SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		3 / 3 ASP B 103
PHE B  36
ARG B  34
 None
 0.84A 2a3aA-3o2sB:
undetectable		 2a3aA-3o2sB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		5 / 12 LEU B 154
ILE B 155
CYH B 159
VAL B 137
SER B 183
 None
 1.18A 2bxeB-3o2sB:
undetectable		 2bxeB-3o2sB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		5 / 12 LEU B  85
ARG B  94
PRO B  95
GLN B  16
VAL B  42
 None
 1.32A 4b3aA-3o2sB:
undetectable		 4b3aA-3o2sB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		4 / 8 PHE B  98
GLU B  96
SER B  35
ARG B 126
 None
 1.23A 4d32A-3o2sB:
undetectable
4d32B-3o2sB:
undetectable		 4d32A-3o2sB:
17.33
4d32B-3o2sB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		5 / 12 ASN B  24
ALA B 152
ILE B 141
ALA B 148
ILE B 155
 None
 0.98A 4o2bD-3o2sB:
undetectable		 4o2bD-3o2sB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens) 		4 / 7 PHE B  98
GLU B  96
SER B  35
ARG B 126
 None
 1.27A 6av6C-3o2sB:
undetectable
6av6D-3o2sB:
undetectable		 6av6C-3o2sB:
13.55
6av6D-3o2sB:
13.55