SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.89A 1fm6A-3o10A:
undetectable		 1fm6A-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.93A 1fm9A-3o10A:
undetectable		 1fm9A-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.95A 1k74A-3o10A:
undetectable		 1k74A-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.92A 1xdkE-3o10A:
undetectable		 1xdkE-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.92A 1xiuA-3o10A:
undetectable		 1xiuA-3o10A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.84A 1xlsA-3o10A:
undetectable		 1xlsA-3o10A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.84A 1xlsB-3o10A:
undetectable		 1xlsB-3o10A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.84A 1xlsC-3o10A:
undetectable		 1xlsC-3o10A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.84A 1xlsD-3o10A:
undetectable		 1xlsD-3o10A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.76A 3h0aA-3o10A:
undetectable		 3h0aA-3o10A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3o10 SACSIN
(Homo
sapiens) 		4 / 6 ILE A4567
ALA A4484
LEU A4485
ILE A4509
 None
 0.65A 5mvmB-3o10A:
2.1
5mvmC-3o10A:
2.9		 5mvmB-3o10A:
20.00
5mvmC-3o10A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.88A 5uanA-3o10A:
undetectable		 5uanA-3o10A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3o10 SACSIN
(Homo
sapiens) 		5 / 12 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.87A 6a5zL-3o10A:
undetectable		 6a5zL-3o10A:
18.71