SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 280
LEU A 283
ALA A 307
LEU A 311
 None
 0.88A 1pthA-3o4zA:
1.4		 1pthA-3o4zA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 280
LEU A 283
ALA A 307
LEU A 311
 None
 0.88A 1pthB-3o4zA:
1.5		 1pthB-3o4zA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 518
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.13A 1pxxA-3o4zA:
undetectable		 1pxxA-3o4zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 258
ILE A 228
ILE A 267
ALA A 183
 None
 0.71A 2nniA-3o4zA:
undetectable		 2nniA-3o4zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 538
ILE A 510
ALA A 506
GLU A 445
LEU A 490
 None
 1.22A 2v0mA-3o4zA:
undetectable		 2v0mA-3o4zA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
LEU A 150
GLY A 146
MET A 185
LEU A 171
 None
 1.44A 2w8yA-3o4zA:
undetectable		 2w8yA-3o4zA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 544
THR A 508
THR A 650
HIS A 646
 None
 1.39A 2zj0C-3o4zA:
undetectable		 2zj0C-3o4zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 230
VAL A 229
LEU A 234
SER A 260
 None
 1.20A 3b6rB-3o4zA:
undetectable		 3b6rB-3o4zA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 656
LEU A 685
ARG A 652
ILE A 634
GLY A 629
 None
 0.90A 3cv9A-3o4zA:
undetectable		 3cv9A-3o4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 5 PRO A  44
ILE A  89
PRO A  47
TYR A  46
 None
 1.39A 3d9lA-3o4zA:
3.1
3d9lY-3o4zA:
undetectable		 3d9lA-3o4zA:
12.48
3d9lY-3o4zA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 511
ASN A 519
SER A 545
PHE A 615
 None
 1.35A 3i9jB-3o4zA:
undetectable		 3i9jB-3o4zA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 10 SER A 528
LEU A 542
ILE A 522
SER A 485
GLY A 520
 None
 1.39A 3ik6B-3o4zA:
undetectable
3ik6E-3o4zA:
undetectable		 3ik6B-3o4zA:
18.42
3ik6E-3o4zA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.37A 3ln1A-3o4zA:
undetectable		 3ln1A-3o4zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.37A 3ln1B-3o4zA:
undetectable		 3ln1B-3o4zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.37A 3ln1C-3o4zA:
undetectable		 3ln1C-3o4zA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 518
ILE A 654
GLY A 543
ALA A 546
LEU A 549
 None
 1.14A 3n8yA-3o4zA:
undetectable		 3n8yA-3o4zA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 467
ILE A 466
ILE A 483
ALA A 480
LEU A 544
 None
 1.25A 3s79A-3o4zA:
undetectable		 3s79A-3o4zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  90
THR A  73
VAL A 134
ILE A  78
 None
 1.30A 4jx1F-3o4zA:
undetectable		 4jx1F-3o4zA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  49
ILE A  93
ILE A  71
PRO A  44
VAL A  45
 None
 0.93A 4q1yB-3o4zA:
undetectable		 4q1yB-3o4zA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 440
LEU A 507
ARG A 503
SER A 486
ILE A 510
 None
 1.29A 4ubsA-3o4zA:
2.2		 4ubsA-3o4zA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 480
LEU A 514
LEU A 511
ILE A 483
 None
 0.86A 4ubsA-3o4zA:
2.2		 4ubsA-3o4zA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.91A 5b1aA-3o4zA:
undetectable
5b1aJ-3o4zA:
undetectable		 5b1aA-3o4zA:
21.65
5b1aJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.96A 5b3sA-3o4zA:
undetectable
5b3sJ-3o4zA:
undetectable		 5b3sA-3o4zA:
21.65
5b3sJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 273
SER A 276
SER A 275
 None
 0.76A 5gsnA-3o4zA:
undetectable		 5gsnA-3o4zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 467
ILE A 466
ILE A 483
ALA A 480
LEU A 544
 None
 1.26A 5jkvA-3o4zA:
undetectable		 5jkvA-3o4zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 518
ALA A 627
GLY A 543
ALA A 546
SER A 545
LEU A 549
 None
 1.36A 5kirB-3o4zA:
undetectable		 5kirB-3o4zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 138
ILE A 139
TYR A 147
ILE A  98
 None
 1.43A 5odhG-3o4zA:
undetectable		 5odhG-3o4zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 9 TYR A 479
ILE A 483
ILE A 487
LEU A 490
 None
 0.66A 5vkqB-3o4zA:
3.4
5vkqC-3o4zA:
3.7		 5vkqB-3o4zA:
17.39
5vkqC-3o4zA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.95A 5zcoA-3o4zA:
2.4
5zcoJ-3o4zA:
undetectable		 5zcoA-3o4zA:
21.65
5zcoJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.91A 5zcpA-3o4zA:
2.2
5zcpJ-3o4zA:
undetectable		 5zcpA-3o4zA:
21.65
5zcpJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.92A 5zcqA-3o4zA:
2.4
5zcqJ-3o4zA:
undetectable		 5zcqA-3o4zA:
21.65
5zcqJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 250
VAL A 237
LEU A 241
LEU A 270
 None
 0.75A 6g9bA-3o4zA:
undetectable
6g9bB-3o4zA:
undetectable		 6g9bA-3o4zA:
10.02
6g9bB-3o4zA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2
(Saccharomyces
cerevisiae) 		4 / 5 THR A 508
THR A 650
HIS A 646
LEU A 538
 None
 1.20A 6gbnB-3o4zA:
undetectable		 6gbnB-3o4zA:
21.80