SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 8 GLU A  62
ARG A  65
ARG A  66
LEU A  58
 None
 0.93A 1cmaA-3o0pA:
undetectable
1cmaB-3o0pA:
undetectable		 1cmaA-3o0pA:
19.02
1cmaB-3o0pA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 11 GLY A 125
SER A 126
LEU A 131
ILE A 108
ALA A  99
 None
 1.40A 2a58A-3o0pA:
undetectable
2a58E-3o0pA:
undetectable		 2a58A-3o0pA:
23.15
2a58E-3o0pA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 11 ILE A 108
ALA A  99
GLY A 125
SER A 126
LEU A 131
 None
 1.40A 2a58C-3o0pA:
undetectable
2a58D-3o0pA:
undetectable		 2a58C-3o0pA:
23.15
2a58D-3o0pA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A 134
ALA A 135
ILE A 108
GLY A 125
THR A 152
ILE A 154
 None
 1.48A 2nmyA-3o0pA:
undetectable		 2nmyA-3o0pA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 5 LEU A 230
LEU A 138
CYH A 219
THR A 220
 None
 1.36A 2oaxD-3o0pA:
undetectable		 2oaxD-3o0pA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 7 TYR A 213
GLN A 193
TYR A 189
ILE A 236
 None
 1.15A 2ph9A-3o0pA:
undetectable
2ph9B-3o0pA:
undetectable		 2ph9A-3o0pA:
20.58
2ph9B-3o0pA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 LEU A 143
PRO A 144
ARG A  66
 None
 0.36A 2qd4B-3o0pA:
undetectable		 2qd4B-3o0pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A 134
ALA A 135
ILE A 108
GLY A 125
THR A 152
ILE A 154
 None
 1.46A 3d1yA-3o0pA:
undetectable		 3d1yA-3o0pA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 10 ILE A 180
ILE A 122
GLY A 125
PRO A  85
LEU A 143
 None
 1.19A 3elzC-3o0pA:
undetectable		 3elzC-3o0pA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 4 LEU A 143
PRO A 144
LEU A 102
ARG A 100
 None
 1.02A 3hcoB-3o0pA:
undetectable		 3hcoB-3o0pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 6 VAL A 153
VAL A 113
ILE A 122
ARG A 228
 None
 1.11A 3ms9A-3o0pA:
undetectable		 3ms9A-3o0pA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_C_0HKC2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 12 ASN A 182
THR A 141
THR A 152
TYR A  73
ASN A  74
 None
 1.32A 4dajC-3o0pA:
undetectable		 4dajC-3o0pA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		5 / 7 LEU A 169
THR A 218
GLY A 136
ALA A 156
ILE A 122
 None
 1.19A 4yjiA-3o0pA:
undetectable		 4yjiA-3o0pA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		6 / 12 GLY A 134
ALA A 135
ILE A 108
GLY A 125
THR A 152
ILE A 154
 None
 1.46A 5kqxA-3o0pA:
undetectable		 5kqxA-3o0pA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		3 / 3 THR A 215
THR A 220
LEU A 252
 None
 0.52A 5m66D-3o0pA:
undetectable		 5m66D-3o0pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3o0p SORTASE FAMILY
PROTEIN
(Streptococcus
agalactiae) 		4 / 4 LEU A 217
ASP A  84
PRO A  85
ARG A 228
 None
 1.20A 6fgdA-3o0pA:
undetectable		 6fgdA-3o0pA:
20.33