SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		4 / 7 LEU A 223
THR A 274
SER A 232
THR A 236
 None
 0.85A 1ictD-3o4rA:
undetectable		 1ictD-3o4rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 213
GLY A 271
GLY A 272
LEU A 242
SER A 276
 NAP  A 601 (-4.9A)
None
None
None
None
 1.04A 1xdsA-3o4rA:
8.2		 1xdsA-3o4rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 213
GLY A 271
GLY A 272
LEU A 242
SER A 276
 NAP  A 601 (-4.9A)
None
None
None
None
 1.04A 1xdsB-3o4rA:
8.1		 1xdsB-3o4rA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		3 / 3 THR A  38
SER A 115
PHE A 219
 None
None
NAP  A 601 (-4.1A)
 0.88A 3d4sA-3o4rA:
undetectable		 3d4sA-3o4rA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		3 / 3 SER A 218
ASP A  42
ASN A  68
 NAP  A 601 ( 4.4A)
NAP  A 601 (-3.9A)
NAP  A 601 (-3.8A)
 1.02A 3lsfB-3o4rA:
undetectable
3lsfE-3o4rA:
undetectable		 3lsfB-3o4rA:
22.34
3lsfE-3o4rA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		5 / 11 ILE A  48
ILE A  44
GLY A  43
VAL A 270
GLY A 243
 None
NAP  A 601 (-3.7A)
NAP  A 601 (-3.0A)
None
None
 1.03A 4ac9B-3o4rA:
6.5
4ac9C-3o4rA:
6.4		 4ac9B-3o4rA:
20.08
4ac9C-3o4rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		3 / 3 HIS A  89
SER A 115
ASN A 141
 NAP  A 601 ( 3.6A)
None
None
 0.91A 5cprB-3o4rA:
undetectable		 5cprB-3o4rA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		3 / 3 ASN A 120
ASP A  42
GLY A  43
 None
NAP  A 601 (-3.9A)
NAP  A 601 (-3.0A)
 0.60A 5fctB-3o4rA:
undetectable		 5fctB-3o4rA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens) 		3 / 3 LYS A 143
LEU A 147
ARG A  96
 None
 0.92A 5yw0A-3o4rA:
undetectable		 5yw0A-3o4rA:
20.00