SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 GLY B 142
LEU B 147
ILE B  42
ILE B 137
HIS B 123
 None
 1.21A 1kyvA-3o3mB:
3.5
1kyvE-3o3mB:
3.5		 1kyvA-3o3mB:
20.11
1kyvE-3o3mB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 ILE B 137
HIS B 123
GLY B 142
LEU B 147
ILE B  42
 None
 1.20A 1kyvB-3o3mB:
3.5
1kyvC-3o3mB:
3.5		 1kyvB-3o3mB:
20.11
1kyvC-3o3mB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 ILE B 237
GLY B 236
PRO B 327
ARG B 301
 SF4  B 386 ( 4.3A)
None
SF4  B 386 ( 4.5A)
None
 0.97A 1oniG-3o3mB:
undetectable
1oniI-3o3mB:
undetectable		 1oniG-3o3mB:
18.72
1oniI-3o3mB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.39A 1qkuA-3o3mB:
undetectable		 1qkuA-3o3mB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.39A 1qkuB-3o3mB:
undetectable		 1qkuB-3o3mB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.40A 1qkuC-3o3mB:
undetectable		 1qkuC-3o3mB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 LEU B 260
LEU B 233
VAL B 255
ARG B 193
PHE B 319
 None
 1.25A 1s9pB-3o3mB:
undetectable		 1s9pB-3o3mB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 11 ILE B  43
VAL B  51
GLY B  52
CYH B  33
LEU B  49
 None
 1.28A 2bxeA-3o3mB:
undetectable		 2bxeA-3o3mB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.45A 2ocfA-3o3mB:
undetectable		 2ocfA-3o3mB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		4 / 6 MET B 322
PRO B 327
SER B 292
MET B  98
 None
SF4  B 386 ( 4.5A)
None
None
 1.36A 2qd3B-3o3mB:
1.9		 2qd3B-3o3mB:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 GLY B  55
TYR B  81
SER B  77
 None
 0.72A 2xatA-3o3mB:
0.4		 2xatA-3o3mB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.34A 3erdB-3o3mB:
undetectable		 3erdB-3o3mB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 ALA B  30
GLY B  32
VAL B  93
GLY B  92
VAL B  19
 None
 0.77A 3f8wA-3o3mB:
undetectable		 3f8wA-3o3mB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 ALA B  30
GLY B  32
VAL B  93
GLY B  92
VAL B  19
 None
 0.81A 3f8wC-3o3mB:
undetectable		 3f8wC-3o3mB:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 SER B  73
ASP B 352
ASN B 358
 None
 1.02A 3lsfB-3o3mB:
undetectable
3lsfE-3o3mB:
undetectable		 3lsfB-3o3mB:
19.90
3lsfE-3o3mB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 ASP B 352
ASN B 358
SER B  73
 None
 1.02A 3lsfB-3o3mB:
undetectable
3lsfE-3o3mB:
undetectable		 3lsfB-3o3mB:
19.90
3lsfE-3o3mB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.45A 3uudB-3o3mB:
undetectable		 3uudB-3o3mB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 SER B  73
GLN B  57
LEU B 238
ASP B 240
 None
 1.17A 4hxyB-3o3mB:
undetectable		 4hxyB-3o3mB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 MET B 322
PRO B 327
SER B 292
MET B  98
 None
SF4  B 386 ( 4.5A)
None
None
 1.49A 4kmmA-3o3mB:
undetectable		 4kmmA-3o3mB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		4 / 5 MET B 322
LEU B 238
PRO B 327
SER B 292
 None
None
SF4  B 386 ( 4.5A)
None
 1.42A 4kmmB-3o3mB:
undetectable		 4kmmB-3o3mB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.24A 4xi3D-3o3mB:
undetectable		 4xi3D-3o3mB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 9 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.44A 5dx3B-3o3mB:
0.3		 5dx3B-3o3mB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 7 ASN B  16
VAL B  19
ALA B  30
GLY B  32
VAL B  51
 None
 1.16A 5fpdB-3o3mB:
undetectable		 5fpdB-3o3mB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 9 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.45A 5wgqA-3o3mB:
undetectable		 5wgqA-3o3mB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE
(Clostridioides
difficile) 		5 / 10 GLU B  41
LEU B 281
ARG B 171
MET B  98
LEU B 121
 None
 1.41A 5wgqB-3o3mB:
undetectable		 5wgqB-3o3mB:
12.37