SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 GLU A  95
PRO A 107
MET A 104
GLY A  97
 None
 1.29A 2hs1B-3o3oA:
undetectable		 2hs1B-3o3oA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 MET A 104
TYR A  19
PRO A 107
VAL A  32
ALA A  58
 None
 1.20A 2x2nC-3o3oA:
undetectable		 2x2nC-3o3oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 GLY A 211
SER A 207
MET A 209
SER A 288
LEU A 330
 None
 1.35A 3bxoA-3o3oA:
undetectable		 3bxoA-3o3oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 11 VAL A 317
ASN A 143
THR A 312
ALA A 307
GLN A 150
 None
 1.47A 3kp5A-3o3oA:
undetectable		 3kp5A-3o3oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 ASP A 374
SER A 345
ARG A  88
 None
 0.90A 3loqA-3o3oA:
undetectable		 3loqA-3o3oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 LEU A 200
SER A 207
THR A 247
ASP A 243
 None
 1.00A 4drjB-3o3oA:
undetectable		 4drjB-3o3oA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 6 LEU A 193
GLU A 232
VAL A  10
ALA A   7
 None
 0.98A 4nkvC-3o3oA:
undetectable		 4nkvC-3o3oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 6 LEU A 193
GLU A 232
VAL A  10
ALA A   7
 None
 0.90A 4nkxA-3o3oA:
undetectable		 4nkxA-3o3oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 6 ASP A  48
GLU A  45
ASN A  50
ARG A  30
 None
 1.22A 4ntxA-3o3oA:
undetectable
4ntxC-3o3oA:
undetectable		 4ntxA-3o3oA:
22.62
4ntxC-3o3oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 6 GLU A 229
ASP A  48
ASN A  50
ARG A  30
 None
 1.07A 4ntxA-3o3oA:
undetectable
4ntxC-3o3oA:
undetectable		 4ntxA-3o3oA:
22.62
4ntxC-3o3oA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		6 / 12 VAL A  38
LEU A 214
ALA A 293
MET A 313
ASN A 315
GLY A 264
 None
None
None
None
2RH  A 410 (-3.5A)
None
 1.43A 4qckA-3o3oA:
undetectable		 4qckA-3o3oA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		5 / 12 VAL A  38
MET A 218
ALA A 293
MET A 313
ASN A 315
 None
2RH  A 410 ( 4.9A)
None
None
2RH  A 410 (-3.5A)
 1.45A 4qdcA-3o3oA:
undetectable		 4qdcA-3o3oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 8 ASN A 210
TRP A 268
PHE A 215
THR A 277
 None
 1.04A 5hqaA-3o3oA:
2.4		 5hqaA-3o3oA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 GLY A 211
THR A 286
ASN A 284
 None
 0.65A 5odiG-3o3oA:
5.2		 5odiG-3o3oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		3 / 3 TYR A 340
ALA A 361
TYR A 368
 None
 0.84A 5uunB-3o3oA:
undetectable		 5uunB-3o3oA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE
(Clostridioides
difficile) 		4 / 7 ASN A  90
ALA A  87
GLU A  75
LEU A  93
 None
 0.77A 6ci6A-3o3oA:
1.2		 6ci6A-3o3oA:
15.47