SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 VAL A 149
GLY A 148
ALA A 208
GLU A 230
ILE A 233
 None
None
None
GDD  A 340 (-3.9A)
None
 1.15A 1kxhA-3o3pA:
undetectable		 1kxhA-3o3pA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.06A 1mj2A-3o3pA:
undetectable		 1mj2A-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.08A 1mjoA-3o3pA:
undetectable		 1mjoA-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLU A 210
ARG A 254
ALA A  46
LEU A  48
PRO A  49
 None
MG  A 339 ( 4.7A)
None
None
GDD  A 340 (-4.8A)
 1.07A 1mjoB-3o3pA:
undetectable		 1mjoB-3o3pA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 PRO A  49
GLY A 226
GLY A 116
VAL A 323
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
 0.88A 1nv8A-3o3pA:
undetectable		 1nv8A-3o3pA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		6 / 12 PRO A  49
GLY A 226
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
None
 1.09A 1sg9B-3o3pA:
undetectable		 1sg9B-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 PRO A  49
GLY A 116
VAL A 323
GLU A 321
ALA A 112
 GDD  A 340 (-4.8A)
None
None
None
None
 1.03A 1sg9C-3o3pA:
undetectable		 1sg9C-3o3pA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		3 / 3 SER A 101
ASP A 117
ASP A 111
 None
 0.77A 2plwA-3o3pA:
undetectable		 2plwA-3o3pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		4 / 6 ASP A 214
ARG A 160
VAL A 237
ILE A 221
 None
 1.23A 2yfbB-3o3pA:
undetectable		 2yfbB-3o3pA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A  58
ASP A 137
ALA A 136
ASP A  62
ILE A  60
 None
MG  A 339 ( 2.5A)
GDD  A 340 (-3.6A)
None
None
 1.32A 3id5B-3o3pA:
undetectable		 3id5B-3o3pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A  58
ASP A 137
ALA A 136
ASP A  62
ILE A  60
 None
MG  A 339 ( 2.5A)
GDD  A 340 (-3.6A)
None
None
 1.31A 3id5F-3o3pA:
undetectable		 3id5F-3o3pA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 PRO A 206
ARG A 254
GLY A 180
GLY A 209
ALA A 208
 None
MG  A 339 ( 4.7A)
None
GDD  A 340 (-3.5A)
None
 1.36A 3pp7B-3o3pA:
5.0		 3pp7B-3o3pA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 ASP A 137
ASP A 135
GLY A 209
GLY A 116
PHE A 211
 MG  A 339 ( 2.5A)
GDD  A 340 (-3.2A)
GDD  A 340 (-3.5A)
None
None
 0.83A 3prsA-3o3pA:
undetectable		 3prsA-3o3pA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 7 ILE A  60
ILE A  61
VAL A  79
LEU A  48
SER A  50
 None
 0.95A 3r9vA-3o3pA:
undetectable
3r9vB-3o3pA:
undetectable		 3r9vA-3o3pA:
20.20
3r9vB-3o3pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 VAL A 319
ARG A 121
ALA A 228
THR A 225
ASP A 117
 None
 0.97A 3sugA-3o3pA:
undetectable		 3sugA-3o3pA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.19A 4c5lA-3o3pA:
undetectable		 4c5lA-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5lB-3o3pA:
undetectable		 4c5lB-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.20A 4c5lC-3o3pA:
undetectable		 4c5lC-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5lD-3o3pA:
undetectable		 4c5lD-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.21A 4c5nB-3o3pA:
undetectable		 4c5nB-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.22A 4c5nD-3o3pA:
undetectable		 4c5nD-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 11 THR A 126
ALA A 122
LEU A 105
SER A  45
ILE A  77
 None
 1.41A 4claA-3o3pA:
undetectable		 4claA-3o3pA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 12 ALA A  66
LEU A 150
VAL A 149
LEU A 132
ILE A  74
 None
 1.05A 4km2B-3o3pA:
undetectable		 4km2B-3o3pA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		4 / 6 ARG A 278
ALA A 274
ASP A 236
LEU A 322
 None
 1.14A 4ot2A-3o3pA:
undetectable		 4ot2A-3o3pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		4 / 6 VAL A 162
GLN A 248
VAL A 249
TYR A  23
 None
 1.02A 5i8fA-3o3pA:
undetectable		 5i8fA-3o3pA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		4 / 6 GLU A 282
ARG A 284
LEU A 285
ARG A 277
 None
None
None
CL  A 337 (-4.1A)
 0.94A 5l6eA-3o3pA:
undetectable
5l6eB-3o3pA:
undetectable		 5l6eA-3o3pA:
19.30
5l6eB-3o3pA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		3 / 3 GLY A 182
VAL A 271
MET A 267
 None
None
GDD  A 340 (-3.4A)
 0.60A 5ycpA-3o3pA:
undetectable		 5ycpA-3o3pA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 9 VAL A 153
LEU A 154
GLY A  41
LEU A  40
VAL A  44
 None
 1.15A 6czmD-3o3pA:
undetectable
6czmE-3o3pA:
undetectable		 6czmD-3o3pA:
23.83
6czmE-3o3pA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Rubrobacter
xylanophilus) 		5 / 10 VAL A  79
LEU A  48
SER A  50
GLY A  96
GLY A  87
 None
 1.06A 6eu9B-3o3pA:
undetectable		 6eu9B-3o3pA:
12.37