SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 ILE A 104
THR A  44
ALA A  43
VAL A  28
TYR A  49
 None
None
NIO  A 300 ( 3.9A)
None
None
 1.32A 2gl0B-3o14A:
undetectable
2gl0C-3o14A:
undetectable		 2gl0B-3o14A:
22.89
2gl0C-3o14A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 ILE A 104
HIS A  60
HIS A  58
HIS A  94
 None
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
 0.85A 3ljgA-3o14A:
undetectable		 3ljgA-3o14A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 ILE A 104
HIS A  94
HIS A  60
HIS A  58
 None
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
 1.02A 3ljgA-3o14A:
undetectable		 3ljgA-3o14A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 PRO A  51
GLY A  71
VAL A  72
SER A  98
 None
 0.94A 4a3uB-3o14A:
undetectable		 4a3uB-3o14A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 SER A  23
GLU A  64
GLU A  76
 NIO  A 300 ( 4.4A)
ZN  A 250 (-1.8A)
None
 0.67A 4ymgB-3o14A:
undetectable		 4ymgB-3o14A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 164
ARG A 144
LYS A 210
GLU A 167
LEU A 214
 None
 0.71A 5c0oH-3o14A:
undetectable		 5c0oH-3o14A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ASP A 112
TYR A  85
ASP A 142
HIS A 140
GLU A 143
 None
 1.21A 5igzA-3o14A:
0.3		 5igzA-3o14A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 ILE A 104
HIS A  60
HIS A  58
HIS A  94
 None
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
ZN  A 250 (-3.3A)
 0.79A 5n5kA-3o14A:
undetectable		 5n5kA-3o14A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 GLU A 124
LEU A 127
LYS A 206
LEU A 171
 None
 1.03A 5yvnA-3o14A:
undetectable		 5yvnA-3o14A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3o14 ANTI-ECFSIGMA
FACTOR, CHRR
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 GLU A   2
GLY A  37
GLY A  38
ILE A  36
ALA A  41
 None
 1.12A 6e5zA-3o14A:
undetectable		 6e5zA-3o14A:
23.50