SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 163
SER A 205
ASN A 192
THR A 232
 None
 1.15A 1h7xA-3o4fA:
3.5		 1h7xA-3o4fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 163
SER A 205
ASN A 192
THR A 232
 None
 1.16A 1h7xB-3o4fA:
3.3		 1h7xB-3o4fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 163
SER A 205
ASN A 192
THR A 232
 None
 1.15A 1h7xC-3o4fA:
3.0		 1h7xC-3o4fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 6 ILE A 163
SER A 205
ASN A 192
THR A 232
 None
 1.15A 1h7xD-3o4fA:
3.5		 1h7xD-3o4fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  87
GLU A 108
ASP A 140
GLY A 141
 None
 0.65A 1jg2A-3o4fA:
7.8		 1jg2A-3o4fA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A  85
GLY A  87
GLU A 108
ASP A 140
GLY A 141
 None
 0.69A 1jg3A-3o4fA:
7.6		 1jg3A-3o4fA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 11 GLY A  85
GLY A  87
GLU A 108
ASP A 140
GLY A 141
 None
 0.66A 1jg3B-3o4fA:
7.6		 1jg3B-3o4fA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  86
GLY A  87
GLU A 108
ASP A 139
 None
 1.12A 1qzzA-3o4fA:
12.7		 1qzzA-3o4fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  86
GLY A  87
GLU A 108
ASP A 140
 None
 0.83A 1qzzA-3o4fA:
12.7		 1qzzA-3o4fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  86
GLY A  87
GLU A 108
ASP A 139
 None
 1.05A 1xdsB-3o4fA:
12.0		 1xdsB-3o4fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A  85
GLY A  86
GLY A  87
GLU A 108
ASP A 140
 None
 0.80A 1xdsB-3o4fA:
12.0		 1xdsB-3o4fA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 10 ILE A  62
TYR A  63
GLU A   9
THR A  55
THR A  56
 None
 1.37A 2dttA-3o4fA:
1.1
2dttB-3o4fA:
0.6		 2dttA-3o4fA:
14.58
2dttB-3o4fA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 11 ILE A  62
MET A  66
ILE A 268
ALA A 272
ALA A 221
 None
 1.20A 2qhfA-3o4fA:
undetectable		 2qhfA-3o4fA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  54
HIS A  64
ASP A  88
GLN A 191
GLU A 201
 None
 1.39A 3b7pA-3o4fA:
34.4		 3b7pA-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		6 / 12 GLN A  54
TYR A  63
ASP A  88
ASP A 158
GLN A 191
TYR A 226
 None
 1.23A 3b7pA-3o4fA:
34.4		 3b7pA-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		6 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A  88
GLN A 191
TYR A 226
 None
 0.69A 3b7pA-3o4fA:
34.4		 3b7pA-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  54
ASP A  88
ASP A 158
GLN A 191
TYR A 226
 None
 1.20A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  54
HIS A  64
ASP A  88
GLN A 191
GLU A 201
 None
 1.31A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		6 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A  88
GLN A 191
TYR A 226
 None
 0.66A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A  88
TYR A 226
 None
 0.67A 3b7pC-3o4fA:
34.1		 3b7pC-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  84
ASP A 110
VAL A 113
ASP A 140
GLY A 141
 None
 0.94A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		6 / 12 ILE A  84
GLY A  85
ILE A 109
VAL A 114
ASP A 140
GLY A 141
 None
 1.34A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  84
ILE A 109
ASP A 110
ASP A 140
GLY A 141
 None
 1.05A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
ILE A 109
ASP A 140
GLY A 141
 None
 0.67A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
ILE A 109
GLY A 141
GLN A 191
 None
 0.92A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
VAL A 113
ASP A 140
GLY A 141
 None
 0.75A 3bwcA-3o4fA:
31.7		 3bwcA-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
ASP A  88
ILE A 109
GLY A 141
 None
 0.59A 3bwcB-3o4fA:
31.4		 3bwcB-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
ASP A  88
VAL A 113
GLY A 141
 None
 0.81A 3bwcB-3o4fA:
31.4		 3bwcB-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A  63
HIS A  64
ILE A  84
GLY A  85
GLN A 191
 None
 0.96A 3bwcB-3o4fA:
31.4		 3bwcB-3o4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		7 / 12 TYR A  63
ILE A  84
GLY A  85
ASP A  88
VAL A 113
GLY A 141
ASP A 158
 None
 1.25A 3bwcB-3o4fA:
31.4		 3bwcB-3o4fA:
40.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 11 VAL A  53
TYR A  63
ASP A  88
ASP A 158
GLN A 191
 None
 1.17A 3c6mA-3o4fA:
2.6		 3c6mA-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 11 VAL A  53
TYR A  63
ASP A  88
ASP A 158
TYR A 226
 None
 1.13A 3c6mA-3o4fA:
2.6		 3c6mA-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A  53
TYR A  63
ASP A  88
ASP A 158
GLN A 191
 None
 1.22A 3c6mC-3o4fA:
20.8		 3c6mC-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 10 VAL A  53
TYR A  63
ASP A  88
ASP A 158
TYR A 226
 None
 1.18A 3c6mC-3o4fA:
20.8		 3c6mC-3o4fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 8 TYR A 226
ASP A  88
ALA A  90
TYR A  63
 None
 1.11A 3rodA-3o4fA:
10.5		 3rodA-3o4fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 9 VAL A 189
TYR A 175
ILE A 187
ILE A 155
PHE A 174
 None
 1.34A 4afgA-3o4fA:
0.0
4afgB-3o4fA:
0.0		 4afgA-3o4fA:
18.39
4afgB-3o4fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 9 ILE A 187
ILE A 155
PHE A 174
VAL A 189
TYR A 175
 None
 1.13A 4afgA-3o4fA:
undetectable
4afgE-3o4fA:
undetectable		 4afgA-3o4fA:
18.39
4afgE-3o4fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 8 TYR A 175
CYH A 178
ILE A 156
ILE A  84
 None
 0.84A 4afgD-3o4fA:
undetectable
4afgE-3o4fA:
undetectable		 4afgD-3o4fA:
18.39
4afgE-3o4fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		4 / 8 VAL A 189
TYR A 175
ILE A 187
ILE A 155
 None
 0.74A 4afgD-3o4fA:
undetectable
4afgE-3o4fA:
undetectable		 4afgD-3o4fA:
18.39
4afgE-3o4fA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		3 / 3 THR A  96
SER A 128
ASP A  88
 None
 0.82A 5kvaA-3o4fA:
11.7		 5kvaA-3o4fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		3 / 3 THR A  96
SER A 128
ASP A  88
 None
 0.82A 5kvaB-3o4fA:
11.6		 5kvaB-3o4fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3o4f SPERMIDINE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  84
GLY A  85
GLY A  87
ALA A  90
ILE A 109
 None
 0.66A 6iftA-3o4fA:
9.5		 6iftA-3o4fA:
23.08