SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 8 SER A  88
SER A  89
SER A  64
ASN A  86
 NAG  A1001 (-3.4A)
NAG  A1002 ( 4.9A)
NAG  A1001 (-3.6A)
NAG  A1001 (-1.7A)
 1.07A 2cmlB-3o53A:
undetectable		 2cmlB-3o53A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 8 SER A  88
SER A  89
SER A  64
ASN A  86
 NAG  A1001 (-3.4A)
NAG  A1002 ( 4.9A)
NAG  A1001 (-3.6A)
NAG  A1001 (-1.7A)
 1.13A 2cmlC-3o53A:
undetectable		 2cmlC-3o53A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 7 TYR A 316
LEU A 250
LEU A 266
PHE A 280
 None
 1.29A 3nk2X-3o53A:
undetectable		 3nk2X-3o53A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 ASN A 283
GLY A 229
VAL A 286
PHE A 264
PHE A 257
 None
 1.21A 3r6wA-3o53A:
undetectable
3r6wB-3o53A:
undetectable		 3r6wA-3o53A:
20.57
3r6wB-3o53A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 VAL A 286
PHE A 264
PHE A 257
ASN A 283
GLY A 229
 None
 1.21A 3r6wA-3o53A:
undetectable
3r6wB-3o53A:
undetectable		 3r6wA-3o53A:
20.57
3r6wB-3o53A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 12 ALA A 184
LEU A 186
LEU A 196
LEU A 198
ASN A 182
 None
 0.80A 3r9cA-3o53A:
undetectable		 3r9cA-3o53A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
 None
 1.45A 3t3qA-3o53A:
undetectable		 3t3qA-3o53A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
 None
 1.48A 3t3qB-3o53A:
undetectable		 3t3qB-3o53A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
 None
 1.49A 3t3qC-3o53A:
undetectable		 3t3qC-3o53A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
 None
 1.46A 3t3qD-3o53A:
undetectable		 3t3qD-3o53A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 8 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
 None
 1.50A 3t3sD-3o53A:
undetectable		 3t3sD-3o53A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 10 LEU A 171
LEU A 193
ILE A 154
THR A 217
VAL A 181
 None
 1.35A 4mk4A-3o53A:
undetectable		 4mk4A-3o53A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 11 LEU A 117
LEU A  63
LEU A  82
LEU A 104
LEU A  61
 None
 1.01A 4zowA-3o53A:
undetectable		 4zowA-3o53A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 6 PHE A  79
VAL A  58
TYR A  34
ILE A  27
 None
 1.29A 5iwuA-3o53A:
undetectable		 5iwuA-3o53A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 7 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.44A 5mvsA-3o53A:
undetectable		 5mvsA-3o53A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		4 / 8 GLU A 252
LYS A 253
ALA A 254
ASP A 278
 None
 0.71A 5mvsB-3o53A:
undetectable		 5mvsB-3o53A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3o53 PROTEIN LRIM1
(Anopheles
gambiae) 		5 / 12 VAL A 114
LEU A 118
LEU A 126
ILE A 147
ALA A 128
 None
 1.30A 5xprA-3o53A:
undetectable		 5xprA-3o53A:
22.65