SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 PRO A 383
PHE A 258
PHE A 256
SER A 405
 None
 1.11A 1lqtA-3o44A:
undetectable		 1lqtA-3o44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 PRO A 383
PHE A 258
PHE A 256
SER A 405
 None
 1.10A 1lquA-3o44A:
undetectable		 1lquA-3o44A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 11 LEU A 626
GLY A 632
GLY A 631
ILE A 616
LEU A 639
 None
 1.14A 1p91A-3o44A:
undetectable		 1p91A-3o44A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 11 ALA A 678
VAL A 610
LEU A 608
LEU A 662
GLN A 672
 None
 1.14A 1rlbF-3o44A:
undetectable		 1rlbF-3o44A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		3 / 3 TYR A 194
ARG A 531
GLN A 526
 None
 0.92A 1tw4A-3o44A:
1.6		 1tw4A-3o44A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 10 GLU A 329
ASN A 343
LEU A 182
LEU A 211
TYR A 184
 None
 1.09A 2ha6B-3o44A:
undetectable		 2ha6B-3o44A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 SER A 505
ALA A 506
SER A 507
SER A 494
 None
 0.93A 2i91A-3o44A:
undetectable		 2i91A-3o44A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 SER A 505
ALA A 506
SER A 507
SER A 494
 None
 0.94A 2i91B-3o44A:
undetectable		 2i91B-3o44A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 ILE A 209
ILE A 402
ALA A 260
THR A 399
VAL A 448
 None
 1.08A 3a51E-3o44A:
undetectable		 3a51E-3o44A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 9 ALA A 583
LEU A 188
VAL A 186
SER A 398
PHE A 446
 None
 1.29A 3freX-3o44A:
undetectable		 3freX-3o44A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 9 TYR A 666
LEU A 662
VAL A 642
PHE A 713
VAL A 711
 None
 1.24A 3jwqA-3o44A:
undetectable		 3jwqA-3o44A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 10 LEU A 188
GLU A 189
THR A 396
TRP A 450
ASP A 451
 None
 1.18A 4driB-3o44A:
undetectable		 4driB-3o44A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 ILE A 616
PHE A 664
LEU A 699
LEU A 639
ILE A 645
 None
 1.10A 4km2B-3o44A:
undetectable		 4km2B-3o44A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 6 ILE A 402
PHE A 258
ILE A 180
ILE A 589
 None
 0.74A 4o8fB-3o44A:
undetectable		 4o8fB-3o44A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		4 / 8 LEU A 550
THR A 542
ARG A 535
LEU A 571
 None
 1.17A 4qknA-3o44A:
undetectable		 4qknA-3o44A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 VAL A 610
VAL A 711
LEU A 590
LEU A 690
LEU A 608
 None
 1.09A 5iktB-3o44A:
undetectable		 5iktB-3o44A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3o44 HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 VAL A 580
ASP A 579
ASP A 449
HIS A 452
PRO A 140
 None
 1.31A 5syfB-3o44A:
undetectable		 5syfB-3o44A:
21.75