SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3o4o INTERLEUKIN-1
RECEPTOR TYPE 2
(Homo
sapiens) 		4 / 5 VAL C  65
GLY C  67
TRP C  74
TRP C  81
 None
 1.31A 1tkqB-3o4oC:
undetectable		 1tkqB-3o4oC:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		3 / 3 THR B  53
ASP B   6
SER B 103
 None
 0.86A 2nxeA-3o4oB:
undetectable		 2nxeA-3o4oB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 7 TYR B 101
ALA B  44
ALA B  41
LEU B  29
 NAG  B 340 (-4.0A)
None
None
None
 0.93A 2wx2A-3o4oB:
undetectable		 2wx2A-3o4oB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		5 / 12 HIS B  32
SER B 103
ARG B  13
PRO B  28
VAL B 105
 None
 1.39A 2xpvA-3o4oB:
undetectable		 2xpvA-3o4oB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 7 ASP B  58
ASP B  56
GLN B  55
GLU B  60
 None
None
NAG  B 338 (-4.3A)
None
 0.97A 3l2vA-3o4oB:
undetectable		 3l2vA-3o4oB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 8 TYR B 101
ALA B  44
ALA B  41
LEU B  29
 NAG  B 340 (-4.0A)
None
None
None
 0.98A 3l4dA-3o4oB:
undetectable		 3l4dA-3o4oB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 8 TYR B 101
ALA B  44
ALA B  41
LEU B  29
 NAG  B 340 (-4.0A)
None
None
None
 0.84A 3l4dD-3o4oB:
undetectable		 3l4dD-3o4oB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 8 ASP B  58
ASP B  56
GLN B  55
GLU B  60
 None
None
NAG  B 338 (-4.3A)
None
 1.03A 3oyaA-3o4oB:
undetectable		 3oyaA-3o4oB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3o4o INTERLEUKIN-1
RECEPTOR TYPE 2
(Homo
sapiens) 		5 / 12 TYR C 205
PRO C  32
ILE C 154
PHE C 145
ARG C  27
 None
 1.35A 4kovA-3o4oC:
undetectable		 4kovA-3o4oC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 4 LEU B  79
ARG B  82
ILE B  72
PHE B  81
 None
 1.33A 5kirB-3o4oB:
undetectable		 5kirB-3o4oB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		5 / 9 TYR B 101
ALA B  44
ALA B  41
LEU B  29
LEU B  48
 NAG  B 340 (-4.0A)
None
None
None
None
 1.10A 6ay6A-3o4oB:
undetectable		 6ay6A-3o4oB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		5 / 12 TYR B 101
ALA B  44
ALA B  41
LEU B  29
LEU B  48
 NAG  B 340 (-4.0A)
None
None
None
None
 1.03A 6aybA-3o4oB:
undetectable		 6aybA-3o4oB:
18.99