SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TRP A  80
HIS A 111
GLU A 186
TYR A 210
SER A 211
 None
NAP  A 317 (-4.3A)
None
NAP  A 317 (-3.3A)
NAP  A 317 (-3.4A)
 0.29A 1s2aA-3o3rA:
44.5		 1s2aA-3o3rA:
45.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 6 ARG A 256
GLN A 193
GLU A 194
ILE A 197
 None
 1.07A 2fcnA-3o3rA:
undetectable
2fcnB-3o3rA:
undetectable		 2fcnA-3o3rA:
13.62
2fcnB-3o3rA:
13.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 5 TRP A  21
VAL A  48
TYR A  49
HIS A 111
 None
None
NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
 0.33A 2ineA-3o3rA:
50.1		 2ineA-3o3rA:
68.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 5 TRP A  21
VAL A  48
TYR A  49
HIS A 111
 None
None
NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
 0.35A 2isfA-3o3rA:
49.8		 2isfA-3o3rA:
69.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 GLU A  52
LEU A 109
ASP A 106
VAL A 154
ALA A 156
 None
 1.22A 2kceA-3o3rA:
undetectable		 2kceA-3o3rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 8 VAL A 265
GLN A  27
ILE A  75
GLY A  19
 NAP  A 317 (-3.8A)
None
None
NAP  A 317 (-3.2A)
 0.86A 3hjoA-3o3rA:
undetectable		 3hjoA-3o3rA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TYR A  49
TRP A  80
HIS A 111
ASN A 161
TYR A 210
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
 0.25A 3r43A-3o3rA:
44.2		 3r43A-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 10 TYR A  49
HIS A 111
ASN A 161
TYR A 210
PRO A 311
 NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
None
 0.63A 3r58A-3o3rA:
43.2		 3r58A-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TYR A  49
TRP A  80
HIS A 111
ASN A 161
TYR A 210
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
 0.27A 3r6iA-3o3rA:
43.0		 3r6iA-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 9 TYR A  49
HIS A 111
ASN A 161
TYR A 210
PRO A 311
 NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
None
 0.67A 3r8gA-3o3rA:
43.1		 3r8gA-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TYR A  49
HIS A 111
ASN A 161
TYR A 210
PRO A 311
 NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
None
 0.71A 3r94A-3o3rA:
42.9		 3r94A-3o3rA:
45.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 6 ALA A  31
ILE A 270
LEU A  18
GLU A  30
ALA A  58
 None
 1.25A 3r9sA-3o3rA:
2.0		 3r9sA-3o3rA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 10 TRP A  21
VAL A  48
TYR A  49
HIS A 111
LEU A 301
 None
None
NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
None
 0.60A 3rx3A-3o3rA:
50.3		 3rx3A-3o3rA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		6 / 12 TYR A  49
TRP A  80
HIS A 111
ASN A 161
SER A 211
PRO A 311
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.4A)
None
 0.67A 3ug8A-3o3rA:
43.0		 3ug8A-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		6 / 12 TYR A  49
TRP A  80
HIS A 111
ASN A 161
TYR A 210
SER A 211
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
NAP  A 317 (-3.4A)
 0.30A 3ug8A-3o3rA:
43.0		 3ug8A-3o3rA:
45.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 8 TRP A  21
VAL A  48
TRP A  80
HIS A 111
PRO A 219
 None
None
None
NAP  A 317 (-4.3A)
None
 0.58A 3v35A-3o3rA:
50.3		 3v35A-3o3rA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 8 VAL A  48
TYR A  49
TRP A  80
HIS A 111
 None
NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
 0.16A 4jq1B-3o3rA:
45.1		 4jq1B-3o3rA:
46.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 8 VAL A  48
TYR A  49
TRP A  80
HIS A 111
 None
NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
 0.25A 4jtrA-3o3rA:
45.3		 4jtrA-3o3rA:
46.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 6 VAL A  48
TYR A  49
TRP A  80
HIS A 111
 None
NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
 0.29A 4jtrB-3o3rA:
45.3		 4jtrB-3o3rA:
46.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 10 TRP A  21
VAL A  48
TYR A  49
HIS A 111
LEU A 301
 None
None
NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
None
 0.61A 4wevX-3o3rA:
51.7		 4wevX-3o3rA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 9 TYR A  49
TRP A  80
HIS A 111
ASN A 161
TYR A 210
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
NAP  A 317 (-3.1A)
NAP  A 317 (-3.3A)
 0.21A 4yvvA-3o3rA:
45.2		 4yvvA-3o3rA:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TYR A  49
TRP A  80
HIS A 111
LEU A 116
ASN A 161
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
None
NAP  A 317 (-3.1A)
 0.22A 4yvxA-3o3rA:
44.7		 4yvxA-3o3rA:
45.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 12 TYR A  49
TRP A  80
HIS A 111
LEU A 116
ASN A 161
 NAP  A 317 (-4.9A)
None
NAP  A 317 (-4.3A)
None
NAP  A 317 (-3.1A)
 0.20A 4yvxB-3o3rA:
44.7		 4yvxB-3o3rA:
45.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		4 / 8 ILE A  59
VAL A  55
SER A  77
CYH A  45
 None
 0.96A 5dqyA-3o3rA:
0.8		 5dqyA-3o3rA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		3 / 3 HIS A 188
SER A 211
ARG A 218
 None
NAP  A 317 (-3.4A)
None
 0.85A 5u63A-3o3rA:
undetectable		 5u63A-3o3rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7
(Rattus
norvegicus) 		5 / 9 LEU A 171
ARG A 169
PHE A 138
VAL A 159
ILE A 167
 None
 1.30A 6ef6A-3o3rA:
undetectable		 6ef6A-3o3rA:
20.11