
None
AMP  A 155 (-2.7A)
AMP  A 155 (-3.8A)
AMP  A 155 (-4.8A)
AMP  A 155 (-3.7A)
AMP  A 155 (-4.5A)
AMP  A 155 (-3.7A)
AMP  A 155 (-3.8A)
 0.44A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  95
ILE A  41
LEU A  39
HIS A 101
HIS A  37
 AMP  A 155 (-4.5A)
None
AMP  A 155 (-4.8A)
AMP  A 155 (-3.8A)
None
 1.00A 5uvmB-3o0mA:
15.1		 5uvmB-3o0mA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 5z12B-3o0mA:
undetectable		 5z12B-3o0mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 0.87A 6a5zL-3o0mA:
undetectable		 6a5zL-3o0mA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o0m HIT FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  67
ALA A  70
ALA A  71
LEU A  76
ALA A 135
HIS A 101
 None
None
None
None
None
AMP  A 155 (-3.8A)
 1.22A 6a60D-3o0mA:
undetectable		 6a60D-3o0mA:
24.11