SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3o3x GP41-5
(synthetic
construct) 		4 / 8 SER A  55
THR A  54
ASN A  51
LYS A  29
 None
 1.12A 1mxgA-3o3xA:
undetectable		 1mxgA-3o3xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3o3x GP41-5
(synthetic
construct) 		4 / 6 LEU A 101
GLN A  99
GLU A  96
ILE A  95
 None
 1.08A 2fcnA-3o3xA:
undetectable
2fcnB-3o3xA:
undetectable		 2fcnA-3o3xA:
18.52
2fcnB-3o3xA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3o3x GP41-5
(synthetic
construct) 		4 / 6 THR A 105
THR A  24
LEU A 183
THR A 186
 None
MPD  A 199 ( 4.6A)
None
None
 0.96A 3deuB-3o3xA:
undetectable		 3deuB-3o3xA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o3x GP41-5
(synthetic
construct) 		4 / 5 THR A  54
ASN A  51
TRP A  26
LEU A  23
 None
None
None
MPD  A 199 (-3.6A)
 1.21A 5vkqB-3o3xA:
3.6
5vkqC-3o3xA:
3.6		 5vkqB-3o3xA:
8.30
5vkqC-3o3xA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o3x GP41-5
(synthetic
construct) 		4 / 5 THR A  54
ASN A  51
TRP A  26
LEU A  23
 None
None
None
MPD  A 199 (-3.6A)
 1.22A 5vkqC-3o3xA:
3.6
5vkqD-3o3xA:
3.6		 5vkqC-3o3xA:
8.30
5vkqD-3o3xA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3o3x GP41-5
(synthetic
construct) 		4 / 8 GLY A  80
LEU A  76
GLY A  77
GLU A  72
 None
 0.88A 6mdqA-3o3xA:
undetectable		 6mdqA-3o3xA:
13.00