SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A 107
GLY A 130
GLY A 131
GLY A 132
ASP A 180
 3O3  A   1 (-3.8A)
None
None
None
None
 1.20A 1qzzA-3o31A:
15.1		 1qzzA-3o31A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 GLY A 173
ASP A 172
ASN A 175
 None
 0.63A 1vq1A-3o31A:
12.0		 1vq1A-3o31A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 LEU A  57
ILE A  10
ILE A  42
ALA A  43
 None
 0.79A 2i30A-3o31A:
undetectable		 2i30A-3o31A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A 108
MET A 147
MET A 193
LEU A 141
 None
 1.40A 2oz7A-3o31A:
undetectable		 2oz7A-3o31A:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		11 / 12 GLN A  81
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ILE A 158
ALA A 195
LEU A 197
ARG A 203
VAL A 204
 3O3  A   1 ( 4.8A)
BR  A 298 ( 4.8A)
None
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
None
 0.36A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		9 / 12 MET A  78
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ALA A 195
LEU A 197
VAL A 204
 None
BR  A 298 ( 4.8A)
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
 1.03A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		6 / 6 TYR A 107
GLY A 132
THR A 137
GLU A 153
GLU A 155
GLU A 181
 3O3  A   1 (-3.8A)
None
BR  A 298 (-4.0A)
None
None
None
 0.58A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		8 / 12 MET A  78
ILE A 129
ILE A 154
GLU A 155
ILE A 158
LEU A 197
ARG A 203
VAL A 204
 None
None
None
None
None
3O3  A   1 (-4.2A)
None
None
 0.93A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		11 / 12 TYR A 107
PHE A 128
ILE A 129
VAL A 152
ILE A 154
GLU A 155
ILE A 158
LEU A 197
ARG A 203
VAL A 204
ARG A 221
 3O3  A   1 (-3.8A)
BR  A 298 ( 4.8A)
None
None
None
None
None
3O3  A   1 (-4.2A)
None
None
3O3  A   1 (-4.0A)
 0.44A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		7 / 7 GLN A  81
GLY A 130
GLY A 132
THR A 137
GLU A 153
GLU A 181
ALA A 195
 3O3  A   1 ( 4.8A)
None
None
BR  A 298 (-4.0A)
None
None
3O3  A   1 (-3.5A)
 0.30A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 ASN A 256
ARG A 221
ASN A 113
GLU A 114
 3O3  A   1 (-3.4A)
3O3  A   1 (-4.0A)
None
None
 1.36A 3galB-3o31A:
undetectable		 3galB-3o31A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 LEU A 134
PRO A 135
LEU A 136
ARG A  99
 None
 1.13A 3hcoB-3o31A:
3.5		 3hcoB-3o31A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 THR A 182
PHE A 205
ASN A 207
ALA A 195
GLY A 130
 None
None
None
3O3  A   1 (-3.5A)
None
 1.18A 3v3oA-3o31A:
4.4		 3v3oA-3o31A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 GLY A 130
GLY A 132
ILE A 154
ASP A 180
ARG A 221
ALA A 198
 None
None
None
None
3O3  A   1 (-4.0A)
None
 1.27A 4iv8A-3o31A:
12.2		 4iv8A-3o31A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		6 / 12 GLY A 130
GLY A 132
ILE A 154
ASP A 180
ARG A 221
ALA A 198
 None
None
None
None
3O3  A   1 (-4.0A)
None
 1.30A 4iv8B-3o31A:
12.2		 4iv8B-3o31A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A 194
ALA A 196
PHE A 128
 None
3O3  A   1 (-3.4A)
BR  A 298 ( 4.8A)
 0.93A 4olbA-3o31A:
undetectable		 4olbA-3o31A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A 194
ALA A 196
PHE A 128
 None
3O3  A   1 (-3.4A)
BR  A 298 ( 4.8A)
 0.91A 4w5nA-3o31A:
undetectable		 4w5nA-3o31A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 VAL A 248
LEU A 136
LEU A 111
ASN A 113
ALA A 196
 None
None
None
None
3O3  A   1 (-3.4A)
 1.17A 4x1kA-3o31A:
undetectable
4x1kB-3o31A:
undetectable		 4x1kA-3o31A:
21.63
4x1kB-3o31A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 TYR A  73
ILE A 229
ILE A  39
ALA A  43
GLU A  40
 3O3  A   1 (-4.4A)
None
None
None
None
 1.40A 5cf9B-3o31A:
undetectable		 5cf9B-3o31A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 VAL A 149
HIS A 143
VAL A 171
 None
 0.65A 5jmnC-3o31A:
undetectable		 5jmnC-3o31A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3o31 THERMONICOTIANAMINE
SYNTHASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 130
GLY A 132
ILE A 154
GLU A 155
ALA A 198
 None
 0.58A 5x7fA-3o31A:
12.0		 5x7fA-3o31A:
24.03