SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 200
GLU A 177
TYR A 197
GLN A 196
 None
PO4  A   1 (-3.4A)
None
None
 0.96A 3w9tB-3o0tA:
undetectable		 3w9tB-3o0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 200
GLU A 177
TYR A 197
GLN A 196
 None
PO4  A   1 (-3.4A)
None
None
 1.03A 3w9tD-3o0tA:
undetectable		 3w9tD-3o0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 200
GLU A 177
TYR A 197
GLN A 196
 None
PO4  A   1 (-3.4A)
None
None
 1.06A 3w9tE-3o0tA:
undetectable		 3w9tE-3o0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 242
LEU A 252
THR A 260
LEU A 275
LEU A 272
 None
 0.91A 4z91A-3o0tA:
undetectable
4z91B-3o0tA:
undetectable
4z91C-3o0tA:
undetectable
4z91D-3o0tA:
undetectable
4z91E-3o0tA:
undetectable		 4z91A-3o0tA:
22.32
4z91B-3o0tA:
22.32
4z91C-3o0tA:
22.32
4z91D-3o0tA:
22.32
4z91E-3o0tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 272
LEU A 242
LEU A 252
THR A 260
LEU A 275
 None
 0.95A 4z91A-3o0tA:
undetectable
4z91B-3o0tA:
undetectable
4z91C-3o0tA:
undetectable
4z91D-3o0tA:
undetectable
4z91E-3o0tA:
undetectable		 4z91A-3o0tA:
22.32
4z91B-3o0tA:
22.32
4z91C-3o0tA:
22.32
4z91D-3o0tA:
22.32
4z91E-3o0tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3o0t SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A  -1
ASP A  90
ARG A 240
 EDO  A   5 ( 4.8A)
EDO  A   5 (-3.3A)
EDO  A   5 (-3.3A)
 0.90A 5jwaA-3o0tA:
undetectable
5jwaH-3o0tA:
undetectable		 5jwaA-3o0tA:
13.65
5jwaH-3o0tA:
13.65