SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3o59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 ILE X 236
GLY X 238
GLU X 240
HIS X 183
GLU X 220
 None
 1.15A 1i7qA-3o59X:
undetectable		 1i7qA-3o59X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 10 ILE X 236
GLY X 238
GLU X 240
HIS X 183
GLU X 220
 None
 1.13A 1i7qC-3o59X:
undetectable		 1i7qC-3o59X:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 9 TYR X 101
ILE X  88
GLY X  90
ILE X  87
ALA X 105
 None
 1.19A 1mrgA-3o59X:
undetectable		 1mrgA-3o59X:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU X 263
VAL X 256
GLY X 255
ILE X 219
 None
 0.75A 1p2yA-3o59X:
undetectable		 1p2yA-3o59X:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 ILE X 125
VAL X 164
GLY X 165
LEU X 110
SER X 153
 None
 1.05A 2bxeA-3o59X:
2.1		 2bxeA-3o59X:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 ILE X 125
VAL X 164
GLY X 165
LEU X 110
SER X 153
 None
 1.06A 2bxeB-3o59X:
2.4		 2bxeB-3o59X:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 ILE X 236
GLU X 190
GLU X 220
GLY X 238
GLU X 240
 None
 1.22A 2fn1B-3o59X:
undetectable		 2fn1B-3o59X:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		6 / 12 LEU X 113
GLY X 116
ILE X  67
GLY X  59
ALA X  80
ILE X 112
 None
 1.49A 2rkfB-3o59X:
undetectable		 2rkfB-3o59X:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 LEU X 257
ARG X 215
MET X 214
VAL X 229
 None
 1.04A 2ygoA-3o59X:
undetectable		 2ygoA-3o59X:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 GLY X 271
GLU X 273
ASP X 166
ASP X 268
ILE X 267
 None
 1.39A 3id5B-3o59X:
undetectable		 3id5B-3o59X:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 GLY X 271
GLU X 273
ASP X 166
ASP X 268
ILE X 267
 None
 1.39A 3id5F-3o59X:
undetectable		 3id5F-3o59X:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 5 SER X 161
ARG X 245
GLY X 246
GLU X 190
 None
 1.34A 3k9fA-3o59X:
1.3
3k9fB-3o59X:
1.3
3k9fC-3o59X:
undetectable		 3k9fA-3o59X:
22.81
3k9fB-3o59X:
22.81
3k9fC-3o59X:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		6 / 12 ASP X  49
ALA X  51
VAL X  71
ILE X 112
GLY X 116
VAL X 117
 None
 1.30A 3nu5A-3o59X:
undetectable		 3nu5A-3o59X:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		6 / 12 ASP X  49
GLY X  52
ALA X  51
VAL X  71
ILE X 112
VAL X 117
 None
 1.26A 3nu5A-3o59X:
undetectable		 3nu5A-3o59X:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU X 250
TYR X 194
THR X 226
GLY X 148
 None
 0.85A 4eq4A-3o59X:
2.4		 4eq4A-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU X 250
TYR X 194
THR X 226
GLY X 148
 None
 0.86A 4eqlA-3o59X:
undetectable		 4eqlA-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU X 250
TYR X 194
THR X 226
GLY X 148
 None
 0.87A 4eqlB-3o59X:
2.3		 4eqlB-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 LEU X 250
TYR X 194
THR X 226
GLY X 148
 None
 0.91A 4l39A-3o59X:
2.1		 4l39A-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU X 250
TYR X 194
THR X 226
GLY X 148
 None
 0.90A 4l39B-3o59X:
2.2		 4l39B-3o59X:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		3 / 3 SER X 136
GLU X 220
GLU X 190
 None
 0.77A 4ymgB-3o59X:
undetectable		 4ymgB-3o59X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 ALA X 120
ARG X 245
GLY X 246
GLU X 190
 None
 0.89A 5bs8A-3o59X:
undetectable
5bs8C-3o59X:
undetectable
5bs8D-3o59X:
undetectable		 5bs8A-3o59X:
21.19
5bs8C-3o59X:
21.19
5bs8D-3o59X:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 ALA X 120
ARG X 245
GLY X 246
GLU X 190
 None
 0.94A 5btgA-3o59X:
undetectable
5btgB-3o59X:
undetectable
5btgC-3o59X:
undetectable		 5btgA-3o59X:
21.19
5btgB-3o59X:
24.61
5btgC-3o59X:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 LEU X 263
ILE X 221
TYR X 146
ALA X 120
ILE X 150
 None
 0.90A 5gpgA-3o59X:
undetectable		 5gpgA-3o59X:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 10 TYR X 145
ILE X 219
TYR X 146
THR X 222
ILE X 221
 None
 0.98A 5mzrA-3o59X:
undetectable		 5mzrA-3o59X:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		5 / 10 TYR X 145
ILE X 219
TYR X 146
THR X 222
ILE X 221
 None
 0.98A 5mzrC-3o59X:
undetectable		 5mzrC-3o59X:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3o59 DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
horikoshii) 		3 / 3 GLU X 185
HIS X 233
ARG X 186
 None
 0.98A 5uunA-3o59X:
undetectable		 5uunA-3o59X:
25.15