SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 8 ILE A 150
ASN A 190
MET A 148
LEU A 169
 None
 0.93A 1dzmA-3o47A:
1.6		 1dzmA-3o47A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.40A 1fm6D-3o47A:
undetectable		 1fm6D-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.43A 1fm6X-3o47A:
undetectable		 1fm6X-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 237
ARG A 234
ILE A 285
LEU A 275
LEU A 251
 None
 1.08A 3k2hA-3o47A:
undetectable		 3k2hA-3o47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.84A 4ax8A-3o47A:
undetectable		 4ax8A-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.85A 4aztA-3o47A:
undetectable		 4aztA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.83A 4azvA-3o47A:
undetectable		 4azvA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 11 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.40A 4c5lA-3o47A:
4.3		 4c5lA-3o47A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 9 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.41A 4c5lB-3o47A:
undetectable		 4c5lB-3o47A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 10 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.45A 4c5lC-3o47A:
5.0		 4c5lC-3o47A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 10 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.41A 4c5lD-3o47A:
5.4		 4c5lD-3o47A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 7 ARG A 149
VAL A 198
TRP A 196
GLU A 243
 None
 1.39A 4jseA-3o47A:
undetectable
4jseB-3o47A:
undetectable		 4jseA-3o47A:
21.68
4jseB-3o47A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 7 GLU A 243
ARG A 149
VAL A 198
TRP A 196
 None
 1.43A 4jseA-3o47A:
undetectable
4jseB-3o47A:
undetectable		 4jseA-3o47A:
21.68
4jseB-3o47A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 275
SER A 224
VAL A 153
GLY A 154
 None
 1.01A 4klrB-3o47A:
2.9		 4klrB-3o47A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 ALA A 158
PHE A 254
LEU A 167
LEU A 300
ILE A 219
 GDP  A 502 (-3.9A)
None
None
None
None
 1.14A 4km2A-3o47A:
undetectable		 4km2A-3o47A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.94A 4uw0A-3o47A:
2.1		 4uw0A-3o47A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 6 ARG A 239
GLU A 243
PHE A 212
VAL A 153
 None
 1.36A 5h4dA-3o47A:
4.4		 5h4dA-3o47A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.49A 5ji0D-3o47A:
undetectable		 5ji0D-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 8 VAL A 221
GLN A 286
GLY A 299
LEU A 300
 None
 0.91A 5w3jB-3o47A:
4.7		 5w3jB-3o47A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		4 / 4 GLY A 154
LEU A 155
VAL A 198
GLU A 236
 None
 1.20A 5yw0A-3o47A:
undetectable		 5yw0A-3o47A:
21.29