SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 11 GLY A 119
ALA A 120
VAL A 357
PRO A 379
VAL A 378
 None
 0.95A 1hxwB-3o21A:
undetectable		 1hxwB-3o21A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 ILE A 178
ILE A 198
LEU A 202
VAL A 205
ILE A 227
 None
 1.02A 1oipA-3o21A:
undetectable		 1oipA-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 VAL A  27
GLY A   9
TYR A  71
SER A  64
HIS A  46
 None
 1.16A 2cl5A-3o21A:
5.2		 2cl5A-3o21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 GLY A 119
ALA A 120
VAL A 357
PRO A 379
VAL A 378
 None
 0.93A 2q5kB-3o21A:
undetectable		 2q5kB-3o21A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 ILE A  73
TYR A  77
VAL A  97
CYH A  89
 None
 1.02A 2xz5A-3o21A:
undetectable
2xz5C-3o21A:
undetectable		 2xz5A-3o21A:
20.21
2xz5C-3o21A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 ILE A  73
TYR A  77
VAL A  97
CYH A  89
 None
 1.02A 2xz5C-3o21A:
undetectable
2xz5D-3o21A:
undetectable		 2xz5C-3o21A:
20.21
2xz5D-3o21A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 219
ILE A 198
ILE A 177
VAL A 205
VAL A 232
 None
 1.06A 2ygoA-3o21A:
undetectable		 2ygoA-3o21A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 VAL A  27
GLY A   9
TYR A  71
SER A  64
HIS A  46
 None
 0.96A 2zthA-3o21A:
6.0		 2zthA-3o21A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 4 ILE A 286
GLN A  28
ILE A   8
LEU A 262
 None
 1.27A 3dzyD-3o21A:
undetectable		 3dzyD-3o21A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 PRO A 115
LEU A 281
ILE A 342
GLN A 336
ILE A 244
 None
None
None
NAG  A 390 ( 3.9A)
None
 1.35A 4a79A-3o21A:
undetectable		 4a79A-3o21A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 PRO A 115
LEU A 281
ILE A 342
GLN A 336
ILE A 244
 None
None
None
NAG  A 390 ( 3.9A)
None
 1.35A 4a79B-3o21A:
undetectable		 4a79B-3o21A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 5 ASN A   4
ARG A 297
HIS A  42
LEU A  43
 None
 1.25A 4g5jA-3o21A:
undetectable		 4g5jA-3o21A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 GLY A 323
GLN A 322
SER A  95
PHE A 109
 None
 0.86A 4wryA-3o21A:
undetectable		 4wryA-3o21A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 GLY A 323
GLN A 322
SER A  95
PHE A 109
 None
 0.85A 4wrzA-3o21A:
undetectable		 4wrzA-3o21A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 7 GLY A 323
GLN A 322
SER A  95
PHE A 109
 None
 0.95A 4ws0A-3o21A:
2.4		 4ws0A-3o21A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 8 GLY A 323
GLN A 322
SER A  95
PHE A 109
 None
 0.97A 4ws1A-3o21A:
2.4		 4ws1A-3o21A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 6 GLY A  69
SER A   7
VAL A  70
HIS A  46
 None
 1.10A 5ewuA-3o21A:
2.9		 5ewuA-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 6 GLY A  69
SER A   7
VAL A  70
HIS A  46
 None
 1.06A 5ewuB-3o21A:
3.0		 5ewuB-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 PHE A 242
HIS A 216
LEU A 229
LEU A 124
TYR A 128
 None
NAG  A 391 ( 4.8A)
None
None
None
 1.48A 5ji0D-3o21A:
undetectable		 5ji0D-3o21A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		4 / 7 TYR A  45
GLN A  65
ASP A  48
HIS A  49
 None
 1.30A 5ov9B-3o21A:
2.8		 5ov9B-3o21A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3o21 GLUTAMATE RECEPTOR 3
(Rattus
norvegicus) 		5 / 12 LEU A 219
ILE A 227
GLY A 223
ILE A 191
ILE A 198
 None
 1.02A 6emuA-3o21A:
undetectable		 6emuA-3o21A:
19.02