SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 10 LEU B  63
ALA B 453
MET B 393
LEU B  32
GLN B  30
 None
None
None
None
HEM  B 801 (-3.5A)
 1.15A 1aqbA-3o0rB:
undetectable		 1aqbA-3o0rB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 234
THR B 230
VAL B 227
 None
 0.85A 1hxbA-3o0rB:
undetectable		 1hxbA-3o0rB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 11 LEU B  63
ALA B 453
MET B 393
LEU B  32
GLN B  30
 None
None
None
None
HEM  B 801 (-3.5A)
 1.23A 1kt6A-3o0rB:
undetectable		 1kt6A-3o0rB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 11 LEU B  63
ALA B 453
MET B 393
LEU B  32
GLN B  30
 None
None
None
None
HEM  B 801 (-3.5A)
 1.16A 1kt7A-3o0rB:
undetectable		 1kt7A-3o0rB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 12 TYR B 268
GLY B 273
GLU B 280
SER B 277
PHE B 261
 None
None
HEM  B 802 (-4.4A)
HEM  B 802 ( 4.8A)
None
 1.47A 1maaA-3o0rB:
undetectable		 1maaA-3o0rB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 TRP B  95
PHE B  98
TRP B  99
 None
 1.03A 1r15C-3o0rB:
undetectable		 1r15C-3o0rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 TRP B  95
PHE B  98
TRP B  99
 None
 1.01A 1r15F-3o0rB:
undetectable		 1r15F-3o0rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 TRP B  95
PHE B  98
TRP B  99
 None
 1.02A 1r15G-3o0rB:
undetectable		 1r15G-3o0rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 TRP B  95
PHE B  98
TRP B  99
 None
 1.02A 1r15H-3o0rB:
undetectable		 1r15H-3o0rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 10 GLY B 255
GLY B 257
GLU B 280
SER B 277
PHE B 261
 None
None
HEM  B 802 (-4.4A)
HEM  B 802 ( 4.8A)
None
 1.06A 1w76B-3o0rB:
undetectable		 1w76B-3o0rB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		4 / 7 PHE B  27
LEU B  68
PHE B 447
VAL B 398
 None
None
HEM  B 801 ( 4.5A)
None
 1.10A 1wrlA-3o0rB:
undetectable
1wrlB-3o0rB:
undetectable		 1wrlA-3o0rB:
11.90
1wrlB-3o0rB:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 12 ARG B 300
ILE B 229
TYR B  78
ARG B 370
TYR B 302
 None
 1.42A 2f10A-3o0rB:
undetectable		 2f10A-3o0rB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		4 / 8 TYR B 366
GLU B  82
PHE B 224
VAL B 307
 None
 1.09A 2fl5E-3o0rB:
undetectable
2fl5F-3o0rB:
undetectable		 2fl5E-3o0rB:
18.10
2fl5F-3o0rB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3o0r ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Mus
musculus) 		4 / 5 VAL L 132
VAL L 159
GLY L 158
TRP L 148
 None
 1.15A 2p2fA-3o0rL:
undetectable		 2p2fA-3o0rL:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 234
THR B 230
VAL B 227
 None
 0.79A 2q64A-3o0rB:
undetectable		 2q64A-3o0rB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 234
THR B 230
VAL B 227
 None
 0.95A 2qakA-3o0rB:
undetectable		 2qakA-3o0rB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 166
GLY B 165
SER B  12
 None
 0.49A 2xctB-3o0rB:
undetectable		 2xctB-3o0rB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		4 / 7 THR B 315
LEU B 222
VAL B 225
THR B 230
 None
 0.75A 3fwiA-3o0rB:
undetectable		 3fwiA-3o0rB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		6 / 12 VAL B 158
ALA B  76
LEU B 184
LEU B 181
ILE B 217
ALA B 220
 None
 1.28A 3gp0A-3o0rB:
undetectable		 3gp0A-3o0rB:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3o0r ANTIBODY FAB
FRAGMENT LIGHT CHAIN
(Mus
musculus) 		4 / 5 TYR L  36
GLN L  89
LEU L  96
PHE L  98
 None
 0.53A 3ls4L-3o0rL:
27.1		 3ls4L-3o0rL:
82.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 11 TYR B 268
GLY B 273
GLU B 280
HIS B 207
GLY B 252
 None
None
HEM  B 802 (-4.4A)
FE  B 803 (-3.3A)
None
 1.14A 4ey7A-3o0rB:
undetectable		 4ey7A-3o0rB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 11 TYR B 268
GLY B 273
GLU B 280
SER B 277
GLY B 252
 None
None
HEM  B 802 (-4.4A)
HEM  B 802 ( 4.8A)
None
 1.40A 4ey7A-3o0rB:
undetectable		 4ey7A-3o0rB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 11 TYR B 268
GLY B 273
GLU B 280
HIS B 207
GLY B 252
 None
None
HEM  B 802 (-4.4A)
FE  B 803 (-3.3A)
None
 1.14A 4ey7B-3o0rB:
undetectable		 4ey7B-3o0rB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		4 / 7 TYR B 112
TYR B 117
LEU B 120
ASN B 126
 None
 1.23A 4f8yC-3o0rB:
undetectable
4f8yD-3o0rB:
undetectable		 4f8yC-3o0rB:
16.06
4f8yD-3o0rB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 12 MET B 218
GLY B 177
LEU B 249
ILE B 359
PHE B  72
 None
 1.21A 4p6xA-3o0rB:
undetectable		 4p6xA-3o0rB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 10 ILE B 364
LEU B  63
GLN B  30
LEU B  68
PHE B  20
 None
None
HEM  B 801 (-3.5A)
None
None
 1.50A 4r3aB-3o0rB:
undetectable		 4r3aB-3o0rB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 408
GLN B 411
PHE B 261
ILE B 254
GLY B 257
 None
 1.04A 5fsaB-3o0rB:
undetectable		 5fsaB-3o0rB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		4 / 6 TYR B 353
LEU B  26
PHE B  27
LEU B  68
 None
 1.15A 5tl8A-3o0rB:
0.0		 5tl8A-3o0rB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B
(Pseudomonas
aeruginosa) 		3 / 3 HIS B 207
HIS B 258
HIS B 259
 FE  B 803 (-3.3A)
FE  B 803 (-3.3A)
FE  B 803 (-3.3A)
 0.68A 6giqa-3o0rB:
29.4		 6giqa-3o0rB:
23.66