SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLU N 130
GLU N 131
LEU N 135
MET N 224
LEU N 115
 None
 1.47A 1a29A-3o3uN:
undetectable		 1a29A-3o3uN:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL N   8
VAL N  50
ILE N  60
ASN N 267
 None
 0.94A 1e06A-3o3uN:
undetectable		 1e06A-3o3uN:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU N 192
LEU N 195
ILE N 161
GLU N 153
LEU N 151
 None
None
None
MLR  N2001 (-3.2A)
None
 1.24A 1wopA-3o3uN:
undetectable		 1wopA-3o3uN:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU N 262
GLY N 289
ALA N 109
ILE N 108
 None
 0.82A 2aohB-3o3uN:
undetectable		 2aohB-3o3uN:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ALA N 188
LEU N 192
ALA N 346
THR N 345
 None
 0.92A 3b6hA-3o3uN:
undetectable		 3b6hA-3o3uN:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE N 258
ALA N 162
LEU N 247
PRO N 159
 None
 0.99A 3bgdA-3o3uN:
undetectable		 3bgdA-3o3uN:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL N 110
GLY N 300
PRO N 229
LYS N 305
 None
 0.66A 3bjwC-3o3uN:
undetectable		 3bjwC-3o3uN:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL N 110
GLY N 300
PRO N 229
LYS N 305
 None
 0.88A 3bjwA-3o3uN:
undetectable		 3bjwA-3o3uN:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL N 343
GLY N 187
ALA N 188
LEU N 192
LEU N 160
 None
 1.04A 3hs6A-3o3uN:
undetectable		 3hs6A-3o3uN:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		12 / 12 ASP N  14
LYS N  15
LYS N  42
GLU N  44
GLU N  45
ALA N  63
ASP N  65
ARG N  66
GLU N 111
PRO N 154
TRP N 230
TYR N 341
 MLR  N2001 (-3.0A)
MLR  N2001 (-2.8A)
None
MLR  N2001 (-3.6A)
MLR  N2001 (-4.1A)
MLR  N2001 (-3.3A)
MLR  N2001 (-2.9A)
MLR  N2001 (-3.9A)
MLR  N2001 (-2.9A)
MLR  N2001 (-3.5A)
MLR  N2001 (-4.4A)
MLR  N2001 (-4.4A)
 0.24A 3jyrA-3o3uN:
63.3		 3jyrA-3o3uN:
71.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		7 / 7 ASN N  12
TRP N  62
GLU N 153
TYR N 155
MET N 330
TRP N 340
ARG N 344
 MLR  N2001 ( 4.7A)
MLR  N2001 (-4.3A)
MLR  N2001 (-3.2A)
MLR  N2001 (-3.8A)
MLR  N2001 ( 4.3A)
MLR  N2001 (-3.8A)
None
 0.18A 3jyrA-3o3uN:
63.3		 3jyrA-3o3uN:
71.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL N 196
LEU N 160
GLY N 187
ALA N 188
LEU N 361
 None
 0.98A 3n8yB-3o3uN:
undetectable		 3n8yB-3o3uN:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ILE N 161
GLN N 365
ALA N 362
LEU N 361
ALA N 162
 None
 1.10A 3ozvB-3o3uN:
undetectable		 3ozvB-3o3uN:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE N 156
GLY N 300
LEU N 299
GLU N 111
ALA N 231
 None
None
None
MLR  N2001 (-2.9A)
None
 0.84A 3tbgB-3o3uN:
undetectable		 3tbgB-3o3uN:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE N 156
GLY N 300
LEU N 299
GLU N 111
ALA N 231
 None
None
None
MLR  N2001 (-2.9A)
None
 0.83A 3tbgD-3o3uN:
undetectable		 3tbgD-3o3uN:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA N 231
TYR N  17
TYR N 210
ASN N 234
GLY N 228
 None
 1.35A 3vwqA-3o3uN:
undetectable		 3vwqA-3o3uN:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLY N1082
VAL N1078
PRO N1080
ASN N1081
 None
 0.85A 4forA-3o3uN:
4.9		 4forA-3o3uN:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN N 267
ALA N  51
GLY N  56
ASP N  14
 None
None
None
MLR  N2001 (-3.0A)
 0.95A 4n48A-3o3uN:
undetectable		 4n48A-3o3uN:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA N 264
ALA N 105
LEU N 103
LEU N 262
VAL N 261
 None
 1.14A 4or0B-3o3uN:
undetectable		 4or0B-3o3uN:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA N 342
ALA N 338
GLY N 166
ALA N 188
PHE N 169
VAL N 181
 None
 1.40A 5w4zA-3o3uN:
undetectable		 5w4zA-3o3uN:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA N 342
ALA N 338
GLY N 166
ALA N 188
PHE N 169
VAL N 181
 None
 1.42A 5w4zB-3o3uN:
undetectable		 5w4zB-3o3uN:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR N 155
ASN N 227
LEU N 113
 MLR  N2001 (-3.8A)
None
None
 0.81A 6b58A-3o3uN:
undetectable		 6b58A-3o3uN:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 11 PRO N 133
GLU N 130
PRO N 254
ALA N 163
PRO N 159
 None
 1.43A 6bm5A-3o3uN:
undetectable		 6bm5A-3o3uN:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU N 275
GLY N  24
VAL N  35
LEU N   7
ILE N   9
 None
 0.93A 6ecxA-3o3uN:
undetectable		 6ecxA-3o3uN:
19.69