SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1041
VAL A1097
LEU A1129
LEU A1084
LEU A1119
 None
 1.13A 1mx1E-3o2uA:
undetectable		 1mx1E-3o2uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1155
ASN A1150
PRO A1148
ALA A1154
 None
 1.40A 2ejgB-3o2uA:
undetectable		 2ejgB-3o2uA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		5 / 10 ILE A1108
ASN A1083
LEU A1139
LEU A1136
VAL A1066
 None
 1.17A 3o02A-3o2uA:
undetectable
3o02B-3o2uA:
undetectable		 3o02A-3o2uA:
19.93
3o02B-3o2uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		5 / 11 ASP A1035
VAL A1049
ILE A1133
ILE A1132
PHE A1086
 None
GOL  A3968 ( 4.8A)
None
None
None
 1.26A 5hw8B-3o2uA:
undetectable		 5hw8B-3o2uA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1017
PRO A1023
GLN A1022
 None
 0.88A 6jnhA-3o2uA:
undetectable		 6jnhA-3o2uA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3o2u NEDD8-CONJUGATING
ENZYME UBC12
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1017
PRO A1023
GLN A1022
 None
 0.91A 6jogA-3o2uA:
undetectable		 6jogA-3o2uA:
18.14