SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		3 / 3 MET A  26
LEU A  29
SER A  30
 None
 0.63A 1ee2A-3o3wA:
undetectable		 1ee2A-3o3wA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		5 / 10 ILE A 120
GLY A 121
GLY A 122
ILE A 123
VAL A  51
 None
 0.98A 1sdtA-3o3wA:
undetectable		 1sdtA-3o3wA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		5 / 10 ASP A  53
ILE A  65
ILE A 123
GLY A 121
ILE A 120
 None
 1.06A 1sh9B-3o3wA:
undetectable		 1sh9B-3o3wA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		5 / 12 ASP A  34
GLY A 121
GLY A 122
ILE A 123
ILE A  91
 None
 1.01A 2o4kA-3o3wA:
undetectable		 2o4kA-3o3wA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		5 / 9 ASP A  34
ILE A 120
GLY A 122
ILE A 123
ILE A  91
 None
 1.23A 3ekyB-3o3wA:
undetectable		 3ekyB-3o3wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		4 / 4 ARG A 115
ASP A  53
GLY A 122
THR A  33
 None
 1.42A 3k4vB-3o3wA:
undetectable		 3k4vB-3o3wA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		5 / 12 ALA A 102
ALA A 110
PHE A 109
ILE A  50
ILE A  71
 None
 1.03A 4kjjA-3o3wA:
undetectable		 4kjjA-3o3wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		6 / 12 ILE A  76
ALA A 110
PHE A 109
ILE A  50
LEU A  84
ILE A  71
 None
 1.30A 4kjjA-3o3wA:
undetectable		 4kjjA-3o3wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		6 / 12 ILE A  76
ALA A 110
PHE A 109
ILE A  50
LEU A  84
ILE A  71
 None
 1.28A 4pssA-3o3wA:
undetectable		 4pssA-3o3wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3o3w BH2092 PROTEIN
(Bacillus
halodurans) 		3 / 3 LYS A  88
ILE A  50
ILE A  69
 None
 0.58A 4y0qA-3o3wA:
undetectable		 4y0qA-3o3wA:
21.30